Efficacy of External Siddha Pharmacotherapy for Giant Acrochordon: A Case Report [0.03%]
外用 Siddha 药物治疗巨大型皮赘的疗效观察：1 例报告
Saravanasingh Karan Chand Mohan Singh,Sugumaran Pichamuthu,V Gowri et al.
Saravanasingh Karan Chand Mohan Singh et al.
Pachaieruvai comprises five ingredients recognized for their cytotoxic properties, including arsenic trioxide and copper sulfate, which may assist in targeting abnormal cell growth.
Case Reports
Cureus. 2025 May 13;17(5):e84012. DOI:10.7759/cureus.84012 2025
Arsenic Trioxide Enhances the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway [0.03%]
三氧化二砷通过ROS/ERS途径诱导免疫原性细胞死亡增强PD-1抑制剂在肝癌中的疗效
Xionghui Wang,Simo Cheng,Yannan Xu et al.
Xionghui Wang et al.
Background: Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited efficacy of current immunotherapeutic strategies. Immunogenic cell death (ICD), characterized by the release of damage-assoc...
Mandibular Osteonecrosis Involving Tooth Germ in Children: a Rare Case Report with a 6-year Follow-up [0.03%]
儿童颌骨牙胚 involvement 的天疱疮性皮炎罕见病例报告及6年随访
Yue Fei,Guang Yun Lai,Jun Wang
Yue Fei
A healthy 4-year-old Chinese girl visited the clinic with an unhealed gingival wound and alveolar bone exposure of the missing primary molar area after 1-day arsenic trioxide sealing during pulp therapy. Radiographic examinations indicated inflammation and sequestrum formation in the jaw.
Acute promyelocytic leukaemia in a Nigerian patient-a case report depicting challenges in the management of haematological malignancies in Nigeria [0.03%]
尼日利亚一急性早幼粒细胞白血病患者病例报告：尼日利亚血液系统恶性肿瘤治疗中的问题分析
Lemchukwu C Amaeshi,Yusuf Adelabu,Olufunto Kalejaiye
Lemchukwu C Amaeshi
Treatment initiation with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) was delayed due to the unavailability of the medication locally and, therefore, had to be ordered from a different country.
Ao Zhang,Shaowei Qiu
Ao Zhang
The introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has significantly improved the complete remission rate in APL, making it a highly treatable disease.
PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance [0.03%]
PML1介导的通过PI3K和MAPK轴的前馈回路驱动内分泌耐药性
Han Wang,Zixi Yun,Yuan Cao et al.
Han Wang et al.
The clinical significance of our findings is threefold: we establish PML1 as a biomarker for therapy resistance, demonstrate its mechanistic role in treatment failure, and show that FDA-approved arsenic trioxide can disrupt PML1-driven resistance....These insights provide a direct path to clinical translation, as combining arsenic trioxide with existing therapies could benefit patients with limited treatment options.
A phase 2 study of decitabine with or without carboplatin and arsenic trioxide in patients with MDS and AML [0.03%]
地西他滨与卡铂和三氧化二砷联合治疗骨髓增生异常综合征和急性髓系白血病患者的II期研究
Patricia L Kropf,Woonbok Chung,Raji Shameem et al.
Patricia L Kropf et al.
Preclinical studies have indicated that arsenic trioxide (ATO) and carboplatin (Carbo) enhance DAC's epigenetic gene derepression. Consequently, we initiated a randomized phase 2 clinical trial evaluating DAC alone, or with Carbo or ATO, in patients with MDS/AML.
Clinical Trial
Blood neoplasia. 2025 Jan 23;2(2):100071. DOI:10.1016/j.bneo.2025.100071 2025
Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia [0.03%]
姜黄素联合三氧化二砷通过增强自噬和免疫监视抑制急性髓系白血病免疫逃逸
Meiling Zhang,Shupeng Chen,Yaru Cui et al.
Meiling Zhang et al.
Current research suggests that arsenic trioxide (Arsenic Trioxide, ATO) can regulate autophagy and upregulate NKG2D ligands (NKG2D-L) on the surface of AML cells, while the NKG2D-NKG2D-L axis is negatively associated with AML immune evasion.
CRISPR/Cas9-Based Modeling of JAK2 V617F Mutation in K562 Cells Reveals Enhanced Proliferation and Sensitivity to Therapeutic Agents [0.03%]
基于CRISPR / Cas9的JAK2 V617F突变在K562细胞中的建模揭示了增强的增殖和对药物治疗的敏感性
Nungruthai Nilsri,Rujira Mekchaaum,Supaporn Kalasin et al.
Nungruthai Nilsri et al.
Interferon α2a (IFN-α2a) and arsenic trioxide were also administered to the cells to explore their potential effects. The JAK2 V617F-mutated cells were found to exhibit a higher level of JAK2 gene expression compared with the wild type....Furthermore, the treatments with IFN-α2a and arsenic trioxide led to the preferential suppression of the cell proliferation rate of the K562 expressing mutant JAK2 cells compared with the wild type cells, and this suppression occurred in a dose-dependent manner(p < 0.01).
Uncovering dendritic cell specific biomarkers for diagnosis and prognosis of cardiomyopathy using single cell RNA sequencing and comprehensive bioinformatics analysis [0.03%]
利用单细胞RNA测序和全面生物信息学分析发现树突状细胞特异性生物标志物以诊断和预后心肌病
Md Mizanur Rahman,Md Habibur Rahman,Md Arju Hossain et al.
Md Mizanur Rahman et al.
Prospective chemical substances such as tretinoin, valproic acid, and arsenic trioxide have been predicted to be linked to cardiomyopathy treatment. The acceptable value of receiver operating characteristic (ROC) curve analysis revealed that biomarkers play critical roles in cardiomyopathy.
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