A single-cell atlas of the bobtail squid visual and nervous system highlights molecular principles of convergent evolution [0.03%]
一只皮虎squid的视觉和神经系统单细胞图谱揭示了收敛进化的基本分子原理
Daria Gavriouchkina,Yongkai Tan,Elise Parey et al.
Daria Gavriouchkina et al.
The cephalopod and vertebrate visual systems are a textbook example of convergent evolution with unknown molecular underpinnings. Here we characterize 98,537 single-cell transcriptomes in the bobtail squid Euprymna berryi to understand how ...
Mapping the immune cells of the testis: Key insights into sexual maturation [0.03%]
绘制睾丸免疫细胞图谱：青春期性成熟的奥秘
Xiaoyu Wu,Chenzhao Feng,Zunpan Fan et al.
Xiaoyu Wu et al.
Objective: To systematically delineate the immune cell atlas and developmental trajectory of testicular leukocytes before and after sexual maturation.
Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders [0.03%]
烟雾病中循环T细胞图谱在脑血管疾病免疫病理发生中的启示
Chenglong Liu,Junsheng Li,Siqi Mou et al.
Chenglong Liu et al.
Background: Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis or occlusion of the intracranial arteries, accompanied by the formation of fragile collateral vessels, ultimat...
Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro [0.03%]
人呼吸道单细胞分析鉴定出具有体外细胞因子依赖性分化偏向的纤毛-离子细胞祖细胞
Viral S Shah,Avinash Waghray,Brian Lin et al.
Viral S Shah et al.
Here, using a lung cell atlas of 311,748 single cell RNA-Seq profiles, we identify 687 ionocytes (0.45%). In contrast to prior reports claiming a lack of ionocytes in the small airways, we demonstrate that ionocytes are present in small and large airways in similar proportions.
Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair [0.03%]
单细胞转录组揭示动脉修复中CXCL2介导的平滑肌细胞增殖现象
Xingxiao Huang,Yan Ping,Qiuli Sun et al.
Xingxiao Huang et al.
Conclusions: This study provides a comprehensive cell atlas of the injured artery, offering valuable insights into the complex cellular interactions, signaling pathways and immune responses involved in orchestrating vascular repair.
Hematopoietic Single Cell Atlas Reveals a Diverse Repertoire of Lymphoid Cells in Larval Zebrafish [0.03%]
造血单细胞图谱揭示了幼鱼斑马鱼淋巴样细胞的多样谱系
Anastasia Nizhnik,Bianca A Ulloa,Kevyn Jackson et al.
Anastasia Nizhnik et al.
During embryogenesis, hematopoietic stem cells (HSC) and HSC-independent progenitor cells form concurrently and produce overlapping and distinct immune cell types. The full repertoire of immune cells generated during development and their o...
Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles [0.03%]
犬自然杀伤细胞单细胞图谱鉴定出不同循环和驻留组织基因型
Aryana M Razmara,Marshall Lammers,Sean J Judge et al.
Aryana M Razmara et al.
Introduction: Natural killer (NK) cells in mice and humans are key effectors of the innate immune system with complex immunoregulatory functions, and diverse subsets have been identified with distinct characteristics and ...
Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures [0.03%]
小鼠内耳衰老的单细胞核解析揭示了细胞异质性和毛细胞亚型特异性衰老标志
Mingyu Xia,Feng Zhang,Jiaoyao Ma et al.
Mingyu Xia et al.
Here, we constructed an aging-associated cell atlas of cochlear and utricular tissues in C57BL/6J mice through single-nucleus RNA sequencing, revealing transcriptionally distinct hair cell subtypes and spatially restricted molecular markers that delineate specific cellular populations.
SCIG: Machine learning uncovers cell identity genes in single cells by genetic sequence codes [0.03%]
基于基因序列代码的机器学习揭示单细胞身份基因
Kulandaisamy Arulsamy,Bo Xia,Yang Yu et al.
Kulandaisamy Arulsamy et al.
Applying SCIG to the human endothelial cell atlas revealed that the tissue microenvironment is a critical supplement to master TFs for cell identity refinement.
Single-cell atlas of endothelial cells in atherosclerosis: identifying C1 CXCL12+ ECs as key proliferative drivers for immunological precision therapeutics in atherosclerosis [0.03%]
动脉粥样硬化内皮细胞单细胞图谱：识别C1 CXCL12+ EC作为动脉粥样硬化免疫精确诊疗的关键增殖驱动因素
Zhenzhen Zhao,Yujiang Dong,Zhijie Zhao et al.
Zhenzhen Zhao et al.
Background: Atherosclerosis (AS) is a chronic inflammatory disease characterized by endothelial dysfunction, monocyte infiltration, smooth muscle proliferation, and extracellular matrix accumulation. Endothelial cell (EC)...
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