mGluR5 in Pyramidal Neurons in the Hippocampus Mediates Chronic Stress-Induced Memory Deficits [0.03%]
Ⅴ型代谢型谷氨酸受体在海马锥体神经元中的作用及其介导慢性应激所致记忆缺损的机制研究
Hong-Cheng Lu,Zhuo-Jun Du,Hao Chen et al.
Hong-Cheng Lu et al.
Furthermore, we identify that pituitary adenylyl cyclase activating peptide (PACAP) is down-regulated after CRS and mGluR5 knockdown. PACAP application could restore the impaired inhibitory synaptic inputs after CRS.
Kidney cystogenesis in embryonic- and adult-onset ADPKD is suppressed from lack of adenylyl cyclase targeting to cilia [0.03%]
胚胎期和成人期发生的常染色体显性多囊肾病的肾脏囊肿发生由于腺苷酸环化酶定位到纤毛受阻而被抑制
Sun-Hee Hwang,Kyungsuk Choi,Hemant Badgandi et al.
Sun-Hee Hwang et al.
Here we aimed at differentiating ciliary adenylyl cyclase signaling from total cellular changes in second messenger cAMP implicated in cystogenesis.
GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake [0.03%]
GPR45通过调节下丘脑室旁核初级纤毛中的Gαs来控制摄食行为
Yu Xun,Yiao Jiang,Baijie Xu et al.
Yu Xun et al.
The melanocortin system centrally regulates energy homeostasis, with key components such as melanocortin-4 receptor (MC4R) and adenylyl cyclase 3 (ADCY3) in neuronal primary cilia.
Structural insights into human adenylyl cyclase 9 in complex with Gαs by cryo-EM [0.03%]
人类腺苷酸环化酶9与Gαs复合物的冷冻电镜结构解析
Risa Nomura,Shota Suzuki,Koki Nishikawa et al.
Risa Nomura et al.
Adenylyl cyclase 9 (AC9) regulates many physiologic functions through the production of cAMP, an important second messenger that regulates downstream effectors. The activation of AC9 is highly regulated by GCPR signaling. For example, AC9 i...
Adenylyl Cyclase Activator: Forskolin Mediates CREB ser133 Phosphorylation in the Hippocampus, Alleviates Autism-Like Deficits in a Valproic Acid Model of Wistar Rats [0.03%]
佛司可林激活肾上腺素受体偶联G蛋白活化腺苷酸环化酶，介导威斯特大鼠脑内海马区CREB磷酸化，改善其自闭症缺陷模型中的核心症状及其相关行为学异常机制的研究
Ashish Jain,Neha Dhir,Praisy K Prabha et al.
Ashish Jain et al.
It is a potent adenylyl cyclase (AC) activator, increases intracellular cyclic adenosine monophosphate (cAMP) levels, thereby activating the protein kinase A (PKA)/CREB pathway with clinically proven benefits as an anticancer, anti-asthmatic, and in metabolic disorder, and crosses the blood-brain-barrier
Extracellular ATP increases agonist potency and reduces latency at class B G protein-coupled receptors [0.03%]
胞外环腺苷酸增加B类G蛋白偶联受体激动剂的效价并减少其潜伏期
Shuying Zhu,Alice Yuan,Tristan Duffy et al.
Shuying Zhu et al.
Thus, ATP both increases the potency of orthosteric agonists at class B GPCRs and reduces latency for adenylyl cyclase activation....SIGNIFICANCE STATEMENT: In addition to acting as a positive modulator of PTH1R signaling, extracellular ATP increases the potency of orthosteric agonists at other class B GPCRs and reduces the latency for adenylyl cyclase activation.
Caffeine plays a prevention role in stress-induced depression by modulating gut-brain axis function [0.03%]
咖啡因通过调节肠-脑轴功能发挥压力诱导的抑郁的预防作用
Wentao Wu,Jiaolin Wang,Jianjun Chen et al.
Wentao Wu et al.
not observed in CAF group; and the altered levels of two inflammation factors in plasma (lipopolysaccharide (LPS) and NOD-like receptor thermal protein domain-associated protein 3 (NLRP3)) and four inflammation-related factors in hippocampus (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), adenylyl...cyclase (AC) and brain-derived neurotrophic factor (BDNF)) in CUS group were not observed in CAF group.
Mediation Mendelian randomization analysis of immune cell phenotypes and glioma risk: unveiling the regulation of cerebrospinal fluid metabolites [0.03%]
髓母细胞瘤和免疫细胞表型的中介孟德尔随机化分析：脑脊液代谢物调节作用的揭示
Siyuan Zhao,Jinghao Jiang,Jianwu Zhang et al.
Siyuan Zhao et al.
Furthermore, Glycerophosphoinositol levels (MP = - 12.1%) and Orotate levels (MP = - 11.4%) partially mediated the relationship between Granulocyte adenylyl cyclase (Granulocyte AC) and glioma.
Exploring the Connection Between BDNF/TrkB and AC/cAMP/PKA/CREB Signaling Pathways: Potential for Neuroprotection and Therapeutic Targets for Neurological Disorders [0.03%]
BDNF/TrkB信号通路与AC/cAMP/PKA/CREB信号通路的联系：神经系统保护和治疗靶点的潜在作用机制研究
Abhishek Kumar Gupta,Sumedha Gupta,Sidharth Mehan et al.
Abhishek Kumar Gupta et al.
Key components of the path, including adenylyl cyclase and cyclic AMP, mediate the effects of neurotransmitters and growth factors, influencing downstream targets like PKA and CREB, which are crucial for gene expression and synaptic changes.
Bovine serum albumin-induced calcium influx triggers soluble adenylyl cyclase activation and cyclic AMP signalling pathways in mouse sperm capacitation [0.03%]
补体系统的激活触发钙离子流入并参与诱导小鼠精子获能过程中的可溶型腺苷酸环化酶和环磷酸腺苷信号通路
Guillermina M Luque,Martina Jabloñski,Liza J Schiavi-Ehrenhaus et al.
Guillermina M Luque et al.
A critical regulator of capacitation, the soluble adenylyl cyclase (sAC; ADCY10)-dependent production of the second messenger cyclic AMP (cAMP), drives key downstream events such as protein kinase A (PKA) substrate phosphorylation. sAC activity is directly stimulated by bicarbonate (HCO3 -) and calcium
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