Assisted reproduction with advancing paternal and maternal age: an Ethics Committee opinion [0.03%]
高龄夫妇辅助生殖的伦理问题——伦理委员会的观点
ASRM Ethics Committee. Electronic address: asrm@asrm.org
ASRM Ethics Committee. Electronic address: asrm@asrm.org
Ethical considerations for developing policies regarding providing assisted reproductive care to individuals of advanced reproductive age are complex; considerations include both reproductive autonomy and the well-being of the potential offspring.
Carlo Alviggi,Luigi Vigilante,Federica Cariati et al.
Carlo Alviggi et al.
Furthermore, women of advanced reproductive age present a less functional LH system and consequently reduced androgen production....Reduced ovarian sensitivity and advanced reproductive age represent the main criteria proposed by the POSEIDON group to identify women with impaired prognosis when undergoing ART.
Enhanced Ovarian FKBP51 Expression is Associated with Ovarian Aging: A Molecular Insight for Age-Related Fertility in Women [0.03%]
卵巢FKBP51表达增强与卵巢衰老相关：女性年龄相关生育能力的分子见解
Papri Sarkar,Monica Moore,Asli Ozmen et al.
Papri Sarkar et al.
To study the relationship between FK506-binding protein 51 (FKBP51) and ovarian aging and/or diminished ovarian reserve (DOR) in human ovaries by comparing FKBP51 levels in granulosa (GC) and cumulus cells (CC), collected during controlled ovarian stimulation (COS) from women of advanced...reproductive age and/or with a diagnosis of DOR with that of young women with normal ovarian reserve.
"It was a foregone conclusion": a qualitative study of women's experiences and meaning-making of later-in-life abortion in Belgium [0.03%]
"顺理成章"的结果：比利时晚年流产的女性体验和意义生成的质性研究
Kato Verghote,Nathalie Neeser,Tenzin Wangmo et al.
Kato Verghote et al.
It highlights the need to destigmatise the topic and the importance for professionals and researchers to consider family preservation and advanced reproductive age as potential factors shaping abortion decision-making.
Effects of preimplantation genetic testing for aneuploidy on embryo transfer outcomes in women of advanced reproductive age with no more than three retrieved oocytes [0.03%]
胚胎植入前非整倍体筛查对年龄较大且获卵数不超过3个的女性冻胚移植结局的影响分析
Zhanhui Ou,Nengqing Liu,Ang Chen et al.
Zhanhui Ou et al.
Objective: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) benefits women of advanced reproductive age (≥38 years old) with a diminished ovarian reserve (not more than three retrieved oocytes)....Conclusion: Although PGT-A improved clinical pregnancy and live birth rates per transfer cycle in women of advanced reproductive age with a low oocyte yield, it did not impact these rates per retrieval.
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in In-Vitro Fertilisation (IVF) Treatment: Study Protocol for Pilot Phase of a Randomised Controlled Trial [0.03%]
胚胎植入前非整倍体遗传学检测（PGT-A）在体外受精中的临床应用：随机对照试验的试点研究方案
Yusuf Beebeejaun,Kypros H Nicolaides,Anastasia Mania et al.
Yusuf Beebeejaun et al.
None of the existing studies solely included women of advanced reproductive age (ARA).
Spontaneous conception in a 40-year-old woman after allogeneic stem cell transplant with active graft-versus-host disease: A case report [0.03%]
造血干细胞移植后移植物抗宿主病活动期40岁女性自然妊娠一例
Lauren Barrison,Selena Park,Alan Decherney
Lauren Barrison
This case demonstrates the potential for ovarian recovery after stem allogenic cell transplant in a patient of advanced reproductive age and provides insight into the limited knowledge about graft-versus-host disease in pregnancy.
Conditional loss of Brca1 in oocytes causes reduced litter size, ovarian reserve depletion and impaired oocyte in vitro maturation with advanced reproductive age in mice [0.03%]
卵巢细胞条件性Brca1缺失小鼠卵子质量受损的表型及相关机制研究
Amy L Winship,Lauren R Alesi,Jessica M Stringer et al.
Amy L Winship et al.
Background: An estimated 1 in 350 women carry germline BRCA1/2 mutations, which confer an increased risk of developing breast and ovarian cancer, and may also contribute to subfertility. All mature, sex steroid-producing ...
In vitro fertilization and perinatal outcomes of patients with advanced maternal age after single frozen euploid embryo transfer: a propensity score-matched analysis of autologous and donor cycles [0.03%]
体外受精后的高龄产妇单个冷冻整倍体胚胎移植的围生期结局：自身周期与捐赠周期倾向性评分匹配分析
Mauro Cozzolino,Antonio Capalbo,Juan Antonio Garcia-Velasco et al.
Mauro Cozzolino et al.
Objective: To evaluate in vitro fertilization (IVF) and perinatal outcomes of donor egg and autologous cycles in patients with advanced reproductive age after undergoing single frozen euploid embryo transfer....These findings suggest that age-related reproductive decline and/or poor IVF outcomes associated with women with advanced reproductive age undergoing IVF are heavily driven by embryonic aneuploidy.
The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial [0.03%]
白藜芦醇对体外受精结局影响的安慰剂对照随机探索性试验
A Conforti,G G Iorio,R Di Girolamo et al.
A Conforti et al.
Conclusions: Preliminary results from this study indicate that pre-treatment with resveratrol may improve ovarian sensitivity to exogenous FSH, which in turn may decrease the risk of hypo-response to OS in advanced reproductive age women.
Randomized Controlled Trial
Journal of ovarian research. 2024 Apr 15;17(1):81. DOI:10.1186/s13048-024-01391-7 2024
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