Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents [0.03%]
早期生活不确定性对青少年海马区和杏仁核 novelty反应的性别差异影响
Elysia Poggi Davis,Bianca T Leonard,Robert J Jirsaraie et al.
Elysia Poggi Davis et al.
Background: Unpredictable childhood experiences are an understudied form of early-life adversity that impact neurodevelopment. The neurobiological processes by which exposure to early-life unpredictability impact developm...
Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs [0.03%]
采用两种遗传设计研究易怒作为潜在原因的风险途径导致抑郁的原因
Amy Shakeshaft,Olakunle Oginni,Joanna Martin et al.
Amy Shakeshaft et al.
Background: Major depressive disorder (MDD) is heterogeneous, with diverse risk pathways leading to illness. Identifying causal routes to depression helps prioritize targets for early intervention and prevention strategie...
Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study [0.03%]
全面分析平台以了解、治疗和消除肌萎缩侧索硬化症（CAPTUREALS）：一项加拿大多中心、多模式、纵向观察性研究的方案
Natalie Saunders,Claire Magnussen,HyungMo Kang et al.
Natalie Saunders et al.
Data and samples are stored in a biobank operating under an open science governance framework. An inclusive and transparent participant engagement strategy was designed and implemented throughout all stages of CAPTURE ALS. Four sites are operating in the consortium with a fifth being onboarded.
Observational Study
PloS one. 2025 Dec 4;20(12):e0332430. DOI:10.1371/journal.pone.0332430 2025
Outcomes After Initial Noninterventional Management of Clinical Stage cT1b Renal Masses [0.03%]
临床一期T1b肾占位性疾病初始非干预管理后的转归状况
Banna Hussain,Jack Considine,Yuzhi Wang et al.
Banna Hussain et al.
Background and objective: Localized renal masses 4.1-7.0 cm in size (cT1bRMs) are typically treated with partial or radical nephrectomy. Utilization and results of initial nonsurgical approaches for cT1bRMs are unclear. O...
Clinical Criteria to Guide Antineuronal Antibody Testing for People With Early and Persistent Psychosis Attending Mental Health Services [0.03%]
指导精神卫生服务机构中早期且持续精神病患者进行抗神经元抗体检测的临床标准
Gemma McKeon,Andrea Baker,Stefan Blum et al.
Gemma McKeon et al.
Background: Early detection of autoimmune psychosis (AP) mediated by antineuronal antibodies (Abs) is critical for achieving optimal clinical outcomes. However, evidence remains limited regarding who should be tested and ...
A Randomised Clinical Trial Comparing Two Biopsy Templates and Follow-up Schedules for Men on Active Surveillance for Low-risk Prostate Cancer: SAMS [0.03%]
低危前列腺癌积极监测患者的两种活检方案和随访方案的随机临床试验：SAMS研究
David Robinson,Jovana Maljkovic,Anna Genell et al.
David Robinson et al.
Background and objective: Neither the number nor location of biopsy cores or follow-up schedules for active surveillance of prostate cancer are based on evidence from randomised trials. We therefore initiated a study that...
Oncological Results After Accidental Tumor Incision During Partial Nephrectomy [0.03%]
部分肾切除术中意外切开肿瘤的 oncological结果
Markus Varpela,Sara Tornberg,Harry Nisen et al.
Markus Varpela et al.
Background and objective: Incising or breaking a tumor during surgery for renal cell carcinoma (RCC) is considered an adverse event. The aim of our study was to examine oncological outcomes for patients with accidental tu...
Prospective Evaluation of Blood-based and Microbiological Early Indicators of In-hospital Infectious Complications After Open Cystectomy [0.03%]
开腹膀胱切除术后住院感染并发症的血液和微生物早期指标的前瞻性评价
Benedikt Ebner,Judith Hirsch,Annkathrin Holz et al.
Benedikt Ebner et al.
Background and objective: In-hospital infectious complications after cystectomy are understudied, with no reliable predictive tools. The aim of our study was to (1) comprehensively and prospectively evaluate these complic...
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