Effects of mesenchymal stem cell exosomes on trabecular meshwork cells via the NRF2 pathway [0.03%]
外源性间充质干细胞通过NRF2通路调控小梁细胞抗氧化能力及增殖作用研究
Li Xu,Peng Xu,Na Song et al.
Li Xu et al.
Objectives: Increased intraocular pressure (IOP) is a significant risk factor for primary open-angle glaucoma (POAG). Physiologically, the trabecular meshwork (TM) controls IOP and the secretion of aqueous humor. A change...
Liquid-Liquid Phase Separation of AR Orchestrated by Melatonin Sensitizes Prostate Cancer to Ferroptosis Via MCM5/NRF2 Axis Collapse [0.03%]
褪黑素诱导的AR液-液相分离通过破坏MCM5/NRF2轴使前列腺癌对铁死亡敏感化
Xianyanling Yi,Zeyu Han,Yaxiong Tang et al.
Xianyanling Yi et al.
The treatment of prostate cancer (PCa) remains challenging, and while melatonin (MEL) has demonstrated therapeutic potential, its precise mechanisms require further elucidation. Through integrated in vitro, in vivo, and bioinformatics analy...
Angelicin attenuates sepsis-associated acute liver injury via p38 MAPK inhibition and NF-κB-mediated Nrf2/Keap1 activation to suppress inflammation and oxidative stress [0.03%]
通过p38丝裂原活化蛋白激酶抑制和NF-κB介导的Nrf2 / Keap1激活来减轻炎症和氧化应激以缓解天仙子苷素引起的脓毒症相关急性肝损伤
Enzhuang Pan,Huilin Sun,Shasha Zhang et al.
Enzhuang Pan et al.
Sepsis-associated acute liver injury (SALI) is a frequent and clinically severe complication of sepsis, in which inflammatory responses and oxidative stress are involved. Angelicin (ANG), one of the main active components in the traditional...
Sesaminol Inhibits Adipogenesis by Suppressing Mitotic Clonal Expansion and Activating the Nrf2-ARE Pathway [0.03%]
sesaminol通过抑制有丝分裂克隆扩增和激活Nrf2-ARE通路来抑制脂肪细胞生成
Saki Nakamatsu,Miki Nakata,Toshio Norikura et al.
Saki Nakamatsu et al.
Background: As a key contributor to metabolic disorders, obesity is recognized as a critical global health challenge. Adipocyte differentiation depends on the mitotic clonal expansion (MCE) phase, which is controlled by o...
Fatih Koçtürk,Firdevs Emekli,Kadir Eği et al.
Fatih Koçtürk et al.
Background and Objectives: Migraine is the most common primary headache disorder worldwide, negatively affecting quality of life and limiting the functionality of individuals. Although its pathogenesis is not fully understood, it is known t...
Beyond Antioxidants: The Emerging Role of Nrf2 Activation in Amyotrophic Lateral Sclerosis (ALS) [0.03%]
超越抗氧化剂：Nrf2激活在肌萎缩侧索硬化症（ALS）中作用的新兴角色
Minoo Sharbafshaaer,Roberta Pepe,Rosaria Notariale et al.
Minoo Sharbafshaaer et al.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder involving the progressive degeneration of upper and lower motor neurons. While oxidative stress, RNA-binding protein (RBP) pathology, mitochondrial dysfunction, and glial-n...
The Role of miR-144/Nrf2 Pathway in Muscle Oxidative Stress Induced by Oxidized Fish Oil in Megalobrama amblycephala, with an Emphasis on Protein Oxidation [0.03%]
miR-144/Nrf2信号通路在翘嘴鱼(Megalobrama amblycephala)氧化型鱼油诱导的肌肉氧化应激中的作用及对蛋白质氧化的影响
Jie Yang,Xiaochuan Zheng,Qunlan Zhou et al.
Jie Yang et al.
This study investigated the role of miR-144 in mitigating oxidized fish oil (OFO)-induced muscle oxidative stress and quality deterioration in Megalobrama amblycephala. The feeding trial was conducted for 5 weeks, and four experimental diet...
Maria-Armineh Tossounian,Alexander Zhyvoloup,Rakesh Chatterjee et al.
Maria-Armineh Tossounian et al.
BACH1 (BTB And CNC Homology 1) and NRF2 (Nuclear Factor Erythroid 2-related Factor 2) are transcription factors that regulate antioxidant and iron metabolism genes by competing for binding to cis-regulatory Maf-binding elements (CsMBEs) as ...
Melatonin-Mediated Nrf2 Activation as a Potential Therapeutic Strategy in Mutation-Driven Neurodegenerative Diseases [0.03%]
褪黑素介导的Nrf2激活作为突变引起的神经退行性疾病的潜在治疗策略
Lucía Íñigo-Catalina,María Ortiz-Cabello,Elisa Navarro et al.
Lucía Íñigo-Catalina et al.
Neurodegeneration is intrinsically linked to aging through processes such as oxidative stress, mitochondrial dysfunction, and chronic inflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) emerges as a central transcription factor...
Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway [0.03%]
maresin-1通过Nrf2/HO-1/GPx4信号通路抑制铁死亡从而缓解脓毒症诱导的急性肾损伤
Lili Tang,Dongrui He,Pengyu Wan et al.
Lili Tang et al.
Purpose: Sepsis-induced acute kidney injury (S-AKI) is a severe complication of sepsis. This study aimed to explore the protective effects of Maresin-1 (MaR-1) on S-AKI and elucidate its potential molecular mechanisms, fo...
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