Ella A Eklund,Mathilda Orgard,Delice Wallin et al. Ella A Eklund et al.

Introduction: Stage III non-small cell lung cancer (NSCLC) is a heterogeneous group and identification of subgroups with differential treatment responses is crucial. Addition of durvalumab to concurrent chemoradiotherapy ...

Nomin Bold,Khurelsukh Buyanbat,Ariya Enkhtuya et al. Nomin Bold et al.

Background: Mongolia has the highest incidence of liver cancer worldwide, largely driven by a high prevalence of hepatitis virus infections. Mutations in oncogenes and tumor suppressor genes provide valuable insights into...

Rawan Abudalo,Abdelrahim Alqudah,Roaa Alnajjar et al. Rawan Abudalo et al.

Colorectal cancer (CRC) is increasingly prevalent in Jordan and poses a significant public health challenge. The presence of Kirsten rat sarcoma viral oncogene homolog (KRAS), neuroblastoma RAS viral oncogene homolog (NRAS) and v-Raf Murine...

Anita Emami,Pouya Mahdavi Sharif,Nima Rezaei Anita Emami

Introduction: Despite decreasing trends in incidence, colorectal cancer (CRC) is still a major contributor to malignancy-related morbidities and mortalities. Groundbreaking advances in immunotherapies and targeted therapi...

Chendi Li,Mohammed Usman Syed,Anahita Nimbalkar et al. Chendi Li et al.

The efficacy of molecularly targeted therapies may be limited by co-occurring mutations within a tumor. Conversely, these alterations may confer collateral vulnerabilities that can be therapeutically leveraged. KRAS-mutant lung cancers are ...

Xiaojie Tong,Tong Shen,Song Li et al. Xiaojie Tong et al.

CDK4/6 is the candidate therapeutic target for KRAS-mutant NSCLC. However, its frequent primary and acquired resistance limits its potential clinical application. Recently it had been shown that BRD4 up-regulation induced conferred resistan...

Shahad Khalid Hussein Hussein,Olga Tcacenco Shahad Khalid Hussein Hussein

Histiocytic sarcoma (HS) is a rare and aggressive malignant neoplasm from histiocytic cells. This case report describes a 52-year-old male with HS involving multiple abdominal sites, diagnosed through imaging, histopathology, and immunohist...

Mohammad Rezazadeh,Ahmadreza Kheradpishe,Amirreza Kamyabi et al. Mohammad Rezazadeh et al.

Early-onset colorectal cancer (EO-CRC), defined as colorectal adenocarcinoma diagnosed before age 50, is increasing globally, with distinct clinicopathologic and molecular features compared to adult-onset disease. While risk factors such as...

Yurong Xiang,Qiang Liu,Kang Liu et al. Yurong Xiang et al.

Multi-drug combination therapy is one of the most effective strategies for the treatment of drug-resistant and advanced tumors. Modern nanodrug delivery systems are crucial for multi-drug combination therapy and gene therapy. However, resea...

Yaojin Zhu,Zhenqian Chen,Guoyuan Wu et al. Yaojin Zhu et al.

Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations are a common type of oncogenic mutation, widely observed in various cancers. The trafficking chaperone PDE6D (or PDEδ) has been proposed as an alternative target for KRAS, which...