PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1 [0.03%]
与β-连环蛋白-TCF/LEF1复合物结合的聚谷氨酰胺化转录因子EB（TFEB）通过形成复合物调节Wnt靶基因子集的表达
Soyoung Kim,Gahyeon Song,Taebok Lee et al.
Soyoung Kim et al.
Wnt signaling is mainly transduced by β-catenin via regulation of the β-catenin destruction complex containing Axin, APC, and GSK3β. Transcription factor EB (TFEB) is a well-known master regulator of autophagy and lysosomal biogenesis pr...
Effect of kirenol on the interaction between the WNT/β-Catenin and RUNX2/TCF/LEF1 pathways in fracture healing in vivo [0.03%]
苦参碱通过体内活体实验对WNT/β-catenin和RUNX2/TCF/LEF1信号通路互作的影响研究
İbrahim Karaman,Ali Eray Günay,Mükerrem Betül Yerer et al.
İbrahim Karaman et al.
Objective: This study aimed to determine the effects of a natural diterpenoid, kirenol, on fracture healing in vivo in an experimental rat model of femur fracture and investigate its potential mechanism of action via the ...
Pja2 Inhibits Wnt/ β-catenin Signaling by Reducing the Level of TCF/LEF1 [0.03%]
PJA2通过降低TCF/LEF1的水平抑制Wnt/β-catenin信号通路
Yonghee Song,Somyung Lee,Jeong-Rae Kim et al.
Yonghee Song et al.
Ubiquitination of proteins plays an essential role in various cellular processes, including protein degradation, DNA repair, and cell signaling pathways. Previous studies have shown that protein ubiquitination is implicated in regulating pl...
T-cell factor (TCF/LEF1) binding elements (TBEs) of FasL (Fas ligand or CD95 ligand) bind and cluster Fas (CD95) and form complexes with the TCF-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or cell activation [0.03%]
TCF/LEF1结合元件(TBEs)与FasL(Fas配体或CD95配体)结合并聚集Fas(CD95)，并与TCF-4和b-catenin转录因子在体内和体外形成复合物，导致细胞凋亡和(或)活化
Xia Liu,Yuwei Huang,Yuanyuan Zhang et al.
Xia Liu et al.
T-cell factor 4 (TCF4) is an important transcription factor of the Wnt signaling system. β-catenin, an upstream protein of TCF4, accumulates in the cytoplasm, then translocates to the nucleus to activate the β-catenin/T-cell factor/lympho...
Wnt-promoted Isl1 expression through a novel TCF/LEF1 binding site and H3K9 acetylation in early stages of cardiomyocyte differentiation of P19CL6 cells [0.03%]
Wnt通过新的TCF/LEF1结合位点和H3K9乙酰化促进P19CL6细胞心肌细胞分化早期Isl1表达
Huafei Lu,Yanming Li,Yang Wang et al.
Huafei Lu et al.
Islet 1 (ISL1), a marker of second heart field progenitors, plays a crucial role in cardiomyocyte differentiation and proliferation. However, little is known about transcriptional regulating mechanisms on Isl1 gene expression. Recent studie...
TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function [0.03%]
TCF/Lef1介导的脂质代谢调控维持皮肤屏障功能
Dagmar Fehrenschild,Uwe Galli,Bernadette Breiden et al.
Dagmar Fehrenschild et al.
Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well characterized at the molecular level. Using Lef1 (lymphoid enhancer-binding factor 1) dominant-negative mutant mice,...
TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis [0.03%]
TCF/Lef1活性控制小鼠表皮中多种干细胞和祖细胞区室的建立
Monika Petersson,Heike Brylka,Andreas Kraus et al.
Monika Petersson et al.
Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs). It is constantly renewed by stem and progenitor cell populations that have been identified and each compartment featu...
beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes [0.03%]
β-catenin/Tcf/Lef1可在心肌细胞中直接调控伪麻黄碱诱导的细胞肥大和Anf转录
Chen-Guang Zhang,Zhu-Qing Jia,Bin-Hong Li et al.
Chen-Guang Zhang et al.
beta-Catenin/TCF/LEF1 signaling is implicated in cardiac hypertrophy. We demonstrate that knockdown of beta-catenin attenuates phenylephrine (PE)-induced cardiomyocyte hypertrophy and the up-regulation of the fetal gene Anf. We explore the ...
Targeting the WNT/beta-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options [0.03%]
针对实体瘤和血液系统的肿瘤中WNT/β连环蛋白/TCF/LEF1轴的治疗策略：多种潜在治疗选择
Iris Gehrke,Rajesh Kumar Gandhirajan,Karl-Anton Kreuzer
Iris Gehrke
Among aberrantly regulated signalling pathways in cancer the WNT/beta-catenin pathway plays an outstanding role, since it was shown to be critically involved in a wide range of neoplasias. While the underlying mechanisms vary, overexpressio...