Adaptive SELEX strategies against HCV core protein lead to the same aptamer [0.03%]
对抗HCV核心蛋白的适应性SELEX策略得到相同的适配体
Ana García-Sacristán,Elba Mauriz,Marta García-Hernández et al.
Ana García-Sacristán et al.
Herein, we demonstrate the accuracy of aptamer selection among different SELEX procedures, in different labs, using different variations of the same target and slightly different aptamer initial libraries. In our lab, we have selected DNA a...
Hepatitis B Virus X Protein Stimulates Hepatitis C Virus (HCV) Replication by Protecting HCV Core Protein from E6AP-Mediated Proteasomal Degradation [0.03%]
乙型肝炎病毒X蛋白通过保护HCV核心蛋白免受E6AP介导的蛋白酶体降解来刺激丙型肝炎病毒（HCV）复制
Hyunyoung Yoon,Jiwoo Han,Kyung Lib Jang
Hyunyoung Yoon
Most clinical and experimental studies have suggested that hepatitis C virus (HCV) is dominant over hepatitis B virus (HBV) during coinfection, although the underlying mechanism remains unclear. In this study, we found that the HBV X protei...
The Transgene Expression of the Immature Form of the HCV Core Protein (C191) and the LncRNA MEG3 Increases Apoptosis in HepG2 Cells [0.03%]
丙型肝炎病毒核心蛋白(C191)和长链非编码RNA(MEG3)的转基因表达可增加HepG2细胞凋亡率
Dina Mofed,Salwa Sabet,Ahmed A Baiomy et al.
Dina Mofed et al.
Long non-coding RNAs (lncRNAs) are regulated in cancer cells, including lncRNA MEG3, which is downregulated in Hepatocellular Carcinoma (HCC). In addition, hepatitis C virus (HCV) core proteins are known to dysregulate important cellular pa...
HCV inhibits M2a, M2b and M2c macrophage polarization via HCV core protein engagement with Toll-like receptor 2 [0.03%]
HCV通过HCV核心蛋白与Toll样受体2的结合抑制M2a，M2b和M2c巨噬细胞极化
Shixing Zhao,Meng Si,Xianpei Deng et al.
Shixing Zhao et al.
Hepatitis C virus (HCV) establishes a persistent infection in most patients, eventually leading to chronic hepatitis C (CHC), cirrhosis and hepatocellular carcinoma. Our previous study revealed that HCV core protein (HCVc) inhibited the dif...
HCV Core protein represses DKK3 expression via epigenetic silencing and activates the Wnt/β-catenin signaling pathway during the progression of HCC [0.03%]
HCV核心蛋白通过表观遗传沉默DKK3并激活Wnt/β-连锁蛋白信号通路促进肝癌进展
Xiaoyan Wang,Yun Zhou,Chunfu Wang et al.
Xiaoyan Wang et al.
The Wnt/β-catenin signaling pathway is frequently activated in hepatocellular carcinoma (HCC). A number of studies have focused on the aberrant hypermethylation of the DKK family proteins and its role in regulating the activation of specif...
HCV Core Protein Induces Chemokine CCL2 and CXCL10 Expression Through NF-κB Signaling Pathway in Macrophages [0.03%]
巨噬细胞中HCV核心蛋白通过NF-κB信号通路诱导趋化因子CCL2和CXCL10的表达
Xiaotian Song,Xue Gao,Yadong Wang et al.
Xiaotian Song et al.
HCV core protein is the first structural protein synthesized during hepatitis C virus (HCV) infection and replication. It is released from virus infected liver cells and mediates multiple functions to affect host cell response. The innate i...
A simple method to purify recombinant HCV core protein expressed in Pichia pastoris for obtaining virus-like particles and producing monoclonal antibodies [0.03%]
一种简单的方法纯化出在毕赤酵母中表达的重组HCV核心蛋白以获得病毒样颗粒并制备单克隆抗体
Anastasia Pechelyulko,Zhanna Andreeva-Kovalevskaya,Dmitriy Dmitriev et al.
Anastasia Pechelyulko et al.
In this study, we describe an optimized method of obtaining virus-like particles (VLPs) of the recombinant hepatitis C virus (HCV) core protein (HCcAg) expressed in yeast cells (Pichia pastoris), which can be used for the construction of di...
Impact of IL28 Genotypes and Modeling the Interactions of HCV Core Protein on Treatment of Hepatitis C [0.03%]
IL28基因多态性对丙型肝炎治疗的影响及HCV核心蛋白作用的研究
Tayebeh Hashempour,Behzad Dehghani,Zahra Musavi et al.
Tayebeh Hashempour et al.
Background: Mutations in the core CVR region of hepatitis C virus (HCV) and polymorphisms of interleukin 28B (IL28B) are associated with progression toward liver disease and in response to therapy. In addition, interactio...
Behzad Dehghani,Tayebeh Hashempour,Zahra Hasanshahi et al.
Behzad Dehghani et al.
Hepatitis C virus (HCV) infection is a serious global health problem and a cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Bioinformatics software has been an effective tool to study the HCV genome as well a...
Mechanistic study of interaction between IL-22 and HCV core protein in the development of hepatocellular carcinoma among liver transplant recipients [0.03%]
肝移植受者中IL-22与HCV核心蛋白在肝癌发生发展中的相互作用及机制研究
Saleha Resham,Muhammad Saalim,Sobia Manzoor et al.
Saleha Resham et al.
Background: Hepatitis C virus (HCV) infects more than 170 million people worldwide that represents a major threat to global public health. Several viruses including HCV have developed mechanisms against the cellular respo...
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