Targeted inhibition of Ninjurin2 promotes chemosensitivity in chemoresistant gastric cancer by suppressing cancer-initiating cells [0.03%]
Ninjurin2靶向抑制通过抑制癌症起始细胞促进化学抗性胃癌的化疗敏感性
Hyo Shik Shin,Jae-Il Choi,Hye Won Chung et al.
Hyo Shik Shin et al.
Background: The combination of epirubicin, cisplatin, and 5-fluorouracil (ECF) is widely used for gastric cancer treatment. However, cancer cells can acquire chemoresistance over multiple treatment cycles, leading to recu...
The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses [0.03%]
结肠癌始发细胞的整合基因组和功能性免疫学分析以调节干性特性和对免疫反应的易感性
Issam Tout,Salim Bougarn,Mohammed Toufiq et al.
Issam Tout et al.
Background: Colorectal cancer (CRC) initiating cells (CICs) possess self-renewal capabilities and are pivotal in tumor recurrence and resistance to conventional therapies, including immunotherapy. The mechanisms underlyin...
SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis [0.03%]
SNORD88B介导的WRN核仁转运驱动肝癌起始细胞自我更新和肝细胞癌发生发展
Yang Gu,Zhibin Yi,Ziheng Zhou et al.
Yang Gu et al.
Whether small nucleolar RNAs (snoRNAs) are involved in the regulation of liver cancer stem cells (CSCs) self-renewal and serve as therapeutic targets remains largely unclear. Here we show that a functional snoRNA (SNORD88B) is robustly expr...
Aldehyde Dehydrogenese-1 High Cancer Stem-like Cells/Cancer-initiating Cells Escape from Cytotoxic T Lymphocytes due to Lower Expression of Human Leukocyte Antigen Class 1 [0.03%]
醛脱氢酶高表达的肺癌干细胞样细胞/肿瘤起始细胞因人类白细胞抗原Ⅰ类分子较低表达而逃逸细胞毒性T淋巴细胞的作用
Tomohide Shirosaki,Noriko Kawai,Yuma Ebihara et al.
Tomohide Shirosaki et al.
Background/aim: Human gastric cancer stem-like cells (CSCs)/cancer-initiating cells can be identified as aldehyde dehydrogenase-high (ALDHhigh) cells. Cancer immunotherapy employing immune checkpoint blockade has been app...
[Retracted] Human HLA‑F adjacent transcript 10 promotes the formation of cancer initiating cells and cisplatin resistance in bladder cancer [0.03%]
人类HLA-F邻近转录本10促进膀胱癌中癌症起始细胞的形成和顺铂抗性
Chen Li,Zhenfan Wang,Ninghan Feng et al.
Chen Li et al.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the cellular morphological data in Fig. 1C, the immunofluorescence data shown in Fig. 1E, and certain of the scratch‑wound assay dat...
Retraction of Publication
Molecular medicine reports. 2024 Apr;29(4):63. DOI:10.3892/mmr.2024.13187 2024
A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer [0.03%]
靶向端粒的药物耗竭小细胞肺癌中的癌症起始细胞并促进抗肿瘤免疫作用
Buse Eglenen-Polat,Ryan R Kowash,Hai-Cheng Huang et al.
Buse Eglenen-Polat et al.
There are few effective treatments for small cell lung cancer (SCLC) underscoring the need for innovative therapeutic approaches. This study focuses on exploiting telomerase, a critical SCLC dependency as a therapeutic target. A prominent c...
Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling [0.03%]
来自COPD患者的细胞外囊泡通过HIF-1α运输调节癌症起始细胞表型
Ilaria Petraroia,Patrizia Ghidotti,Giulia Bertolini et al.
Ilaria Petraroia et al.
Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding microenvironmental cells also modulating the release and carg...
[Retracted] miR‑206 inhibits cancer initiating cells by targeting EHF in gastric cancer [0.03%]
[撤回]:miR-206通过靶向EHF抑制胃癌干细胞
Yan-Cui Gong,Guo-Liang Ren,Bo Liu et al.
Yan-Cui Gong et al.
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the colony formation assay data shown in Figs. 2, 4 and 8 were strikingly similar to data that had already appeared in another articl...
Retraction of Publication
Oncology reports. 2023 Nov;50(5):197. DOI:10.3892/or.2023.8634 2023
Triple-negative mouse breast cancer initiating cells show high expression of beta1 integrin and increased malignant features [0.03%]
三阴性小鼠乳腺癌干细胞β1整合素高表达且恶性表型更为明显
Jing Fu,Shengkun Peng
Jing Fu
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that exhibits aggressive tumor phenotypes, including rapid metastasis and tumor recurrence. Integrins belong to the family of transmembrane glycoproteins involved in regulat...
Chemotherapy induces feedback up-regulation of CD44v6 in colorectal cancer initiating cells through β-catenin/MDR1 signaling to sustain chemoresistance [0.03%]
化疗通过β-连环蛋白/MDR1信号在结肠直肠癌起始细胞中诱导CD44v6的反馈上调以维持耐药性
Shibnath Ghatak,Vincent C Hascall,Nikos Karamanos et al.
Shibnath Ghatak et al.
Chemoresistance in colorectal cancer initiating cells (CICs) involves the sustained activation of multiple drug resistance (MDR) and WNT/β-catenin signaling pathways, as well as of alternatively spliced-isoforms of CD44 containing variable exon-6 (CD44v6)....Keywords: CD44v6; MDR1; WNT3A; cancer initiating cells (CICs); colon rectal cancer (CRC). Copyright © 2022 Ghatak, Hascall, Karamanos, Markwald and Misra.
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