Dual role of Japanese encephalitis virus fusion loop peptide antibodies in Zika virus infection [0.03%]
登革病毒融合肽抗体在寨卡病毒感染中的双重作用
Kexin Xi,Xuenan Zhang,Jingshu Li et al.
Kexin Xi et al.
Increased and decreased antibody levels respectively neutralized viral entry and replication, and facilitated infection via antibody-dependent enhancement (ADE).
Dengue Virus-Susceptible Animal Models: Research Progress, Core Bottlenecks, and Future Perspectives [0.03%]
登革病毒易感动物模型的研究进展、核心瓶颈及未来前景
Wensheng Zhang,Yue Zhao,Teng Meng et al.
Wensheng Zhang et al.
These limitations make it difficult to accurately replicate key severe disease mechanisms, including antibody-dependent enhancement (ADE) and cytokine storms.
Retrospective neutralization analysis of SARS-CoV-2 variants in early pandemic sera [0.03%]
早期大流行血清中的SARS-CoV-2变异株的回顾性中和分析
Mohamed Mahdi,Aya S Al-Muffti,Tamás Richárd Linkner et al.
Mohamed Mahdi et al.
We also investigated the potential for antibody-dependent enhancement (ADE) in monocyte-derived macrophages.
The contributions of TLR2, TLR8 and TLR3 to direct and antibody-dependent enhancement of dengue virus serotype 2 infection [0.03%]
TLR2、TLR8和TLR3在登革病毒二型直接感染及抗体依赖性增强作用中的贡献
B M Ter Ellen,M Punekar,J A Castillo et al.
B M Ter Ellen et al.
Antibody-dependent enhancement (ADE) of dengue virus-type 2 (DENV2) is a major risk factor for severe disease, facilitating Fcγ receptor-mediated viral entry and triggering inflammation that compromises vascular integrity. While Toll-like ...
CD8+ T cells and Humoral Immunity Influence the Development of Antibody-Dependent Enhancement: Implications for Vaccine Design [0.03%]
细胞毒性T细胞和体液免疫影响抗体依赖性增强作用的发展：对疫苗设计的意义
Riley Drake,Hasan Ahmed,Anmol Chandele et al.
Riley Drake et al.
In contrast, low-to-intermediate dengue-specific antibody titers can enhance viral replication and increase disease severity-a phenomenon known as antibody-dependent enhancement (ADE).
Mathematical modeling of sequential Dengue-Zika infections: dynamic insights into antibody-dependent enhancement and neutralization effects [0.03%]
登革热-寨卡病毒序列感染的数学建模：抗体依赖性增强和中和作用的动力学见解
Preeti Deolia,Anuraj Singh,Anuj Mubayi
Preeti Deolia
Inactivated Japanese encephalitis virus vaccination imprints fusion loop-biased antibody responses that are attenuated by repeated live-attenuated dengue vaccination [0.03%]
灭活日本脑炎病毒疫苗引发以融合肽位点为主的抗体应答，而重复接种减毒登革热活疫苗则使该应答减弱
Patrick I Mpingabo,Esther I Adekomi,Lisa A Ware et al.
Patrick I Mpingabo et al.
Notably, 4G2 FLE-focused responses correlated with higher FcγRIIa-mediated antibody-dependent enhancement relative to neutralization potency, suggesting functional effects beyond neutralization.
Bridging Gaps in Dengue Management: A Review of Diagnostics, Transfusion Needs, and Public Health Challenges [0.03%]
登革管理中的缺口：诊断、输血需求及公共卫生挑战综述
Ghazi Khairallah Alanazi,Yasir Awad Ahmed,Yousef Alobaisi
Ghazi Khairallah Alanazi
Background: Dengue fever remains a major global public health challenge, particularly in endemic regions, due to its complex clinical presentation, diagnostic limitations, evolving epidemiology, and immunopathogenic mechanisms such as antibody-dependent enhancement (ADE).
Sub-neutralizing concentrations of Zika virus IgM monoclonal antibodies reduce IgG-mediated antibody-dependent enhancement of infectivity [0.03%]
寨卡病毒IgM单克隆抗体的亚中和浓度可降低IgG介导的抗体依赖增强感染性
Matthias Lingemann,Taylor J McGee,Giacomo Sidoti Migliore et al.
Matthias Lingemann et al.
Zika virus (ZIKV) is an arthropod-borne flavivirus endemic to Latin America and Africa for which IgG-mediated antibody-dependent enhancement of infectivity (ADE) is a phenomenon of concern. The interplay dynamics between flavivirus-specific antibodies of the IgG and IgM isotypes are mostly unknown.
SARS-CoV-2 antibody-dependent enhancement of infection depends on antibody binding to both ACE2 and Fc receptors [0.03%]
SARS-CoV-2抗体介导的感染增强作用取决于ACE2和Fc受体结合
Natalia A Kuzmina,Sivakumar Periasamy,Kritika Kedarinath et al.
Natalia A Kuzmina et al.
Antibody-dependent enhancement (ADE) of infection is a well-described phenomenon for several viruses, including dengue, Ebola, respiratory syncytial virus, and HIV. ADE occurs when virus-antibody complexes engage Fc receptors (FcRs) and vir...
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