Sabrina A Primus,Felix Hoffstaedter,Federico Raimondo et al.
Sabrina A Primus et al.
We examined LBS genetics of 22 subcortical brain structures and cerebellum in 19,862 healthy White-British UK Biobank participants by multivariate genome-wide association study on the first 49 eigenvalues each....Significant correlations between LBS of several brain structures and the polygenic risks of hypertension, ischemic stroke, and schizophrenia evince brain shapes as early biomarkers.
Histone Acetylation Modifications and HDACs are Associated with Resilience or Susceptibility to Stress in a Rat Model of Major Depressive Disorder [0.03%]
组蛋白乙酰化修饰及HDACs与抑郁症易感性的表观遗传关联研究
Lucas Santos,Luana Possa,Nicole Fröhlich et al.
Lucas Santos et al.
Here, for the first time it is demonstrated that resilient and susceptible to CUMS animals present different patterns of histone acetylation and histone deacetylases regulation in distinct brain structures animals.
Human immunodeficiency virus accelerates brain aging and disrupts the trajectory of glymphatic clearance in aging brain [0.03%]
人类免疫缺陷病毒加速脑部衰老并破坏老化脑部淋巴循环清除路径的轨迹
Benedictor Alexander Nguchu,Jing Zhao,Yu Lu et al.
Benedictor Alexander Nguchu et al.
Results: Our results showed that subjects with HIV had increased brain-PAD in several brain structures compared to those who were HIV-negative, suggesting underlying neuropathology associated with HIV....The brain structures demonstrating accelerated aging (increased brain-PAD) include the middle frontal gyrus, pre-and post-central gyri, supramarginal gyrus, precuneus, cuneus, parietal lobule and operculum, and superior and middle occipital gyri of the left hemisphere.
Distinguishing Lifelong Individual Differences from Divergent Aging Trajectories of Adult Brain Volumes [0.03%]
终生个体差异与成人脑体积发散衰老轨迹的区别
Edvard O S Grødem,Didac Vidal Pineiro,Øystein Sørensen et al.
Edvard O S Grødem et al.
Differences in the volumes of brain structures between individuals are often linked to various conditions, including Alzheimer's disease, schizophrenia, and overall brain health....In this study, we analyze the aging dynamics of the volume of six brain structures based on MRI scans from a large cross-cohort longitudinal sample of cognitively healthy adults (n = 8,311 with 18,520 MRIs, ages from 18 to 97 years).
Regional Brain Volume and Cortical Thickness Mediate Age-Related Differences in Eye Movement Control [0.03%]
年龄相关的眼球运动控制差异的脑网络基础：区域性脑结构变化的影响
Rika Etteldorf,Annabell Coors,Santiago Estrada et al.
Rika Etteldorf et al.
Mediation analyses suggested that age-related differences in brain structures explain up to 18% of age-related differences in oculomotor performance.
Assessing the role of volumetric brain information in multiple sclerosis progression [0.03%]
评估脑体积信息在多发性硬化症进展中的作用
Andy A Shen,Aidan McLoughlin,Zoe Vernon et al.
Andy A Shen et al.
Understanding multiple sclerosis progression and identifying the implicated brain structures is crucial for personalized treatment decisions.
A systematic review: Brain age gap as a promising early diagnostic biomarker for Alzheimer's disease [0.03%]
系统综述：脑部年龄差距有望成为阿尔茨海默病早期诊断的生物标志物
Shuting Liu,Longchun Xu,Guihua Xu et al.
Shuting Liu et al.
While the brain structures of healthy aging individuals change gradually, the aging trajectories in AD patients deviate significantly. Recent advancements in deep learning have enabled the detection of subtle changes in brain structures using neuroimaging data.
Putative Mechanisms of Electroconvulsive Therapy in Treatment-Resistant Schizophrenia Examined Using Magnetic Resonance Imaging [0.03%]
利用磁共振成像研究难治性精神分裂症电休克治疗的潜在机制
Neelabja Roy,Dhruva Ithal,Urvakhsh Meherwan Mehta et al.
Neelabja Roy et al.
These findings suggest that ECT may help people with treatment-resistant schizophrenia by changing specific brain structures and connections, particularly the amygdala and cerebellum. © 2025 The Authors.
Lead neurotoxicity in experimental models: A systematic review on effects on the cerebrum, cerebellum, and hippocampus [0.03%]
铅神经毒性的实验模型系统性回顾：对大脑皮层、小脑和海马区的影响
Fredrick Ohiomokhai Tobalu,Adaze Bijou Enogieru
Fredrick Ohiomokhai Tobalu
These findings provide an updated compilation of lead toxicity and its mechanisms of action on different brain structures in experimental models.
Differential impact of microcystins MC-LR and [D-Leu1]MC-LR in different areas of the rat brain after chronic exposure: oxidative stress and antioxidant responses [0.03%]
慢性暴露后微囊藻毒素MC-LR和[D-Leu1]MC-LR对大鼠脑不同区域的差异化影响：氧化应激与抗氧化响应
Hernando Marcelo,Cogo Pagella Joaquín,de la Rosa Florencia et al.
Hernando Marcelo et al.
The aim of this study was to determine the impact of [D-Leu1]MC-LR and MC-LR administration on different brain structures in rats and the resulting modifications in oxidative stress.
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