Jin-Hui Shi,Qi-Long Tang,Jin-Hong Wang et al. Jin-Hui Shi et al.

Disrupted glutamate-glutamine cycling causes chronic excitotoxicity, a key driver of cognitive deficits in Alzheimer's disease (AD), though regulatory mechanisms remain unclear....Keywords: alzheimer's disease (AD); glutamate homeostasis; glutamate transporter‐1 (GLT‐1); pigment epithelium‐derived factor (PEDF). © 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.

Jiajie Wei,Karin Bystol,Leah Alabanza et al. Jiajie Wei et al.

Noroviruses are a leading cause of acute gastroenteritis across all age groups, associated with ∼18% of diarrheal disease globally. Infections span a broad clinical spectrum, ranging from asymptomatic and self-limiting illnesses to hospitalizations and deaths.

Yoko Shigemoto,Hiroshi Matsuda,Norihide Maikusa et al. Yoko Shigemoto et al.

Objectives: Although recent advances in network analysis have enabled individual assessment of brain networks using gray matter images, only a few studies have used gray matter networks in Parkinson's disease (PD) and were limited to a few patients with early-stage PD....We aimed to investigate gray matter network alterations and their correlation with clinical parameters, including disease severity and nigrostriatal degeneration, in patients with early- to late-stage PD....Global and local network properties were analyzed using a graph-theoretical approach, and their correlations with disease severity, motor disability, and nigrostriatal degeneration were assessed....Discussion: Our findings suggest that the gray matter network in patients with PD moved toward a less optimal random network than that of HC as the disease progressed.

Shixing Wu,Wei Liu,Changying Zhang Shixing Wu

Background: Polygonatum sibiricum polysaccharide (PSP) is known for its anti-inflammatory and cognitive improvement effects. However, its potential to alleviate neurotoxicity in Alzheimer's diseafse (AD) has not been thor...

Maciej Rachwalik,Dorota Zyśko,Richard Sutton et al. Maciej Rachwalik et al.

However, its impact on outcomes in patients with advanced coronary artery disease remains unclear. The aim of this study was to assess the prevalence and prognostic value of OH in patients undergoing isolated coronary artery bypass grafting (CABG).

P Schrobback,J Aboah,K Richards et al. P Schrobback et al.

Outbreaks of emergency animal diseases such as African swine fever (ASF) and foot-and-mouth disease (FMD) are typically managed through regulated control measures, including tracing, surveillance, movement restrictions, culling, disposal and decontamination....This study aimed to map the material flow within the Australian pork supply chain and to identify the potential socio-economic implications of disease control interventions....The findings of this work emphasise the importance of decision-makers being well informed about the effects of supply chain disruptions and the socio-economic consequences of disease control decisions.

Ming-Ling Chang,Jur-Shan Cheng,Jennifer Tai et al. Ming-Ling Chang et al.

Background: The effects of genetic predispositions and steatotic liver disease (SLD) on the outcomes of chronic hepatitis C (CHC) patients with sustained virological responses (SVRs) remain unknown.

Takayuki Otani,Toshihisa Ichiba,Yuji Okazaki et al. Takayuki Otani et al.

Multivariable logistic regression analysis identified the following independent predictors of altered mental status: advanced age [odds ratio (OR), 1.04; 95% confidence interval (CI), 1.02-1.06], history of cerebrovascular disease (OR, 2.52; 95% CI 1.45-4.36), dementia (OR, 3.57; 95% CI 2.04-6.23), mental

Ana L McCracken,Mara B Antonoff Ana L McCracken

Siu-Yuan Huang,Makaelah Murray,Angelique Rubio et al. Siu-Yuan Huang et al.

Conclusions: Breast cancer patients diagnosed at ≥ 80 years of age who received screening mammography presented with earlier-stage disease and had improved DFS and OS compared with the unscreened cohort.