Distinct platelet phenotype and reactivity in individuals with permanent atrial fibrillation treated with direct oral anticoagulants: a pilot study [0.03%]
直接口服抗凝治疗永久性心房颤动患者的血小板表型和反应性的异质性：一项试点研究
Marzia Miglionico,Francesca Maiorca,Annamaria Sabetta et al.
Marzia Miglionico et al.
Background: Atrial fibrillation (AF) is an age-related disease linked to an elevated risk of thromboembolic events.
Sweet Aging: Glycocalyx and Galectins in CNS Aging and Neurodegenerative Disorders [0.03%]
糖基化老化：中枢神经系统老化和神经退行性疾病的糖萼与半乳糖凝集素的作用
Mohd Yaqub Mir,Adam Legradi
Mohd Yaqub Mir
Genomic studies indicate that the number of galectin-1- and galectin-3-expressing microglial cells increases with age- or age-related disease (Alzheimer's disease), reflecting an aging-associated rise in galectin concentrations within the CNS.
Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation [0.03%]
CHIP相关基因的表观遗传学研究为解析发病机制提供新思路
Sara Kirmani,Tianxiao Huan,Joseph C Van Amburg et al.
Sara Kirmani et al.
Taken together, our study reports the epigenetic changes impacted by CHIP and their associations with age-related disease outcomes. © 2025. This is a U.S.
Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice [0.03%]
苯乙基异硫氰酸酯通过靶向活化衰老特异性分泌表型中的AKT通路诱发老年小鼠慢性肺纤维化的衰老细胞溶解疗法
Rui Wang,Fan Yang,Ying Liu et al.
Rui Wang et al.
Discussion: Our study reveals that BITC may be a promising therapeutic option for IPF and other age-related disease that progress with the accumulation of senescent fibroblasts.
Inhibition of DLK1 regulates AT2 differentiation and alleviates established pulmonary fibrosis by upregulating TTF-1/CLDN6 [0.03%]
DLK1抑制通过上调TTF-1/CLDN6促进ATII分化并改善既往肺纤维化
Yinzhen Li,Chen Zhou,Jiaxing Sun et al.
Yinzhen Li et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a devastating age-related disease with unknown causes and limited effective treatment. Dysregulation of Alveolar Type 2 (AT2) cells facilitates the initiation of IPF.
Gromwell (Lithospermum erythrorhizon) ameliorates age-related loss of skeletal muscle mass and function in mice [0.03%]
牻牛儿苗通过改善小鼠与年龄相关的肌肉损失和功能障碍而增肌
Ahyoung Yoo,Lynn Ahn,Hyunjung Lee et al.
Ahyoung Yoo et al.
Sarcopenia, an age-related disease characterized by the loss of skeletal muscle mass and function, is a growing concern in the aging population.
Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis [0.03%]
间断的限时饮食可能会增加人类的自噬通量：一项探索性分析
Julien Bensalem,Xiao Tong Teong,Kathryn J Hattersley et al.
Julien Bensalem et al.
KEY POINTS: Autophagy slows biological ageing, and dysfunction of autophagy has been implicated in age-related disease - an effective way of increasing autophagy in cells and animal models is nutrient restriction.
Biomarkers of oxidative and mitochondrial stress are associated with accelerated pace of aging at midlife in a birth cohort [0.03%]
氧化应激和线粒体损伤生物标志物与出生队列中成年人群中年期间加速衰老相关
Te-Rina J King-Hudson,Andree G Pearson,Caitlin Dunstan-Harrison et al.
Te-Rina J King-Hudson et al.
These associations remained when the limited number of participants with age-related disease were removed from the analyses.
Alexander Mörseburg,Yajie Zhao,Katherine A Kentistou et al.
Alexander Mörseburg et al.
This metric is strongly associated with four age-related disease outcomes, even after adjusting for chronological age. Survival analysis showed that one-year older proteomic age, relative to chronological age, increases all-cause mortality hazard by 13 percent.
Canine-derived Weissella confusa ZJUIDS-D034 and Enterococcus faecalis ZJUIDS-D016 combat aging by regulating gut microbiota [0.03%]
犬来源的Weissella confusa ZJUIDS-D034和Enterococcus faecalis ZJUIDS-D016通过调节肠道菌群对抗衰老
Nan Chen,Zexu Yu,Xuan Ji et al.
Nan Chen et al.
Old age raises the susceptibility of age-related disease in domestic dogs. Discovering effective anti-aging interventions is key for mitigating age-related disease and conserving "healthspan" in pet dogs. In this study, 2 bacterial strains were isolated from canine feces.
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