Long noncoding RNA ZRANB2-AS2 promotes endothelial cell dysfunction by inhibiting phosphorylation of acetyl-CoA carboxylase 1 in diabetes [0.03%]
长非编码RNA ZRANB2-AS2通过抑制乙酰辅酶A羧化酶1磷酸化促进糖尿病血管并发症中的内皮细胞功能障碍
Tianchi Chen,Bing Wang,Donglin Li et al.
Tianchi Chen et al.
LncRNA has been implicated in the regulation of diabetes. We identified a novel lncRNA that inhibits phosphorylation of acetyl-CoA carboxylase 1 to modulate the dysfunction of vascular endothelial cells under high glucose conditions. In vit...
Depletion of Acetyl-CoA Carboxylase 1 Facilitates Epithelial-Mesenchymal Transition in Prostate Cancer Cells by Activating the MAPK/ERK Pathway [0.03%]
乙酰辅酶A羧化酶1的耗竭通过激活MAPK / ERK通路促进前列腺癌上皮间质转化
Jiarun Lai,Shaoyou Liu,Yupeng Chen et al.
Jiarun Lai et al.
Hyperactivation of fatty acid biosynthesis holds promise as a targeted therapeutic strategy in prostate cancer (PCa). However, inhibiting these enzymes could potentially promote metastatic progression in various other cancers. Herein, we fo...
MiR-24-3p enhances the Treg/Th17 balance to improve cerebral ischemic injury by suppressing acetyl-CoA carboxylase 1 expression [0.03%]
miR-24-3p通过抑制乙酰辅酶A羧化酶1表达来改善脑缺血损伤并促进Treg/Th17平衡
Yong Wang,Yan Yang,Lijun Xie et al.
Yong Wang et al.
Background: Targeting ACC1 (acetyl coenzyme A carboxylase 1) to restore the balance between T-helper 17 (Th17) cells and regulatory T cells (Tregs) through metabolic reprogramming has emerged as a promising strategy for r...
Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER+ breast cancer [0.03%]
乙酰辅酶A羧化酶1控制脂滴-过氧化物酶体轴，是内分泌抵抗的ER阳性乳腺癌的弱点
Marina Bacci,Nicla Lorito,Alfredo Smiriglia et al.
Marina Bacci et al.
Targeting aromatase deprives ER+ breast cancers of estrogens and is an effective therapeutic approach for these tumors. However, drug resistance is an unmet clinical need. Lipidomic analysis of long-term estrogen-deprived (LTED) ER+ breast ...
Corrigendum to "Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis" [Biochim. Biophys. Acta Mol. Basis Dis. 1869 (5) (2023) 166694 (PMID: 36972768)] [0.03%]
关于“减少乙酰辅酶A羧化酶1通过AMPK-NF-κB-snail轴减弱CCA迁移[Biochim. Biophys. Acta Mol. Basis Dis. 1869 (5) (2023) 166694 (PMID: 36972768)]的勘误表
Saowaluk Saisomboon,Ryusho Kariya,Piyanard Boonnate et al.
Saowaluk Saisomboon et al.
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [0.03%]
乙酰辅酶A羧化酶1是脂肪细胞产热程序的抑制因子
Adilson Guilherme,Leslie A Rowland,Nicole Wetoska et al.
Adilson Guilherme et al.
Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malony...
Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD [0.03%]
丙酮酸羧化酶的琥珀酰化促进非酒精性脂肪肝中肝脏脂肪变性并被生酮饮食抑制
Huanyi Cao,Qingxian Cai,Wanrong Guo et al.
Huanyi Cao et al.
Protein post-translational modifications (PTMs) participate in important bioactive regulatory processes and therefore can help elucidate the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here, we investigate the involvement of ...
Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis [0.03%]
乙酰辅酶A羧化酶1通过AMPK-NF-κB-Snail轴调节胆道癌细胞迁移并可作为潜在的治疗靶点
Saowaluk Saisomboon,Ryusho Kariya,Piyanard Boonnate et al.
Saowaluk Saisomboon et al.
Cholangiocarcinoma (CCA), a cancer of the biliary tract, is a significant health problem in Thailand. Reprogramming of cellular metabolism and upregulation of lipogenic enzymes have been revealed in CCA, but the mechanism is unclear. The cu...
Yong Yu,Qingzhu Nie,Ziyi Wang et al.
Yong Yu et al.
Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecu...
Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells [0.03%]
乙酰CoA羧化酶1耗尽抑制去势抵抗性前列腺癌细胞从头脂肪酸合成和线粒体β氧化
Shaoyou Liu,Jiarun Lai,Yuanfa Feng et al.
Shaoyou Liu et al.
Cancer cells, including those of prostate cancer (PCa), often hijack intrinsic cell signaling to reprogram their metabolism. Part of this reprogramming includes the activation of de novo synthesis of fatty acids that not only serve as build...
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