Residual Viral Expression in siRNA-Treated HBV-Replicating Cell and Mouse Models [0.03%]
siRNA治疗HBV复制细胞和小鼠模型中的残余病毒表达
Mingzhu Xu,Yuyan Qian,Ziyang Song et al.
Mingzhu Xu et al.
Biochemical methods, combined with immunofluorescence and fluorescent in situ hybridization techniques, were employed to analyze the antiviral effects of siRNAs targeting the S, X, and C coding regions of HBV at the single-cell level in HBV-infected HepG2-NTCP cell model and rAAV8-HBV1.3 mouse model....The antiviral effects of siRNA generally exhibit dose-dependent inhibition of HBV, but vary across different viral markers, potentially due to factors such as target region, engagement, and the viral expression patterns within cells, with a potential inhibition plateau for core particle DNA.
The interplay between STING and metabolic reprogramming: From mechanisms to therapeutic strategies [0.03%]
STING与代谢重编程的相互作用：从机制到治疗策略
Lu Zhou,Yu-Han Wang,Lu Zhang
Lu Zhou
The mechanisms of these regulatory pathways have been elucidated, and novel therapeutic approaches that target metabolic regulation to modulate the STING response have been proposed, thereby enhancing its downstream immune responses and promoting improved anti-tumor and antiviral effects in the body.
Translation: Management of Coronavirus Disease 2019 (COVID-19): Experience in Zhejiang Province, China [0.03%]
新冠肺炎疫情浙江省管控经验
Kaijin Xu,Hongliu Cai,Yihong Shen et al.
Kaijin Xu et al.
We found that lopinavir/ritonavir combined with abidol showed antiviral effects against COVID-19. Shock and hypoxemia were usually caused by cytokine storms. The artificial liver blood purification system was able to rapidly remove inflammatory mediators and block the cytokine storm.
Construction and In Vitro and In Vivo Analysis of Coxsackievirus B4 Reporter Viruses: Attenuated Virulence but Highly Efficient for Antiviral Drug Screening and Evaluation [0.03%]
柯萨奇病毒B4报告基因毒株的构建及其体内外分析：低致病性但高效的抗病毒药物筛选和评价模型
Qian Liu,Huan Wang,Xianglin Xuan et al.
Qian Liu et al.
In In Vivo drug evaluations, because CVB4 can infect various tissues and organs, the bioluminescence signal of rCVB4-NanoLuc effectively demonstrated the antiviral effects of drugs, offering significant advantages over traditional tissue viral titer analysis.
The Ran GTPase inhibits SGIV and RGNNV infection by upregulating host immune response in grouper [0.03%]
Ran GTP酶通过上调石斑鱼宿主免疫反应抑制SGIV和RGNNV感染
Xiaozhi Wen,Lingfeng Guan,Liqun Wang et al.
Xiaozhi Wen et al.
Taken together, EcRan showed the antiviral effects against SGIV and RGNNV infections by positively regulating innate immune response.
Antiviral effects of heme oxygenase-1 against canine coronavirus and canine influenza virus in vitro [0.03%]
犬冠状病毒和犬流感病毒体外实验中血红素氧合酶-1的抗病毒作用
Jae-Hyeong Kim,Dong-Hwi Kim,Kyu-Beom Lim et al.
Jae-Hyeong Kim et al.
Its antiviral effects are mediated not only by its enzymatic function but also through the modulation of interferon-related pathways, thereby inhibiting viral replication....In this study, we investigated the antiviral effects of HO-1 on canine coronavirus (CCoV) and canine influenza virus (CIV) H3N2 using cell-based assays. To determine whether HO-1 suppresses CCoV and CIV, cells were treated with hemin to induce HO-1 expression.
Voxtalisib inhibits enterovirus 71 replication by downregulating host RAN and restoring IFN-STAT signaling [0.03%]
voxtalisib通过下调宿主RAN蛋白并恢复IFN-Stat信号转导抑制肠道病毒71型复制
Wang Delong,Yang Qingyu,Zhu Guangyan et al.
Wang Delong et al.
Similar RAN-dependent p-STAT nuclear retention and antiviral effects were also observed against CVB and Echo11, confirming voxtalisib's broad-spectrum antiviral potential.
Dongdong Yin,Yayun Liu,Wei Liu et al.
Dongdong Yin et al.
Curcumin has been reported to exert antiviral effects against multiple viruses. However, its efficacy against DTMUV remains unclear. This study aimed to investigate the antiviral activity of curcumin against DTMUV both in vitro and in vivo....The antiviral effects of curcumin were evaluated using viral titration, qRT-PCR, Western blotting, and indirect immunofluorescence. In addition, a DTMUV-infected duck model was used to assess the therapeutic potential of curcumin in vivo.
Interferon-stimulated gene MCL1 inhibits foot-and-mouth disease virus replication by modulating mitochondrial dynamics and autophagy [0.03%]
干扰素诱导基因MCL1通过调节线粒体动力学和自噬抑制口蹄疫病毒增殖
Aishwarya Mogulothu,Danielle Hickman,Sarah Attreed et al.
Aishwarya Mogulothu et al.
This screen led to the identification of the potent antiviral effects of a relatively lesser-known ISG called MCL1. Our findings reveal that MCL1 exerts its antiviral functions through the regulation of mitochondrial dynamics and autophagy.
IL-37 Mitigates the Inflammatory Response in Macrophages Induced by SARS-CoV-2 Omicron Infection Through the NF-κB Signaling Pathway [0.03%]
白细胞介素37通过NF-κB信号通路缓解SARS-CoV-2奥密克戎感染诱导的巨噬细胞炎症反应
Feifei Qi,Yiwei Yan,Mingya Liu et al.
Feifei Qi et al.
Treatment with interleukin-37 (IL-37), an anti-inflammatory factor, has unique anti-inflammatory and antiviral effects on infections caused by various pathogens.
耗时 0.22236 秒，为您在
48206918
条记录里面共找到 3033 篇文章 [XML]