Single-cell and bulk RNA analysis identifies EMT-associated CAF signatures and prognostic model in lung adenocarcinoma [0.03%]
单细胞和批量RNA分析鉴定肺癌腺癌相关EMT表型的CAF特征及预后模型
He An,Ping An
He An
Background: Cancer-associated fibroblasts (CAFs) have gained increasing attention for their role in lung adenocarcinoma (LUAD), particularly in epithelial-mesenchymal transition (EMT), which may play a key role in tumor m...
RNA Analysis Enables Resolution and Reclassification of Reportedly Benign Synonymous Variants [0.03%]
基于RNA分析对据报道为良性同义变异的再分类及重新定义
Adina Fuchs,Inbar Kobal,Dov Popper et al.
Adina Fuchs et al.
Synonymous variants can significantly impact protein levels and function, particularly through alterations in RNA processing. Consequently, variant classification must consider the broader impact on RNA splicing. We present three cases wher...
Multiplex-RNA-analysis for detection and identification of forensically relevant organ tissues [0.03%]
用于检出和鉴定法医重要器官组织的多功能RNA分析方法研究
Kathrin Broderius,Annica Gosch,Cornelius Courts
Kathrin Broderius
In forensic investigations, identifying the bodily origin of components in biological trace material can be essential for the evidence-based reconstruction of criminal events. Complementing standard forensic DNA analyses, specific RNA marke...
CellBouncer, A Unified Toolkit for Single-Cell Demultiplexing and Ambient RNA Analysis, Reveals Hominid Mitochondrial Incompatibilities [0.03%]
CellBouncer的发现：单细胞解复用和环境RNA分析的统一工具揭示了灵长类动物线粒体的不相容性
Nathan K Schaefer,Bryan J Pavlovic,Alex A Pollen
Nathan K Schaefer
Pooled processing, in which cells from multiple sources are cultured or captured together, is an increasingly popular strategy for droplet-based single cell sequencing studies. This design allows efficient scaling of experiments, isolation ...
Elucidating Molecule-Crosstalk of Neutrophil Extracellular Traps Between Cardiovascular Disease and Psoriasis: Insights Into Mendelian Randomization, Single-Cell RNA Analysis, Shared Targets and the Role of Resveratrol [0.03%]
阐明心血管疾病和银屑病之间的中性粒细胞外陷阱分子串扰：孟德尔随机化、单细胞RNA分析、共享靶点以及白藜芦醇的作用中的见解
Xiaojun Jin,Yun Zhang,Gaofeng Qin et al.
Xiaojun Jin et al.
Background: Left ventricular hypertrophy (LVH) associated with hypertension and psoriasis (PSO) are linked by poor prognosis. Neutrophil extracellular traps (NETs) are implicated in both conditions, but the mechanisms rem...
Expression profile and N6-methyadenosine modification of circular RNA analysis in MAFLD [0.03%]
MAFLD中环状RNA的表达谱和N6-甲基腺苷修饰分析
Mengyao Zheng,Dongyun Cun,Haiyu He et al.
Mengyao Zheng et al.
Background: To analyze the expression patterns of circRNAs in metabolic associated fatty liver disease (MAFLD) and the regulation of m6A methylation on those circRNAs. ...
Epileptic spasms and RNA analysis in a new case of Kabuki syndrome type 2 [0.03%]
Kabuki综合征2型新病例的癫痫痉挛和RNA分析
Flavia Privitera,Camilla Meossi,Filippo Maria Santorelli et al.
Flavia Privitera et al.
Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia [0.03%]
基于机器学习的批量RNA分析揭示了13种细胞死亡模式的预后特征以及在急性髓性白血病中SMAD3的潜在治疗靶点
Xiebing Bao,Yao Chen,Jie Chang et al.
Xiebing Bao et al.
Background: Dysregulation or abnormality of the programmed cell death (PCD) pathway is closely related to the occurrence and development of many tumors, including acute myeloid leukemia (AML). Studying the abnormal charac...
Circulating Micro-RNAs in Patients with Hypophosphatasia Results of the first micro-RNA analysis in HPP [0.03%]
低磷酸酶症患者循环中的微小核糖核酸（micro-RNA）水平：首次针对HPP的micro-RNA分析结果
Judith Haschka,Zora Messner,Julia Feurstein et al.
Judith Haschka et al.
Introduction: Adult hypophosphatasia (HPP) patients present with diffuse heterogenous symptoms often mimicking rheumatological diseases or osteoporosis and therefore accompanied by delayed diagnosis. The aim of this study...
Integrative Transcriptomic and Small RNA Analysis Uncovers Key Genes for Cold Resistance in Rice [0.03%]
整合转录组和小RNA分析揭示水稻抗寒关键基因
Fan Luo,Mengmeng Yin,Jianping Zhou et al.
Fan Luo et al.
Background/objectives: Cold stress is the main environmental factor that affects the growth and development of rice, leading to a decrease in its yield and quality. However, the molecular mechanism of rice's low-temperatu...
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