Rita Casetti,Fabiola Ciccosanti,Harpreet Kaur Lamsira et al.
Rita Casetti et al.
Background: Autophagy is the primary catabolic process responsible for degrading intracellular components and potentially harmful cytosolic entities by delivering them to lysosomes. Notably, this mechanism is crucial for ...
Decrease in drug-drug interactions between antiretroviral drugs and concomitant therapies in older people living with HIV-1 switching to bictegravir/emtricitabine/tenofovir alafenamide [0.03%]
接受比克替拉韦/恩曲他滨/特诺福韦阿拉芬酰胺治疗的老年人 HIV-1 患者的药物间相互作用减少
Leonardo Calza,Maddalena Giglia,Alberto Zuppiroli et al.
Leonardo Calza et al.
Clinical trials of triple regimen bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) demonstrated potent efficacy and favorable safety in both antiretroviral therapy-naïve and -experienced people living with HIV (PLWH), in assoc...
Coronavirus replicase epitopes induce cross-reactive CD8 T cell responses in SARS-CoV-2-naive people with HIV-1 [0.03%]
冠状病毒复制酶表位诱导HIV-1患者产生对SARS-CoV-2交叉反应的CD8 T细胞免疫反应
Katja G Schmidt,Paulina Geißler,Ev-Marie Schuster et al.
Katja G Schmidt et al.
Cross-reactive T cell immunity between common cold coronaviruses and SARS-CoV-2 may influence COVID-19 susceptibility. To identify cross-reactive CD8 T cell epitopes, we analyzed responses to 21 homologous SARS-CoV-2 replicase peptides in 1...
People with four-class drug-resistant HIV-1 may have low levels of intact DNA [0.03%]
四类药物耐药HIV-1患者可能具有较低水平的完整DNA
Camilla Muccini,Vincenzo Spagnuolo,Maurizio Zazzi et al.
Camilla Muccini et al.
We evaluated the HIV-1 reservoir in people with four-class drug-resistant (4DR) virus compared with those without drug resistance. Using the intact proviral DNA assay, we found that both groups had similar levels of intact HIV-1 DNA, sugges...
Efficacy, safety, and anti-inflammatory properties of the switch to a doravirine-based regimen among antiretroviral-experienced elderly people living with HIV-1: the DORAGE cohort [0.03%]
多瑞韦林为基础的方案在有经验的年长HIV-1患者中的疗效、安全性和抗炎特性：DORAGE队列研究
Alessandro Lazzaro,Gregorio Egidio Recchia,Federica Alessi et al.
Alessandro Lazzaro et al.
Doravirine (DOR) is a novel antiretroviral agent with a favorable resistance profile and high tolerability. However, evidence is limited on DOR among elderly people living with HIV (PLWH) and whether it might modulate chronic inflammation. ...
A graph neural network-based model with out-of-distribution robustness for enhancing antiretroviral therapy outcome prediction for HIV-1 [0.03%]
一种基于图神经网络的具有分布外稳健性的增强型抗逆转录病毒治疗结果预测模型用于HIV-1患者
Giulia Di Teodoro,Federico Siciliano,Valerio Guarrasi et al.
Giulia Di Teodoro et al.
Predicting the outcome of antiretroviral therapies (ART) for HIV-1 is a pressing clinical challenge, especially when the ART includes drugs with limited effectiveness data. This scarcity of data can arise either due to the introduction of a...
Adherence to antiretroviral therapy among HIV-1 patients from sub-Saharan Africa: a systematic review [0.03%]
东非HIV-1患者抗逆转录病毒治疗的依从性系统评价研究
Pedro R S Almeida,Carlos A C Rafael,Victor Pimentel et al.
Pedro R S Almeida et al.
More than two decades after introducing antiretroviral therapy (ART), several challenges still prevail in keeping well people living with HIV, even with "Test and Treat" and/or "Rapid Start of ART" initiatives, as well as the scale-up of AR...
Treatment Management Challenges in Naïve and Experienced HIV-1-Infected Individuals Carrying the M184V Mutation [0.03%]
初始感染及经治M184V突变HIV-1患者治疗管理面临的挑战
Iordanis Mimtsoudis,Olga Tsachouridou,Karolina Akinosoglou et al.
Iordanis Mimtsoudis et al.
M184V is a single-base mutation in the YMDD domain of reverse transcriptase (RT). The M184V resistance-associated mutation (RAM) is related to virological unresponsiveness to lamivudine (3TC) and emtricitabine (FTC) and induces high-level r...
Real-world effectiveness and safety of switching to dolutegravir/lamivudine among people living with HIV-1 aged over 50 years who are virologically suppressed [0.03%]
评估并切换至多替拉韦/拉米夫定在抑制病毒的50岁以上HIV-1患者中的有效性和安全性
C Piñeiro,S Policarpo,C Caldas et al.
C Piñeiro et al.
Objectives: People living with HIV face several challenges as they age, including the potential for polypharmacy and increased susceptibility to drug-related adverse effects. Thus, effective and well-tolerated regimens wi...
Human leukocyte antigen HLA-B*57:01 status in HIV-1 patients developing hypersensitivity reactions in Benin: a pilot study [0.03%]
贝宁HIV-1患者HLA-B*57:01基因型与药物过敏反应相关性的一项前瞻性研究
Adefounke Prudencia Adechina,Yaou Pierrot Assogba,Edmond Tchiakpe et al.
Adefounke Prudencia Adechina et al.
Background: Antiretroviral drugs in people living with HIV-1 (PLHIV-1) often trigger side effects which may lead to discontinuation or failure of treatment. Human Leukocyte Antigen B*57:01 (HLA-B*57:01) allele is known to...
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