Rapid and non-invasive renal injury diagnosis unlocked by a glimpse into urinary protein particle size and charge [0.03%]
尿蛋白颗粒大小和电荷的测定实现快速无创性肾损伤诊断
Duanna Zeng,Bing Wang,Yanhong Guo et al.
Duanna Zeng et al.
Additionally, the sensor could also evaluate the effect of Huangkui capsule on kidney injury in adriamycin nephropathy model mice.
C-X-C chemokine receptor type 4 promotes tubular cell senescence and renal fibrosis through β-catenin-inhibited fatty acid oxidation [0.03%]
C-X-C趋化因子受体4通过抑制β-连环蛋白的脂肪酸氧化促进肾小管细胞衰老和肾纤维化
Qinyu Wu,Qiurong Chen,Dan Xu et al.
Qinyu Wu et al.
In this study, we adopted adriamycin nephropathy and 5/6 nephrectomy models, and cultured tubular cell line. Overexpression or knockdown of CXCR4 was obtained by injection of related plasmids. We identified CXCR4 increased in injury tubular cells.
CDDO-Me ameliorates podocyte injury through anti-oxidative stress and regulation of actin cytoskeleton in adriamycin nephropathy [0.03%]
CDDO-Me通过抗氧化应激和调节肌动蛋白细胞骨架缓解阿霉素肾病中的足细胞损伤
Cheng Xu,Xing Liu,Xiuwen Zhai et al.
Cheng Xu et al.
Podocyte injury is the common initiating event in focal segmental glomerulosclerosis (FSGS). Oxidative stress and inflammation mediate podocyte injury in FSGS. NRF2 pathway regulates the constitutive and inducible transcription of various g...
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis [0.03%]
美尼雷德联合抗ANGPTL3-FLD单克隆抗体通过促进自噬和抑制凋亡完全保护阿霉素肾病小鼠
Baowei Ji,Junchao Liu,Ye Yin et al.
Baowei Ji et al.
Angiopoietin-like protein 3 (Angptl3) is an essential target of NS, and anti-ANGPTL3-FLD monoclonal antibody (mAb) significantly reduces proteinuria in mice with adriamycin nephropathy (AN). However, some proteinuria is persistent.
Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy [0.03%]
肝素酶-2蛋白及多肽对实验性肾小球肾炎和糖尿病肾病的保护作用
Baranca Buijsers,Marjolein Garsen,Mark de Graaf et al.
Baranca Buijsers et al.
Methods: First, we evaluated the regulation of HPSE2 expression in anti-GBM and LPS-induced glomerulonephritis, streptozotocin-induced diabetic nephropathy, and adriamycin nephropathy by qPCR and ELISA.
Minnelide Markedly Reduces Proteinuria in Mice with Adriamycin Nephropathy by Protecting Against Podocyte Injury [0.03%]
没奈美通过保护足细胞减少阿霉素肾病蛋白尿作用的研究
Baowei Ji,Junchao Liu,Yanli Ma et al.
Baowei Ji et al.
Minnelide was administered intraperitoneally to 6-8-week female mice with adriamycin nephropathy for 2 weeks, and the urine, blood, and kidney tissues were taken to analyze the therapeutic effect.
Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuria [0.03%]
过氧化物酶体增殖激活受体γ激动剂介导的肝素酶表达抑制可降低蛋白尿水平
Marjolein Garsen,Baranca Buijsers,Marloes Sol et al.
Marjolein Garsen et al.
Methods: Regulation of HPSE by PPARɣ was assessed in the adriamycin nephropathy rat model, and cultured glomerular endothelial cells and podocytes. Analyses included immunofluorescence staining, real-time PCR, heparanase activity assay and transendothelial albumin passage assay.
Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways [0.03%]
米诺利德与Angptl3基因敲除通过抑制TGF-β1-Smad2和p53信号通路完全保护阿霉素肾病小鼠模型
Baowei Ji,Junchao Liu,Yanli Ma et al.
Baowei Ji et al.
Our group found that Angiopoietin-like protein 3 (Angptl3) is closely related to renal disease and Angptl3 knockout significantly alleviated proteinuria in mice with adriamycin nephropathy (AN), however, some proteinuria was still present.
A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells [0.03%]
一种新的LKB1激活剂S14（劈缘酸类似物）通过促进肾小管上皮细胞自噬和线粒体稳态延缓肾纤维化
Canzhen Liu,Xiaoxu Wang,Xiaonan Wang et al.
Canzhen Liu et al.
We adopted various CKD models or AKI-CKD model (5/6 nephrectomy, UUO, UIRI and adriamycin nephropathy models). TGF-β-stimulated renal tubular cell culture was also tested.
Genetic background strongly influences the transition to chronic kidney disease of adriamycin nephropathy in mice [0.03%]
遗传背景强烈影响小鼠阿霉素肾病向慢性肾脏疾病转变
Masaki Watanabe,Koki Hiura,Hayato Sasaki et al.
Masaki Watanabe et al.
Animal models of podocytopathy and chronic kidney diseases (CKD) help elucidate these pathologies. Adriamycin (ADR)-induced nephropathy is a common rodent model of podocytopathy. BALB/c mice are sensitive to ADR, whereas C57BL/6 (B6) mice, ...
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