The NLRP3 inflammasome and its role in acute myeloid leukemia onset and development [0.03%]
NLRP3炎性小体在急性髓系白血病发生发展中的作用研究
Brunno Gilberto Santos de Macedo,Manuela Albuquerque de Melo,Diego Antonio Pereira-Martins et al.
Brunno Gilberto Santos de Macedo et al.
The tumor microenvironment plays an important role in cancer onset and progression. Its significance has been increasingly addressed in myeloid neoplasms. Such a shift marks a departure from the usual tumor-centered approach to a more compr...
mTOR Modulates NLRP3 Inflammasome Activation via Nuclear Translocation and STAT1 Inhibition [0.03%]
mTOR通过核转位和抑制STAT1调节NLRP3炎性小体活化
Alvaro González-Dominguez,Shuling Zhang,Daniel Boy-Ruiz et al.
Alvaro González-Dominguez et al.
The NLRP3 inflammasome has emerged as an unexpected sensor of metabolic danger and stress. Their enhanced activation has been implicated in the development of major diseases such as gout, Type 2 diabetes, obesity, cancer, and neurodegenerat...
HIV-1 Tat mediates microglial NLRP3 inflammasome activation and neurotoxicity by inducing cytosolic mtDNA stress [0.03%]
HIV-1 Tat通过诱导细胞质线粒体DNA应激介导小胶质细胞NLRP3炎性小体活化和神经毒性
Xiaotian Yang,Pengchun Han,Mengyu Li et al.
Xiaotian Yang et al.
Tat, a regulatory protein of human immunodeficiency virus (HIV)-1, is a potent viral neurotoxin which can activate the NLRP3 inflammasome in microglia and contribute to neurotoxicity. Here, we found that HIV Tat induces mitochondrial dysfun...
Demethyleneberberine ameliorates pulmonary fibrosis by inhibiting the NLRP3 inflammasome and the epithelial-mesenchymal transition [0.03%]
demethyleneberberine通过抑制NLRP3炎性小体和上皮间质转化来改善肺纤维化
Xinye Wang,Xinyu Wu,Liqin Zhou et al.
Xinye Wang et al.
Background and aims: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by inflammation and fibrosis. Demethyleneberberine (DMB), a natural compound derived from traditional Chinese m...
Ginsenoside Rg1 alleviates PCPA-induced insomnia by inhibiting NLRP3 inflammasome activation and pyroptosis through the Nrf2/HO-1 pathway in mice [0.03%]
Ginsenoside Rg1通过Nrf2/HO-1途径抑制NLRP3炎性小体活化和细胞焦亡缓解PCPA诱导的小鼠失眠症
Jingyi Li,Xiufeng Wang,Yu Zhang et al.
Jingyi Li et al.
Objectives: This study aims to investigate the neuroprotective effects of Ginsenoside Rg1 in alleviating P-chlorophenylalanine (PCPA)-induced insomnia and explore its underlying mechanisms involving the inhibition of NOD-...
Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome [0.03%]
刺槐素通过NLRP3炎性小体抑制炎症和破骨细胞生成作用
Wei Zhang,Xiangbing Wu,Wenming Li et al.
Wei Zhang et al.
Pro-inflammatory cytokines such as TNF, IL-1, and IL-6 trigger aberrant osteoclastogenesis and result in massive bone loss. During RANKL-induced osteoclastogenesis, pyroptosis of macrophages/preosteoclasts acts as a pivotal mechanism for IL...
LncRNA MIR503HG regulates NETs-mediated NLRP3 inflammasome activation and NSCLC metastasis by enhancing the ubiquitination of C/EBPβ [0.03%]
长链非编码RNA MIR503HG通过增强C/EBPβ的泛素化调节NETs介导的NLRP3炎性小体活化和NSCLC转移
Xin Ye,Chen Fang,Weiwei Hong et al.
Xin Ye et al.
Background: Neutrophil extracellular traps (NETs) are pivotal in the metastasis of non-small cell lung cancer (NSCLC). Our previous research demonstrated that NETs facilitate NSCLC metastasis by triggering the stimulation...
Cross-talk between NLRP3 and AIM2 inflammasomes in macrophage activation by LPS and titanium ions [0.03%]
LPS和钛离子通过NLRP3和AIM2炎症小体的串扰活化巨噬细胞
Ana Belén Carrillo-Gálvez,José Antonio Guerra-Valverde,Miguel Padial-Molina et al.
Ana Belén Carrillo-Gálvez et al.
Background: Periodontitis and peri-implantitis are chronic inflammatory diseases that contribute to tissue destruction and bone loss. Periodontitis is triggered by pathogenic bacteria, while peri-implantitis also involves...
Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation [0.03%]
纳米管地形通过减少微管谷氨酰化来抑制NLRP3炎性小体的活化
Dingqiang Mo,Wenxue Zhang,Hengji Jia et al.
Dingqiang Mo et al.
The topography of the implant surface is critical in modulating the inflammatory immune environment and serves as a crucial determinant for the success of osseointegration. Immune cells, particularly macrophages, are capable of detecting me...
Caspase-8-driven NLRP3 inflammasome activation exacerbates bronchopulmonary dysplasia by increasing the apoptosis and pyroptosis crosstalk of alveolar epithelial cells [0.03%]
半胱天冬酶-8驱动的NLRP3炎性小体激活通过增加肺泡上皮细胞凋亡与焦亡交互加重支气管肺发育不良
Dabin Huang,Debo Xu,Chuming You et al.
Dabin Huang et al.
Background: The programmed cell death (PCD) of alveolar epithelial cells, which is mediated by inflammation and oxidative stress, plays an important role in the development of bronchopulmonary dysplasia (BPD). Caspase-8 i...
耗时 0.23586 秒，为您在
48206918
条记录里面共找到 6279 篇文章 [XML]