Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis [0.03%]
Goreisan通过调节ICAT-β连环蛋白/ERK轴来缓解由HFD/L-NAME诱导的射血分数保留的心力衰竭中的心脏肥大和舒张功能障碍
Yoko Shojima Isayama,Shouji Matsushima,Keisuke Shinohara et al.
Yoko Shojima Isayama et al.
Heart failure with preserved ejection fraction (HFpEF), characterized by cardiac hypertrophy and diastolic dysfunction, is increasing worldwide. Goreisan (GRS) is a traditional herbal formulation; its component attenuates cardiomyocyte hype...
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats [0.03%]
高脂肪饮食和L-NAME引起的代谢功能障碍优先影响大鼠海马体线粒体，影响其空间记忆
Wembley R Vilela,Lisley S Ramalho,Luiz R G Bechara et al.
Wembley R Vilela et al.
High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effects on brain functions related to learning and memory. This study aimed to evaluate mitochondrial markers and function,...