A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial-mesenchymal plasticity [0.03%]
无机砷诱发的癌症动态模型揭示了上皮-间充质可塑性的表观遗传机制
Matthew Rea,Greg Kimmerer,Shania Mittendorf et al.
Matthew Rea et al.
Inorganic arsenic (iAs) causes cancer by initiating dynamic transitions between epithelial and mesenchymal cell phenotypes. These transitions transform normal cells into cancerous cells, and cancerous cells into metastatic cells. Most in vi...
Tumor suppressive activity of AHR in environmental arsenic-induced carcinogenesis [0.03%]
芳烃受体在环境砷致肺癌发生中的肿瘤抑制作用研究
Ziwei Wang,Yao Fu,Akimasa Seno et al.
Ziwei Wang et al.
The aryl hydrocarbon receptor (AHR) is a highly conserved pleiotropic transcription factor that senses environmental pollutants, microbial products, and endogenous ligands. The transcriptional targets of AHR include phase I and phase II det...
Clonal variability in chromosomal instability as a potential driver in the acquisition of tumorigenic phenotype in chronic arsenic-exposed and hsa-miR-186 overexpressing human keratinocytes [0.03%]
克隆多态性染色体不稳定性作为慢性砷暴露和hsa-mir-186过度表达的人类角化细胞获得肿瘤表型的潜在驱动因素
Angeliki Lykoudi,Ana P Ferragut Cardoso,Sandra S Wise et al.
Angeliki Lykoudi et al.
These results suggest that clonal variability mediates arsenic-induced carcinogenesis in hsa-miR-186 overexpressing human keratinocytes.
Loss of MEG3 contributes to the enhanced migration and invasion in arsenic-induced carcinogenesis through NQO1/FSCN1 pathway [0.03%]
MEG3丢失通过NQO1/FSCN1途径促进砷致致癌过程中的肿瘤细胞迁移和侵袭
Huailu Tu,Zhuo Zhang,Jingxia Li et al.
Huailu Tu et al.
Arsenic ranks at the top among all toxic metals and poses a serious threat to human health. Inorganic arsenite and arsenate compounds have been classified as human carcinogens in various types of cancers. Maternally expressed gene 3 (MEG3),...
Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1 [0.03%]
无机砷通过HDAC6介导的HTRA1低表达促进恶性进展
Jiafeng Chen,Cece Lei,Daibang Nie et al.
Jiafeng Chen et al.
These findings provide valuable information for understanding the mechanisms of arsenic-induced carcinogenesis and facilitating the health management of populations in arsenic-polluted areas.
Alexandra N Nail,Ana P Ferragut Cardoso,Lakyn K Montero et al.
Alexandra N Nail et al.
Arsenic-induced carcinogenesis is a worldwide health problem. Identifying the molecular mechanisms responsible for the induction of arsenic-induced cancers is important for developing treatment strategies. MicroRNA (miRNA) dysregulation is ...
Ranakul Islam,Lei Zhao,Xiujuan Zhang et al.
Ranakul Islam et al.
Conclusion: Our study highlights the vital role of the miR-218-5p/EGFR signaling pathway in arsenic-induced carcinogenesis and angiogenesis, which may be helpful for the treatment of lung cancer induced by chronic arsenic exposure in the future.
Ranakul Islam,Lei Zhao,Yifang Wang et al.
Ranakul Islam et al.
Arsenic is a crucial environmental metalloid whose high toxicity levels negatively impact human health. It poses significant health concerns to millions of people in developed and developing countries such as the USA, Canada, Bangladesh, In...
New Discoveries and Ambiguities of Nrf2 and ATF3 Signaling in Environmental Arsenic-Induced Carcinogenesis [0.03%]
环境砷致癌中Nrf2和ATF3信号通路的新发现与不确定性
Zhuoyue Bi,Yao Fu,Priya Wadgaonkar et al.
Zhuoyue Bi et al.
Environment exposure to arsenic had been linked to increased incidents of human cancers. In cellular and animal experimental systems, arsenic has been shown to be highly capable of activating several signaling pathways that play critical ro...
ATF3 inhibits arsenic-induced malignant transformation of human bronchial epithelial cells by attenuating inflammation [0.03%]
ATF3通过减轻炎症抑制砷致人支气管上皮细胞的恶性转化
Qiwen Shi,Bei Hu,Chen Yang et al.
Qiwen Shi et al.
Understanding the mechanisms of arsenic-induced carcinogenesis favors the development of effective interventions to reduce the incidence and mortality of lung cancer.
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