Eicosapentaenoic acid alleviates fibromyalgia-like pain by modulating microglia, astrocytes, and toll-Like receptor 4 signaling in the mice cerebellum [0.03%]
二十碳五烯酸通过调节小鼠小脑中的微胶质细胞、星形胶质细胞和TLR4信号减轻类纤维肌痛疼痛
I-Han Hsiao,Hsin-Cheng Hsu,I-Ying Lin et al.
I-Han Hsiao et al.
Fibromyalgia (FM) is a widespread systemic pain disorder often accompanied by symptoms such as insomnia, mania, obesity, and depression. FM is difficult to diagnose and, therefore, cannot be effectively treated with current medical approach...
CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury [0.03%]
CMTM7通过促进Rab5活化抑制TLR4信号通路并缓解急性肝损伤
Yingzhe Sun,Zixia Guo,Yangbo Huo et al.
Yingzhe Sun et al.
The activation of macrophages mediated by TLR4 is crucial for innate immune responses, while the regulatory mechanisms of TLR4 are still under investigation. This study demonstrates that CMTM7 inhibits TLR4 pathway activation in macrophages...
CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury [0.03%]
CYLD通过连接TRAF6/sNASP轴参与脓毒症诱导的急性肺损伤中的TLR4信号通路
Yu-Chih Wu,Bing-Hua Su,Wun-Hao Cheng et al.
Yu-Chih Wu et al.
Sepsis-induced acute lung injury (ALI) involves severe lung dysfunction and leads to high morbidity and mortality rates due to the lack of effective treatments. The somatic nuclear autoantigenic sperm protein (sNASP)/tumor necrosis factor r...
Synergism between TLR4 and B. infantis in the development of the premature intestine [0.03%]
TLR4与B.infantis在早产肠发育中的协同作用
Wuyang Huang,Karim Djebali,Ky Young Cho et al.
Wuyang Huang et al.
Background: Intestinal microbiota has a role in early life maturation including maturation of intestinal immune function. However, the interaction of the TLR4 with colonizing bacteria in intestinal development is incomple...
Amelioration of Toll-like Receptor-4 Signaling and Promotion of Mitochondrial Function by Mature Silkworm Extracts in Ex Vivo and in Vitro Macrophages [0.03%]
家蚕成熟期提取物改善体外和体内巨噬细胞的TLR-4信号并促进线粒体功能
Trinh Yen Binh Phan,Byungki Jang,Sang-Kuk Kang et al.
Trinh Yen Binh Phan et al.
Objectives: The unknown immune-enhancing effects of steamed mature silkworms (Bombyx mori L.), known as HongJam (HJ), were investigated. Methods: ...
Tocotrienol suppresses colitis-associated cancer progression through TLR4 signaling in a mouse model of colorectal cancer [0.03%]
托考 triene通过TLR4信号传导抑制结肠炎相关癌症的进展：一项结直肠癌小鼠模型研究
Qian Li,Shujing Zhang,Qinghong Zhou et al.
Qian Li et al.
This study aimed to evaluate the preventive efficacy of tocotrienol in inhibiting the nuclear factor-kappa B (NF-κB) mediated inflammation pathways in colorectal cancer. We utilized the azoxymethane (AOM) and dextran sulfate sodium salt (D...
SKLB023 protects against inflammation and apoptosis in sepsis-associated acute kidney injury via the inhibition of toll-like receptor 4 signaling [0.03%]
SKLB023通过抑制 Toll 样受体4信号传导保护内毒素诱导的急性肾损伤中的炎症和细胞凋亡
Hui Li,Qian Ren,Yao Hu et al.
Hui Li et al.
Sepsis-associated acute kidney injury (SA-AKI) is one of common critical illnesses with high morbidity and mortality. At present, effective therapeutic drugs for SA-AKI are remain lacking. SKLB023 is a synthetic small-molecule compound whic...
TLR4 signalling: the key to controlling EV71 replication and inflammatory response [0.03%]
TLR4信号传导在控制EV71复制和炎症反应中的关键作用
Jinfang Hao,Hui Wang,Xiufeng Lu et al.
Jinfang Hao et al.
Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by enterovirus 71 (EV71) that frequently affects children, leading to severe infections in some cases. In general, when infection occurs, the body upregulates inflam...
Saponin Esculeoside A and Aglycon Esculeogenin A from Ripe Tomatoes Inhibit Dendritic Cell Function by Attenuation of Toll-like Receptor 4 Signaling [0.03%]
熟番茄中的皂苷和次甘草素通过抑制 toll 样受体 4 反应削弱树突状细胞功能
Jian-Rong Zhou,Shigenori Kinno,Kenta Kaihara et al.
Jian-Rong Zhou et al.
Dendritic cells (DCs) can initiate immune response through the presenting antigens to naïve T lymphocytes. Esculeoside A (EsA), a spirosolane glycoside, is reported as a major component in the ripe fruit of tomato. Little is known about th...
TAK-242 inhibits glioblastoma invasion, migration, and proneural-mesenchymal transition by inhibiting TLR4 signaling [0.03%]
TAK-242通过抑制TLR4信号传导来抑制胶质母细胞瘤的侵袭、迁移和 proneural-mesenchymal 转化
Zibin Feng,Guangliang Chen,Yunfan Huang et al.
Zibin Feng et al.
Resatorvid (TAK-242), a small-molecule inhibitor of Toll-like receptor 4 (TLR4), has the ability to cross the blood-brain barrier (BBB). In this study, we explored the role of TAK-242 on glioblastoma (GBM) invasion, migration, and proneural...
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