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Hongli Wang,Chu Li,Qian Li et al. Hongli Wang et al.
Background: Childhood epilepsy is a common neurological syndrome with complex etiology and recurrent seizures. It seriously affects the growth and development of child patients. ...
Nadia Leen,Antoin de Weijer,Marco Boks et al. Nadia Leen et al.
Background: During military deployment, stress regulation is vital to protect against the development of anxiety and trauma-related symptoms. Brain endocannabinoids play an important role in stress regulation and previous...
Hugo-Henrique Silva,Valéria Tavares,Maria-Raquel G Silva et al. Hugo-Henrique Silva et al.
Genetic variants are recognized to affect athletic performance, partially by modulating competition-facilitating behavior. In this study, the role of three genetic variants previously linked to athlete status was investigated among elite vo...
Jennifer Spohrs,Martin Ulrich,Georg Grön et al. Jennifer Spohrs et al.
Gold standard treatments for anxiety- and trauma-related disorders focus on exposure therapy promoting extinction learning and extinction retention. However, its efficacy is limited. Preclinical and particularly animal research has been abl...
Soundarya Soundararajan,Narjis Kazmi,Alyssa T Brooks et al. Soundarya Soundararajan et al.
Sleep disturbances are common among individuals with alcohol use disorder (AUD) and may not resolve completely with short-term abstinence from alcohol, potentially contributing to relapse to drinking. The endocannabinoid system (ECS) is ass...
Silvano Presciuttini,Giancarlo Carli,Enrica L Santarcangelo Silvano Presciuttini
Fatty acid amide hydrolase (FAAH) degrades the endogenous endocannabinoid (eCB) anandamide and might be involved in the response to suggestions of analgesia in subjects with high hypnotizability scores (highs). Since the A allele of the FAA...
Rohan H C Palmer,John E McGeary,Valerie S Knopik et al. Rohan H C Palmer et al.
Background: Polymorphisms in cannabinoid receptor type 1 (encoded by CNR1) and fatty acid amide hydrolase (encoded by FAAH) have been associated with cannabis dependence, but it remains unknown whether variation within these genes influence...
Maw Shin Sim,Ahmad Hatim,Gavin Paul Reynolds et al. Maw Shin Sim et al.
Aim: FAAH is a membrane enzyme that terminates the activity of a large class of endogenous signaling lipids. Recent studies suggest that the FAAH Pro129Thr polymorphism is a common mutation in the FAAH gene that is signif...