Molecular basis for the calcium-dependent activation of the ribonuclease EndoU [0.03%]
钙依赖的核糖核酸酶EndoU活化的分子机制
Florian Malard,Kristen Dias,Margaux Baudy et al.
Florian Malard et al.
In this study, we use biophysical and computational techniques along with in vitro assays to investigate the calcium-dependent activation of human EndoU.
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss [0.03%]
帕金森病突变体Miro1导致线粒体功能障碍和多巴胺神经元丢失
Axel Chemla,Giuseppe Arena,Ginevra Sacripanti et al.
Axel Chemla et al.
This resulted in the calcium-dependent activation of calpain proteases and the subsequent cleavage of α-synuclein.
From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics [0.03%]
从房室小型钙激活钾通道到新的抗心律失常药
Arnela Saljic,Jordi Heijman,Dobromir Dobrev
Arnela Saljic
Here, the molecular composition of smallconductance calcium-activated potassium channels and their complex regulation in AF as the basis for understanding the distinct mechanism of action of pore-blockers (apamin, UCL1684, ICAGEN) and modulators of calcium-dependent activation (NS8593, AP14145, AP30663
Estrogens increase cancer cell efferocytosis to establish an immunosuppressive tumor microenvironment [0.03%]
雌激素通过增加癌细胞摄取凋亡细胞来建立免疫抑制性肿瘤微环境
Binita Chakraborty,Prabuddha Chakraborty,Michael C Brown et al.
Binita Chakraborty et al.
Mechanistically, E2 facilitates calcium-dependent activation of the transcription factor NFATC1, which in turn induces CX3CR1 expression. This drives macrophage polarization towards an immune-suppressive state, increasing the ability of TAMs to engulf pro-inflammatory apoptotic cancer cells.
A Novel Single-Color FRET Sensor for Rho-Kinase Reveals Calcium-Dependent Activation of RhoA and ROCK [0.03%]
一种新型的单色FRET传感器可检测Rho激酶并揭示钙依赖性激活的RhoA和ROCK
Allison E Mancini,Megan A Rizzo
Allison E Mancini
Blocking calmodulin or CaMKII prevented calcium-dependent activation of ROCK.
Empagliflozin Prevent High-Glucose Stimulation Inducing Apoptosis and Mitochondria Fragmentation in H9C2 Cells through the Calcium-Dependent Activation Extracellular Signal-Regulated Kinase 1/2 Pathway [0.03%]
恩格列净通过钙依赖激活细胞外信号调节激酶1/2通路预防高糖刺激诱导的H9C2细胞凋亡及线粒体碎裂
Yung-Lung Chen,Hui-Ting Wang,Wen-Chin Lee et al.
Yung-Lung Chen et al.
Our study shows that empagliflozin could reverse the HG condition, causing a calcium-dependent activation of the ERK 1/2 pathway, which caused mitochondria fragmentation in H9C2 cells.
Elizabeth L McDuffie,Reynold A Panettieri Jr,Charles P Scott
Elizabeth L McDuffie
Airway shortening occurs through calcium-dependent activation of myosin light chain kinase, and RhoA-dependent calcium sensitization, which inhibits myosin light chain phosphatase. The mechanism through which pro-contractile stimuli activate calcium sensitization is poorly understood.
Molecular Basis for the Calcium-Dependent Activation of the Ribonuclease EndoU [0.03%]
内切酶EndoU钙离子激活的分子机制研究
Florian Malard,Kristen Dias,Margaux Baudy et al.
Florian Malard et al.
In this study, we used biophysical and computational techniques along with in vitro assays to investigate the calcium-dependent activation of human EndoU.
A novel single-color FRET biosensor for Rho-kinase activity reveals calcium-dependent activation of RhoA and ROCK [0.03%]
一种新型的单色FRET生物传感器可检测Rho激酶活性并揭示钙依赖性激活的RhoA和ROCK
Allison E Mancini,Megan A Rizzo
Allison E Mancini
Blocking calmodulin or CaMKII prevented calcium-dependent activation of ROCK. These results indicate that ROCK activity is increased by calcium in fibroblasts and that this activation occurs downstream of CaM/CaMKII.
Characterization of PDGF-Induced Subcellular Calcium Regulation through Calcium Channels in Airway Smooth Muscle Cells by FRET Biosensors [0.03%]
荧光共振能量转移生物传感器测定气道平滑肌细胞中PDGF通过钙通道诱导的亚细胞钙调节特征
Mingxing Ouyang,Binqian Zhou,Chunmei Li et al.
Mingxing Ouyang et al.
Interestingly, the removal of the extracellular calcium influx led to inhibited ER calcium release, likely through inhibitory effects on the calcium-dependent activation of the ER ryanodine receptor.
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