History of episodic heavy alcohol use predicts antidepressant effectiveness of ketamine [0.03%]
既往有重度饮酒史可预测氯胺酮抗抑郁疗效
Aaishah R Raquib,Vy Nguyen,Joshua C Brown et al.
Aaishah R Raquib et al.
Objective: We hypothesized that a personal history of episodic heavy drinking would positively correlate with antidepressant response to ketamine.
Early treatment-related changes in dorsolateral prefrontal cortex activity and functional connectivity as potential biomarkers for antidepressant response in major depressive disorder [0.03%]
作为抑郁症抗抑郁剂治疗反应潜在生物标志物的背外侧前额叶皮质活动及功能连接早期变化模式研究
Han Zhang,Cun Li,Ke Shi et al.
Han Zhang et al.
Cognitive deficits are prevalent in major depressive disorder (MDD). Given that the dorsolateral prefrontal cortex (DLPFC) is a crucial region within the executive control network, its activity and functional connectivity (FC) may serve as ...
Large-scale neural network correlates of response inhibition associated with antidepressant response in major depressive disorder [0.03%]
抑郁症患者抗抑郁治疗反应相关的抑制功能的大规模神经元网络关联研究
Haiyan Liu,Yi Xia,Xiaoqin Wang et al.
Haiyan Liu et al.
Background: A fundamental impairment of major depressive disorder (MDD) is response inhibition, which may serve as a predictor for inadequate responses to antidepressants. Nevertheless, the neurophysiological connections ...
Atypical depression is associated with a distinct clinical, neurobiological, treatment response and polygenic risk profile [0.03%]
非典型抑郁症与独特的临床表现、神经生物学特征、治疗反应和多基因风险特征相关
Mirim Shin,Jacob J Crouse,Tian Lin et al.
Mirim Shin et al.
Bonferroni-corrected regression models assessed associations between atypical depression and polygenic scores (PGS) for mental disorders, metabolic-inflammatory-circadian traits, and self-reported antidepressant response and side effects.
C-reactive Protein as an Indicator for Antidepressant Response in Late-Onset Depression [0.03%]
C反应蛋白作为晚发抑郁症抗抑郁药物治疗反应标志物的指示作用
Umesh Pratap Singh,Dheerendra Kumar Mishra,Ujwal Sardesai
Umesh Pratap Singh
Conclusions Late-onset depression was less responsive to antidepressant medication, and a poor antidepressant response rate was associated with a higher level of CRP in late-onset depression.
Independence of Peripheral Brain-Derived Neurotrophic Factor from Depression and Anxiety Symptoms in Cocaine Use Disorder: An Initial Description [0.03%]
外周脑源性神经营养因子与可卡因使用障碍患者的抑郁和焦虑症状无关：初步描述
Dannia M Islas-Preciado,Ruth Alcalá-Lozano,Erika P Aguilar-Velazquez et al.
Dannia M Islas-Preciado et al.
This finding suggests a singular, intricate regulation of peripheral BDNF and mood as part of CUD-related maladaptations that might disrupt the expected antidepressant response and perpetuate mood symptoms in CUD.
Transcriptomic activation of immune cell trafficking predicts antidepressant response to minocycline [0.03%]
小柴胡汤加减联合西药治疗抑郁症的临床研究及免疫转录组学分析
Luca Sforzini,Floriana De Cillis,Moira Marizzoni et al.
Luca Sforzini et al.
In this study, we investigate: i) the ability of transcriptomic profiles to predict antidepressant response to anti-inflammatory treatment with minocycline, and ii) the effect of minocycline on transcriptomic profiles based on the antidepressant response....A differential transcriptomic regulation, with activation of immune cell trafficking pathways, predicts antidepressant response to minocycline (but not placebo).
A plasma protein profile of antidepressant response to omega-3 fatty acids [0.03%]
欧米伽脂肪酸抗抑郁的蛋白组学标志物研究
Jesper Lindahl,Miranda Stiernborg,Filip Ventorp et al.
Jesper Lindahl et al.
Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactiv...
Predictive value of subgenual cingulate normative connectivity to TMS treatment site for antidepressant response in routine clinical practice: a prospective, multisite cohort study [0.03%]
基于多中心临床队列的预测价值：下扣带回结构连接规范性作为重复经颅磁刺激治疗靶点对抑郁障碍疗效的预测价值：一项前瞻性多中心队列研究
Sanaz Khosravani,Stephan T Palm,William Drew et al.
Sanaz Khosravani et al.
Small single-site studies found that transcranial magnetic stimulation (TMS) targets with better antidepressant response were more negatively functionally connected to the subgenual cingulate cortex (SGC). These led to "anti-subgenual" TMS targeting in recent clinical trials....No relationship was found between antidepressant response and normative connectivity of TMS site to SGC (r = 0.1, p = 0.39). This was not due to inconsistency in the location of the TMS sites, which showed smaller within- than between-individual variance (p < 0.0001)....Atlas-based connectivity of TMS site to the SGC accounted for minimal variance in antidepressant response in this diverse sample. The "anti-subgenual" target derived based on normative connectome may be suboptimal for MDD patients with high baseline anxiety or psychiatric comorbidities.
EEG microstates as indicators and predictors of response through 4 weeks of treatment in adolescents with major depressive disorder [0.03%]
青少年重度抑郁障碍患者治疗四周的脑电微状态指标及反应预测指标
Yaru Zhang,Tingyu Yang,Xilong Cui et al.
Yaru Zhang et al.
Conclusions: Microstate A may be associated with the severity of depressive symptoms, while microstate B might serve as a potent predictor of antidepressant response in adolescents with first-episode and drug-naive MDD.
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