Effects of mitoquinone and caffeic acid on spermatological parameters and OGG1/ROMO1 gene expression of post-thawed ram semen [0.03%]
肉桂酸和辅酶Q10对冻融后公羊精液生精参数及OGG1/ROMO1基因表达的影响
Mehmet Melih Yılmaz,Sena Ardicli,Tugaycan Cimen et al.
Mehmet Melih Yılmaz et al.
The aim of this study was to determine the freezability of ram semen with extenders containing mitoquinone or caffeic acid. Collected ram semen samples were pooled and divided into seven equal aliquots. Each aliquot was diluted with Tris-ba...
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue [0.03%]
CD4+组织驻留记忆Th17细胞是银屑病关节炎滑膜组织中IL-17A的主要来源
Feng Liu,Hui Shi,Jason D Turner et al.
Feng Liu et al.
Objectives: Interleukin (IL)-17A is a key driver of spondyloarthritis (SpA) joint pathology. We aimed to identify its cellular source in synovial tissue from patients with 2 forms of SpA, namely axial SpA (AxSpA) and psor...
RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA [0.03%]
RBM39通过稳定OGG1 mRNA促进碱基切除修复以促进肝细胞癌进展
Hongda An,Anliang Xia,Siyuan Liu et al.
Hongda An et al.
Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics. RNA-binding motif protein 39 (RBM39) modulates the alternative splicing of numerous genes involved in cancer occurrence and progression. However, w...
Organocatalytic switches of DNA glycosylase OGG1 catalyze a highly efficient AP-lyase function [0.03%]
有机催化开关OGG1 DNA糖基化酶切换高效脱氨酶功能
Mario Kehler,Kaixin Zhou,Aurino M Kemas et al.
Mario Kehler et al.
8-oxoGuanine DNA glycosylase 1 (OGG1) is the first known target of organocatalytic switches (ORCAs), which rewrite the biochemical function of the enzyme through redirection of its preferred substrate from 8-oxoG to AP sites. Previously, di...
Intraoperative Pyloric Botulinum Toxin Injection for Post Total Pancreatectomy with Islet Autotransplantation Gastroparesis Improvement in Children [0.03%]
博利毒素注射治疗儿童全胰腺切除并自体胰岛移植术后胃轻瘫病症的术中应用研究
Juan P Gurria,Bhargava Mullapudi,Colleen M O Lowe et al.
Juan P Gurria et al.
Background: Acute Recurrent Pancreatitis (ARP) and Chronic Pancreatitis (CP) may cause abdominal pain, malnutrition, opioid dependency, and impairment in quality of life. Total Pancreatectomy with Islet Autotransplantatio...
Oxidative Stress Regulates CDH3 Expression in Lung Cancer Cells via OGG1-Mediated SP1 Binding [0.03%]
OGG1介导的SP1结合通过氧化应激调节肺癌细胞中的CDH3表达
Ying Ma,Jiarong Guo,Shichu Xu et al.
Ying Ma et al.
Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, plays a crucial role in tumor development. Tumor cells often experience elevated oxidative stress due to rapid prolifer...
Inhibition by 4-(4-Bromo-2-oxo-3 H-benzimidazol-1-yl)- N-(4-iodophenyl)piperidine-1-carboxamide (TH5487) of the Activity of Human 8-Oxoguanine DNA Glycosylase-1 (OGG1) for the Excision of 2,6-Diamino-4-hydroxy-5-formamidopyrimidine, 4,6-Diamino-5-formamidopyrimidine, and 8-Oxoguanine from Oxidatively [0.03%]
化合物TH5487抑制人源8-氧鸟嘌呤DNA脱氨酶(OGG1)切除2,6-二氨基-4-羟基-5-甲酰胺基嘧啶、4,6-二氨基-5-甲酰胺基嘧啶和8-氧化鸟嘌呤的作用
Pawel Jaruga,Melis Kant,Michael M Luzadder et al.
Pawel Jaruga et al.
DNA glycosylases of the base excision repair pathway have become clinically validated drug targets for the treatment of several diseases. Human OGG1 (hOGG1) is specific for the removal of the highly mutagenic 8-oxoguanine (8-oxo-Gua) and 2,...
Oxidative stress induced liver damage in dengue is exacerbated in those with obesity [0.03%]
登革热中肥胖导致的氧化应激引起的肝损伤加重
Heshan Kuruppu,Maneshka Karunananda,Chandima Jeewandara et al.
Heshan Kuruppu et al.
Background: Obesity and diabetes are risk factors for severe dengue. As there are limited data on the association of obesity with liver dysfunction and oxidative stress in patients with acute dengue, we investigated liver...
NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence Regulation [0.03%]
NLRP10切割氧化DNA被OGG1抑制剂抑制：在DNA损伤处理和衰老调节中一个新识别的作用
Julia Elise Cabral,Sophia Lin,Haitian Zhou et al.
Julia Elise Cabral et al.
Mitochondrial DNA (mtDNA) release into the cytosol is a critical event in innate immune activation, often acting as a damage-associated molecular pattern (DAMP) that triggers inflammasome assembly. Here, we demonstrate that NLRP3 plays a di...
Modulation of OGG1 enzymatic activities by small molecules, promising tools and current challenges [0.03%]
小分子对OGG1酶活性的调节，有前景的工具和当前挑战
Xavier Renaudin,Anna Campalans
Xavier Renaudin
Oxidative DNA damage, resulting from endogenous cellular processes and external sources plays a significant role in mutagenesis, cancer progression, and the pathogenesis of neurological disorders. Base Excision Repair (BER) is involved in t...
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