Podocyte A20/TNFAIP3 Controls Glomerulonephritis Severity via the Regulation of Inflammatory Responses and Effects on the Cytoskeleton [0.03%]
足细胞A20/TNFAIP3通过调控炎症反应及对细胞骨架的作用来控制肾小球肾炎的严重程度
Paulina Köhler,Andrea Ribeiro,Mohsen Honarpisheh et al.
Paulina Köhler et al.
Ultrastructural analysis of A20 podocyte-knockout mouse glomeruli revealed hypocellularity of the glomerular tuft, expansion of the extracellular matrix, podocytopenia associated with foot process effacement, karyopyknosis, micronuclei, and podocyte detachment.
A human stem cell-derived model reveals pathologic extracellular matrix remodeling in diabetic podocyte injury [0.03%]
人源干细胞模型揭示糖尿病系膜细胞病理性基质重塑机制
Yasmin Roye,Carmen Miller,Titilola D Kalejaiye et al.
Yasmin Roye et al.
The model recapitulated hallmarks of podocytopathy that precede proteinuria including retraction of foot processes and podocytopenia (detachment from the extracellular matrix (ECM)). Moreover, hyperglycemia-induced injury to podocytes exacerbated remodeling of the ECM....This collagen (IV) imbalance coincided with dysregulation of lineage-specific proteins, structural abnormalities of the ECM, and podocytopenia - a mechanism not shared with endothelium and is distinct from drug-induced injury.
Assessment of podocyte detachment as a pivotal step in the development of focal segmental glomerulosclerosis [0.03%]
评估足细胞脱落在局灶节段性肾小球硬化发病机制中的关键作用
Ikbal Ahmed Abdo Elkholy,Wagdi Elkashef,Fatma El-Husseini Mostafa et al.
Ikbal Ahmed Abdo Elkholy et al.
Pathological assessment of podocytopenia plays a crucial role in diagnosing underlying kidney diseases.
Influence of Podocyte Injury on the Development of Class IV Lupus Nephritis [0.03%]
足细胞损伤对狼疮性肾炎IV型发病的影响
Cyntia Camilo Franco Borges Zago,Bruna de Freitas Oliveira,Giovanna Uehara et al.
Cyntia Camilo Franco Borges Zago et al.
Podocyturia with consequent podocytopenia has been described in some nephropathies such as LN, highlighting the importance of studying podocyte injuries in this condition.
Urolithin A Ameliorates the TGF Beta-Dependent Impairment of Podocytes Exposed to High Glucose [0.03%]
尿石素A改善高糖暴露的 podocyte 的TGFβ依赖性损伤
Barbara Lewko,Milena Wodzińska,Agnieszka Daca et al.
Barbara Lewko et al.
Our results indicate that in podocytes cultured in conditions mimicking the diabetic milieu, UA inhibits and reverses changes underlying podocytopenia in diabetic kidneys.
Podocyte-Specific Expression of the Stress Response Protein REDD1 is Necessary for Diabetes-induced Podocytopenia [0.03%]
糖尿病引起的足细胞减少症需要应激反应蛋白REDD1在足细胞中的特异性表达
Siddharth Sunilkumar,Esma I Yerlikaya,Allyson L Toro et al.
Siddharth Sunilkumar et al.
Notably, podocyte-specific REDD1 deletion protected against podocytopenia and preserved glomerular basement membrane and foot process architecture in diabetic mice.
Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis [0.03%]
二甲双胍治疗 focal segmental glomerulosclerosis 的临床 II 期试验的设计和理由：一种评估AMP活化蛋白激酶的双盲，随机，带有对照组的试验方法
Gabriel C Barsotti,Randy Luciano,Ashwani Kumar et al.
Gabriel C Barsotti et al.
Identifying mechanisms capable of preventing podocytopenia during injury could transform FSGS to an "MCD-like" state. Preclinical data have reported conversion of an MCD-like injury to one with podocytopenia and FSGS by inhibition of AMP-kinase (AMPK) in podocytes....Conversely, in FSGS, AMPK-activation using metformin (MF) mitigated podocytopenia and azotemia. Observational studies also support beneficial effects of MF on proteinuria and chronic kidney disease (CKD) outcomes in diabetes.
Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury [0.03%]
podocyte分泌的可溶性RARRES1通过直接损伤系膜细胞和近端小管促进肾脏疾病进展
Ye Feng,Zeguo Sun,Jia Fu et al.
Ye Feng et al.
RARRES1 promotes podocytopenia and glomerulosclerosis via p53-mediated podocyte apoptosis.
Prothrombin Knockdown Protects Podocytes and Reduces Proteinuria in Glomerular Disease [0.03%]
凝血酶原敲除保护足细胞并减少蛋白尿在肾小球疾病中的作用
Amanda P Waller,Katelyn J Wolfgang,Iva Pruner et al.
Amanda P Waller et al.
Podocytopathy and podocytopenia were determined and proteinuria, and plasma albumin were measured. LoPT significantly reduced prothrombin colocalization to podocytes, podocytopathy, and proteinuria with improved plasma albumin.
[Protective effect and mechanism of electroacupuncture of "Biao-Ben" acupoints combination for mitochondrial dysfunction in diabetic nephropathy rats] [0.03%]
“表本”电针通过改善糖尿病肾病大鼠足细胞线粒体功能抑制其 podocytopenia 的作用及机制研究
Jia Chen,Bei Chen,Feng-Xia Liang et al.
Jia Chen et al.
Objective: To study the protective effect of electroacupuncture (EA) at "Biao"-acupoints, "Fenglong"(ST40) and "Zhongwan"(CV12), used for treating symptoms of the disease, and "Ben"-acupoints, "Zusanli"(ST36) and "Guanyua...
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