SARS-CoV-2 N protein interacts with Nav1.7 to promote pathological pain [0.03%]
SARS-CoV-2 N蛋白与Nav1.7相互作用以促进病理性疼痛
Jin-Kun Liu,Zi-Su Zhou,Shu-Hang Wang et al.
Jin-Kun Liu et al.
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global health crisis, with many patients experiencing not only acute neurological and sensory symptoms but also pe...
SARS-CoV-2 N protein exerts antitumor effects in NSCLC by inducing DNA damage and augmenting chemotherapeutic sensitivity [0.03%]
新型冠状病毒N蛋白通过诱导DNA损伤和增强化疗敏感性在非小细胞肺癌中发挥抗肿瘤作用
Xin Wang,Fang Cao,Di Chen et al.
Xin Wang et al.
Recently, we reported that the SARS-CoV-2 nucleocapsid (N) protein triggers DNA damage by inducing autophagic degradation of RNAi components (Dicer and XPO5) and splicing factors (SRSF3 and hnRNPA3). In this study, we found that the SARS-Co...
SARS-CoV-2 N protein interacts with SLC7A11 to cause ferroptosis in acute lung injury [0.03%]
SARS-CoV-2 N蛋白通过与SLC7A11相互作用引起急性肺损伤铁死亡
Yi Liu,Hui Tang,Pan Xu et al.
Yi Liu et al.
Background: The nucleocapsid protein (N protein) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is elevated in bodily fluids at the onset of infection and has recently been found to have a direct role in ...
Distinct roles of SARS-CoV-2 N protein and NFP in host cell response modulation [0.03%]
SARS-CoV-2的N蛋白和NFP在调节宿主细胞反应中的不同作用
Hsin-Chi Lan,Bo-Yi Hou,Shu-Ting Chang et al.
Hsin-Chi Lan et al.
The SARS-CoV-2 nucleocapsid (N) protein is crucial for viral replication and modulation of host cell responses. Here, we identify and characterize a novel N-fusion protein, designated NFP. NFP is derived from an alternative open reading fra...
Mucosal Immunization with an Influenza Vector Carrying SARS-CoV-2 N Protein Protects Naïve Mice and Prevents Disease Enhancement in Seropositive Th2-Prone Mice [0.03%]
携带SARS-CoV-2 N蛋白的流感载体粘膜免疫保护易感小鼠并防止血清阳性小鼠出现疾病加重现象
Mariia V Sergeeva,Kirill Vasilev,Ekaterina Romanovskaya-Romanko et al.
Mariia V Sergeeva et al.
Background/Objectives: Intranasal vaccination enhances protection against respiratory viruses by providing stimuli to the immune system at the primary site of infection, promoting a balanced and effective response. Influenza vectors with tr...
Affinity Tag-Free Purification of SARS-CoV-2 N Protein and Its Crystal Structure in Complex with ssDNA [0.03%]
不含亲和标签的SARS-CoV-2 N蛋白纯化及其与单链DNA复合物的晶体结构解析
Atanu Maiti,Hiroshi Matsuo
Atanu Maiti
The nucleocapsid (N) protein is one of the four structural proteins in SARS-CoV-2, playing key roles in viral assembly, immune evasion, and stability. One of its primary functions is to protect viral RNA by forming the nucleocapsid. However...
SARS-CoV-2 N protein recruits G3BP to double membrane vesicles to promote translation of viral mRNAs [0.03%]
SARS-CoV-2 N蛋白招募G3BP到双层膜囊泡以促进病毒mRNA的翻译
Siwen Long,Mykhailo Guzyk,Laura Perez Vidakovics et al.
Siwen Long et al.
Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are critical for the formation of stress granules (SGs) through their RNA- and ribosome-binding properties. SARS-CoV-2 nucleocapsid (N) protein exhibits strong binding affinit...
SARS-CoV-2 N protein induces alveolar epithelial apoptosis via NLRP3 pathway in ARDS [0.03%]
SARS-CoV-2 N蛋白通过NLRP3途径诱导ARDS肺泡上皮细胞凋亡
Xiaopei Huang,Wenliang Zhu,Huifeng Zhang et al.
Xiaopei Huang et al.
Acute Respiratory Distress Syndrome (ARDS) is a severe inflammatory condition often resulting from sepsis and viral infections, including (Severe Acute Respiratory Syndrome Coronavirus 2) SARS-CoV-2. This study investigates the molecular me...
Structural basis of the C-terminal domain of SARS-CoV-2 N protein in complex with GMP reveals critical residues for RNA interaction [0.03%]
SARS-CoV-2 N蛋白C末端结构域与GMP复合物的结构基础揭示了RNA结合的关键残基
Xincheng Ni,Yinze Han,Jiao Yu et al.
Xincheng Ni et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein performs multiple functions during the viral life cycle, particularly in binding to the viral genomic RNA to form a helical ribonucleoprotein complex....
Highly Sensitive Electrochemiluminescence Biosensing Method for SARS-CoV-2 N Protein Incorporating the Micelle Probes of Quantum Dots and Dibenzoyl Peroxide Using the Screen-Printed Carbon Electrode Modified with a Carboxyl-Functionalized Graphene [0.03%]
基于羧基功能化石墨烯和量子点-二苯甲酰过氧化物胶束探针的屏幕印刷碳电极高效检测SARS-CoV-2 N蛋白电化学发光生物传感方法
Pengxue Wu,Liang Zhang,Guilan Zhang et al.
Pengxue Wu et al.
Obtaining stable electrochemiluminescence (ECL) emissions from a hydrophobic luminophore in aqueous solutions and designing a method without the use of an exogenous coreactant are promising for ECL biosensing. Here, a highly sensitive signa...
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