主题词1:Microbial+Production
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Two routes for tyrosol production by metabolic engineering of Corynebacterium glutamicum [0.03%] 丙酮丁醇梭菌中两条L-茶氨酸生物合成途径的构建及调控优化
Nora Junker,Sara-Sophie Poethe,Volker F Wendisch Nora Junker
Tyrosol can be found in olive oil, but despite its natural biosynthesis in plants, low extraction efficiencies render microbial production a more viable alternative.
A comprehensive review on microbial production and significant applications of multifunctional biomolecules: biosurfactants [0.03%] 微生物多功能生物分子(生物表面活性剂)的生产及其重要应用的综述
Nisha Sharma,Yogesh K Ahlawat,Arti Jamwal Sharma et al. Nisha Sharma et al.
Microorganisms are very well known potential sources of many novel metabolites and biosurfactants (green molecules). Biosurfactants are biobased molecules which are synthesized by bacteria, yeasts, fungi and actinomycetes. These biomolecule...
Hydroxybenzoic acids: Microbial metabolism, pathway engineering and products [0.03%] 羟基苯甲酸:微生物代谢、途径工程和产品
Ingrida Kutraite,Ernesta Augustiniene,Naglis Malys Ingrida Kutraite
Here, the existing challenges are highlighted and the potential strategies for improved microbial production of HBAs are identified. Key aspects of HBAs metabolism and complexity of the factors related to bacterial strain selection, titer, and bioprocess strategy are examined.
Q112.12024 Review Biotechnology advances. 2025 Mar 26:108571. DOI:10.1016/j.biotechadv.2025.108571 2025
Microbial Production of Hyaluronic Acid: The Current Advances, Engineering Strategies and Trends [0.03%] 透明质酸的微生物生产:最新进展,工程策略和趋势
Ehab Marwan-Abdelbaset,Mohamed Samy-Kamal,Dan Tan et al. Ehab Marwan-Abdelbaset et al.
This review focuses on the microbial production of HA using engineered strains, encompassing producer organisms, metabolic engineering strategies, industrial-scale production, and key factors influencing molecular weight.
CRISPR/Cas9-based iterative multi-copy integration for improved metabolite yields in Saccharomyces cerevisiae [0.03%] 基于CRISPR/Cas9的多次迭代多拷贝整合以提高酿酒酵母中的代谢产物的产量
Ximei Chen,Chenyang Li,Xin Qiu et al. Ximei Chen et al.
By streamlining the integration process, utilizing growth-based selection, and minimizing screening demands in both equipment and labor, the IMIGE system could provide an efficient and scalable platform for high-throughput strain engineering, facilitating enhanced microbial production of a wide range
Dual Antibiotic-Free Plasmid Systems Enable High-Efficiency l-Fucose Biosynthesis [0.03%] 双质粒系统实现高效l-岩藻糖生物合成
Jiawei Meng,Yingying Zhu,Zhen Lu et al. Jiawei Meng et al.
l-Fucose, a functional monosaccharide with significant commercial potential in the pharmaceutical, nutraceutical, and cosmetic industries, faces challenges in microbial production due to antibiotic-dependent plasmid maintenance systems.
Robustness of the Cupriavidus necator-Catalyzed Production of α-Humulene [0.03%] Cupriavidus necator催化生产α-胡薄荷醇的稳健性
Lucas Becker,Emely Dietz,Dirk Holtmann Lucas Becker
The increasing global demand for natural substances such as the sesquiterpene α-humulene makes optimizing microbial production essential. A production process using the versatile host Cupriavidus necator has been recently improved by adjusting the minimal media and process parameters.
Low-biomass pyruvate production with engineered Vibrio natriegens is accompanied by parapyruvate formation [0.03%] 工程改造的Vibrio natriegens伴随旁丙酮酸生成低生物量丙酮酸的过程
Maurice Hädrich,Clarissa Scheuchenegger,Sören-Tobias Vital et al. Maurice Hädrich et al.
Background: Pyruvate is a precursor for various compounds in the chemical, drug, and food industries and is therefore an attractive target molecule for microbial production processes.
Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact [0.03%] 生物学与工程学的交汇:微生物营养药物的规模化生产以连接营养、治疗和全球影响
Ahmed M Elazzazy,Mohammed N Baeshen,Khalid M Alasmi et al. Ahmed M Elazzazy et al.
By harnessing their natural metabolic capabilities, microorganisms efficiently synthesize these bioactive compounds, making microbial production a sustainable and effective approach for nutraceutical development....With a focus on sustainability and precision, microbial production is positioned as a game-changer in the nutraceutical industry, offering eco-friendly and scalable solutions to meet global health needs.
Engineering Yarrowia lipolytica for Enhanced Gastrodin Production via High-Throughput Screening and Transcriptomics-Guided Optimization [0.03%] 通过高通量筛选和转录组学指导优化工程改造耶罗瓦脂酵母以增强瓜蒌多糖产量
Mengchen Hu,Yijin He,Yifan Ma et al. Mengchen Hu et al.
This study seeks to enhance microbial production of gastrodin through high-throughput screening (HTS) and transcriptomics-guided optimization. Initially, atmospheric pressure and room temperature plasma (ARTP)-mediated mutagenesis were employed to develop a library of mutant strains.
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