Molecular and serological assessment of the therapeutic efficacy of Ivermectin Loaded nanoparticles on Trichinella spiralis experimentally [0.03%]
伊维菌素纳米颗粒对实验性旋毛虫的治疗效果的分子和血清学评价
Howayda S F Moawad,Alaa M Elgendy,Sabah M A Mohamed et al.
Howayda S F Moawad et al.
Trichinosis is a real threat to public health that infects humans and animals. Current treatments have high resistance and limited bioavailability. Consequently, it is imperative to enhance the bioavailability of these drugs by developing n...
Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy [0.03%]
HSF4缺乏通过上调伴侣介导的自噬增加小细胞外囊泡的分泌
Jingjing Liu,Xuhui Liu,Xiaohang Xie et al.
Jingjing Liu et al.
Small extracellular vesicles (SEVs) are membrane-bound vesicles secreted by cells that facilitate intercellular communication. This study reveals how heat shock transcription factor 4 (HSF4) deficiency regulates SEV secretion in lens epithe...
Baixue Liu,Youfei Lang,Yujie Li et al.
Baixue Liu et al.
Genetic mutations in Hsf4 cause developmental defect of lens at postnatal age. However, the regulatory effect of Hsf4 mutations on retinal homeostasis have not been elucidated. Here we found that HSF4 expresses in retinal and its expression...
Extracellular matrix stiffness regulates colorectal cancer progression via HSF4 [0.03%]
基质刚度通过HSF4调控结直肠癌进展
Kangtao Wang,Siyi Ning,Shuai Zhang et al.
Kangtao Wang et al.
Background: Colorectal cancer (CRC) has high incidence and mortality rates, with severe prognoses during invasion and metastasis stages. Despite advancements in diagnostic and therapeutic technologies, the impact of the t...
A mechanistic study on the interaction effects between legacy and pollutants of emerging concern: A case study with B[a]P and diclofenac [0.03%]
一种典型持久性有机污染物和新兴污染物的相互作用效应机制研究：以BaP和双氯芬酸为例的研究
Carla Martins,Lara M Carvalho,Inês Moutinho Cabral et al.
Carla Martins et al.
Impaired eye function by action of DFC and B[a]P combined may be another AO, in the case caused by ocular degeneration following the suppression of biologic processes and molecular functions involved in eye development and its functionalities, possibly linked to hindered regulation of the expression of hsf4
Nipple adenoma: A clinicopathological study over a period of six years in tertiary care center [0.03%]
六年期间 nipple腺瘤的临床病理研究
H S Fathima Afshan,M Nirmal Daniel,A Santhosh Raj et al.
H S Fathima Afshan et al.
Background: Nipple adenoma (NA) is a rare benign neoplasm of the nipple arising from the lactiferous duct. Often seen in middle aged women, presenting as a nodule, erosive, or ulcerative lesion and associated with serous ...
Factors Influencing Data Quality in Electronic Health Record Systems in 50 Health Facilities in Rwanda and the Role of Clinical Alerts: Cross-Sectional Observational Study [0.03%]
卢旺达50家医疗机构电子健康记录系统数据质量问题的影响因素及临床预警的作用：横断面观察性研究
Hamish S F Fraser,Michael Mugisha,Ian Bacher et al.
Hamish S F Fraser et al.
Background: Electronic health records (EHRs) play an increasingly important role in delivering HIV care in low- and middle-income countries. The data collected are used for direct clinical care, quality improvement, progr...
Observational Study
JMIR public health and surveillance. 2024 Jul 3:10:e49127. DOI:10.2196/49127 2024
The heat shock factor 20-HSF4-cellulose synthase A2 module regulates heat stress tolerance in maize [0.03%]
热休克因子20-HSF4-纤维素合酶A2模块调节玉米的高温胁迫耐受性
Ze Li,Zerui Li,Yulong Ji et al.
Ze Li et al.
Temperature shapes the geographical distribution and behavior of plants. Understanding the regulatory mechanisms underlying the plant heat stress response is important for developing climate-resilient crops, including maize (Zea mays). To i...
ZNF692 Promotes the Progression of Colon Adenocarcinoma by Regulating HSF4 Expression [0.03%]
ZNF692通过调控HSF4表达促进结肠腺癌进展
Zhengpeng Yang,Hao Wu,Defu Dai et al.
Zhengpeng Yang et al.
Background: Colon adenocarcinoma (COAD) is one of the most common cancer happened in gastrointestinal tract, with the overall incidence rate of 4%-5% among human beings. Like most malignancies, we uncovered the exact mech...
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