Pallav Gandhi,Shital Panchal Pallav Gandhi

Although bisabolol and bromelain exhibited some efficacy, their effects were comparatively lower.

Zan Hu,Yu Wang,Dawei Yu et al. Zan Hu et al.

Under the optimal extraction conditions, with a neutral protease to bromelain ratio of 75:25, enzyme concentration of 5 %, and pH of 6, the HAAs concentration reached 127.63 ng/g.

Matthew B Bratton,Jaclyn P Murphy,Jessica C Rivera Matthew B Bratton

As a result, researchers hypothesized that bromelain could be used to debride contaminated orthopedic implants. Methods: In this study, cortical bone screws were incubated in methicillin-resistant Staphylococcus aureus inoculated broth....Treatment groups were exposed to low-dose bromelain solution, high-dose bromelain solution, or bromelain powder with or without manual scrubbing of the implant. The screws were then stained with crystal violet dye and analyzed using optical density (OD)....The average OD of the low-dose bromelain solution group (0.104 ± 0.047) was no different compared with the control group (p = 0.345)....The average ODs of the low-dose + scrub bromelain solution (0.068 ± 0.020) and high-dose + scrub solution (0.045 ± 0.014) were significantly different from their respective control group (p = 0.012; p = 0.001)....Discussion: On the basis of these outcomes, bromelain is a promising alternative for the debridement of biofilm-contaminated orthopedic implants.

Suganya Bharathi Balakrishnan,Lilian Ibrahim,Esakkimuthu Shanmugasundaram et al. Suganya Bharathi Balakrishnan et al.

In this article, we disclose the encapsulation of bromelain in a poly-(vinyl alcohol) (PVA)/hydroxyethyl cellulose (HEC) matrix to create a new type of nanofibrous scaffold....After examining the physicochemical properties of the nanofibrous scaffolds, it was discovered that bromelain was successfully incorporated into PVA/HEC nanofibers, providing a significant morphological structure to the scaffolds....The in vitro release study indicated that the loaded bromelain exhibited a sustained and controlled release behavior from the PVA/HEC nanofibrous scaffolds, thereby effectively inhibiting the growth of HeLa cells, as evidenced by microscopic observations....It should be emphasized that the PVA/HEC nanofibrous scaffold containing bromelain may have a promising application for cancer therapy. © 2025 The Authors. Published by American Chemical Society.

Enzo Maria Vingolo,Mattia Calabro,Simona Mascolo et al. Enzo Maria Vingolo et al.

Objectives: This study aimed to assess the impact of an oral formulation combining bromelain (250 mg) derived from Ananas comosus (L.) Merr....Group A (20 eyes) was administered one tablet containing 250 mg of bromelain and 250 mg of diosmin mcgSMIN Plus twice daily for a period of two months. Group B (20 eyes) was monitored without drug administration until the next IVT. After two months and IVT administration, the groups were switched....Conclusions: Orally administered combination of bromelain 250 mg and 250 mg diosmin mcgSMIN Plus has positive impact on central retinal thickness in patients treated for cystoid center-involving diabetic macular edema (DME) with anti-VEGF intravitreal maintenance therapy.

Lucia Recinella,Morena Pinti,Silvia Di Lodovico et al. Lucia Recinella et al.

Biofilm plays a crucial role in the pathogenesis and chronicity of urinary tract infections (UTIs). The present work aimed to evaluate the anti-biofilm effects of Formulation (DIF17BRO® plus NAC) in combination with ciprofloxacin (CPX) on ...

Irislene Costa Pereira,Raquel Barros Passos,Camila de Meneses Caetano Viana et al. Irislene Costa Pereira et al.

Systemic therapies for the treatment of cancer collaborate to reduce cancer progression and have been used for decades. However, despite the clinical benefits, its long-term use is associated with toxicity, promoting important side effects ...

Cyaandi R Dove,Robert J Snyder,Keren David Zarbiv et al. Cyaandi R Dove et al.

Background: A randomized controlled trial reported that bromelain-based enzymatic debridement (BBD) more effectively debrided and granulated venous leg ulcers (VLUs) compared with placebo (gel vehicle, hydrogel) and nonsu...

Shupeng Chen,Hongyu Pan,Pengtao Huan et al. Shupeng Chen et al.

Walnut protein was hydrolyzed by different enzymes, and bromelain protein hydrolysate (W-Bromelain) showed the highest dipeptidyl peptidase-IV (DPP-IV) inhibitory activity. W-Bromelain was fractionated, and three novel tetrapeptides (LPQF, LPSF, and VPFP) were identified.

Bhupesh Dewan,Siddheshwar Shinde,Nisha Motwani Bhupesh Dewan

This study was designed to assess the safety and effectiveness of treatment with Tibrolin® (a fixed-dose combination of trypsin 48 mg, bromelain 90 mg, and rutoside 100 mg tablet) in improving wound healing and alleviating acute pain in patients following uncontaminated surgeries.