Extracellular Vesicle-Packaged MIR4435-2HG Facilitates Cigarette Smoke-Induced Bladder Cancer Progression through Enolase 1-Dependent Glycolytic Reprogramming [0.03%]
细胞外囊泡包装的MIR4435-2HG通过烯醇化酶1依赖性糖酵解重编程促进香烟烟雾诱导的膀胱癌进展
Rui Zheng,Yanping Xiao,Jialei Yang et al.
Rui Zheng et al.
Epidemiological studies have reported that cigarette smoking promotes bladder cancer progression, but the corresponding biological mechanisms must be elucidated.
Association between low handgrip strength and the increased risk of age-related macular degeneration: results from UK biobank cohort study [0.03%]
较低的手握力与年龄相关性黄斑变性的发病风险之间的关联：来自英国生物样本库队列研究的结果
Shuoyang Wang,Yu Hong,Yanlin Qu et al.
Shuoyang Wang et al.
Specific inflammatory and erythrocyte-related biomarkers partially (37.5%) mediated the incidence of age-related macular degeneration as substantial biological mechanisms following handgrip strength decrease.
A comprehensive review of sex differences in the clinical outcomes to immunotherapy on solid tumors [0.03%]
免疫治疗对实体瘤临床疗效的性别差异全面回顾
Juan Carlos Redondo-González,Luis Posado-Domínguez,Laura Corvo-Félix et al.
Juan Carlos Redondo-González et al.
The aim of this comprehensive review is to evaluate the available evidence and the biological mechanisms that could explain these differences. Some recent meta-analyses have suggested a greater overall survival benefit for males.
Sanctuary sites and extramedullary relapses in the chemo-free world: insights from immunotherapies in B-ALL [0.03%]
无化疗时代的避难 sanctuary 症和中枢神经系统以外的复发：B 细胞急淋免疫治疗带来的启示
Ryan D Cassaday
Ryan D Cassaday
The biological mechanisms underpinning this process are not clear, but they are presumed to involve a multifactorial interplay between tumor cells and the microenvironment of the tissue in which they develop (eg, lymph nodes, thymus, leptomeninges).
Mechanisms of root exudates and soil microbial responses to nitrogen reduction and companion cropping for tomato yield increase and quality improvement [0.03%]
减氮与间作下番茄根系分泌物及土壤微生物对产量和品质改善的影响机制
Deyang Liu,Xingjia He,Yingxue Liu et al.
Deyang Liu et al.
In order to explore the biological mechanisms of nitrogen reduction and companion planting patterns on tomato yield and quality, this study conducted a two-year pot experiment under different nitrogen application levels and planting patterns, multisystem analysis of tomato rhizosphere soil microbial
Metabolic characteristics related to potentially toxic elements in the blood of young adults in China: a cross-sectional study [0.03%]
中国年轻人血液中潜在有毒元素的相关代谢特征：一项横断面研究
Lei Zhang,Wen Xu,Mingyu Feng et al.
Lei Zhang et al.
Epidemiological evidence links essential and potentially toxic metals exposure to impaired lung function, but underlying biological mechanisms remain unclear.
Explainable AI in healthcare: to explain, to predict, or to describe? [0.03%]
医疗保健中的可解释性AI：为了可解释性、预测还是描述？
Alex Carriero,Anne de Hond,Bram Cappers et al.
Alex Carriero et al.
Using the Describe-Predict-Explain framework, we argue that Explainable AI methods are good descriptive tools, as they may help to describe how a model works but are limited in their ability to explain why a model works in terms of true underlying biological mechanisms and cause-and-effect relations.
Night shift work and breast cancer: from etiopathology to precision risk analysis [0.03%]
从病因病理到精准风险评估：夜班工作与乳腺癌的关系
Silvia Vivarelli,Tania Formica,Ylenia Puliatti et al.
Silvia Vivarelli et al.
This review explores three key areas: (1) the biological mechanisms potentially linking NSW to BC, including melatonin suppression, oxidative stress, immune dysregulation, chronic inflammation, clock gene alterations, epigenetic modifications, telomere shortening, estrogen signaling disruption, vitamin
Chen-Lu Chang,Jia-Wen Li,Zheng-Kai Shen et al.
Chen-Lu Chang et al.
As the prevalence of muscle-related diseases rises, it becomes increasingly important to understand the complex biological mechanisms that underlie these conditions to develop effective, targeted therapeutic strategies.
Retinal Vulnerability to Light Pollution in Vitiligo: A Narrative Review of the Role of Melanin Loss in Ocular Phototoxicity [0.03%]
白癜风视网膜光污染脆弱性：黑色素丢失在眼光毒性作用中的角色的叙述性综述
Maria Ana Contin,Manuel G Bruera,Mohd Nasir Mat Nor et al.
Maria Ana Contin et al.
Key messages: We discuss the biological mechanisms of retinal vulnerability in the absence of melanin and the implications for understanding sub-clinical retinal changes in individuals with vitiligo.
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