GALNT14 deficiency: connecting multiple links in the IgA nephropathy pathogenetic chain [0.03%]
岩藻糖转移酶 GALNT14 缺陷与 IgA 肾病发病机制链的多个环节相关
John Pell,Madhav C Menon
John Pell
The authors then performed a classical bedside-to-bench investigation using a Galnt14-/- mouse model and connected loss of GalNAc-T14 to excess IgA production, impaired B lymphocyte homing, and defective intestinal mucus production.
The Microbiome in Asthma Heterogeneity: The Role of Multi-Omic Investigations [0.03%]
哮喘异质性中的微生物组：多组学研究的作用
Yvonne J Huang
Yvonne J Huang
This review will highlight recent evidence in this area, focusing on bedside-to-bench investigations that have leveraged omic technologies to uncover microbiome links to asthma outcomes and immunobiology. Studies centered on the respiratory system and the use of multi-omics are noted in particular.
Preserving potential: Surgeons as key partners in establishing a living sarcoma biobank for translational research purposes [0.03%]
保护潜在价值：外科医生在建立活体肉瘤生物库以促进转化研究中的关键合作伙伴作用
Stefanie Gijsels,Merlijn Vekeman,Suzanne Fischer et al.
Stefanie Gijsels et al.
Methods: Over the past five years, a bedside-to-bench flow was implemented in Ghent University Hospital for a living biobank of sarcoma tissue to support translational research.
Brain-derived textiloma post glioblastoma resection and application of oxidized regenerated cellulose: A pilot, bedside-to-bench, translational study [0.03%]
关于胶质母细胞瘤术后无菌性脑源性纺织异物并应用氧化再生纤维素的床边到实验室转化研究：一项初步研究
Joshua A Kra,Christopher Markosian,Fenny H F Tang et al.
Joshua A Kra et al.
Oxidized regenerated cellulose (ORC; marketed as Surgicel® and Tabotamp®) is routinely used as an intraoperative hemostatic agent. Rarely, residual ORC has been associated with a foreign body reaction generating cystic or granulomatous le...
Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy [0.03%]
甘皮素-3在肝癌治疗中的进展和挑战
Arnaud Couzinet,Toshihiro Suzuki,Tetsuya Nakatsura
Arnaud Couzinet
Reverse translation, bedside-to-bench research, is crucial to identify the factors that have hindered GPC3 target immunotherapies.
The Pivotal Role of Germline BRCA2 Pathogenic Variants in "Apparently Sporadic" Pancreatic Cancer [0.03%]
BRCA2 germline致病性变异在“散发型”胰腺癌中的关键作用
Jonathan R Brody,Alison P Klein
Jonathan R Brody
The innovative bedside-to-bench nature of this work revealed that individuals with these variants would be missed if genetic testing was limited only to those meeting the family history criteria.
Restoring energy metabolism by NAD+ supplement prevents alcohol-induced liver injury and boosts liver regeneration [0.03%]
补充NAD+恢复能量代谢可防治酒精性肝损伤并促进肝脏再生
Yao Liu,Cheng Cheng,Han Gao et al.
Yao Liu et al.
In this bedside-to-bench study, the protective effect of NAM against ALD was investigated by using the NIAAA mice model (chronic-plus-binge ethanol), and the liver regeneration boosting capability of NAM was evaluated by the partial hepatectomy mice model.
Actionable disease insights from bedside-to-bench investigation in fibrodysplasia ossificans progressiva [0.03%]
从床边到实验台的纤维发育不良进展调查所获得的行动见解
Marc N Wein,Yingzi Yang
Marc N Wein
Luciana Daniela Garlisi Torales,Benjamin A Sempowski,Georgia L Krikorian et al.
Luciana Daniela Garlisi Torales et al.
Basic, translational, and clinical science are essential for a bedside-to-bench and back approach for CCLA.
Rapid modeling of an ultra-rare epilepsy variant in wild-type mice by in utero prime editing [0.03%]
通过体内原位编辑快速构建超罕见癫痫变异的野生型小鼠模型
Colin D Robertson,Patrick Davis,Ryan R Richardson et al.
Colin D Robertson et al.
Leveraging the speed and versatility of this approach, we introduce PegAssist, a generalizable workflow to generate bedside-to-bench animal models of individual patients within weeks.
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