Preoperative Echocardiographically Derived Mean dP/dTic Predicts Early Post-operative Dysfunction in Children Undergoing Mitral Valve Surgery [0.03%]
儿童二尖瓣手术的术前多普勒超声心动图平均dP/dTic预测早期术后功能障碍
Addison Gearhart,Nikhil Thatte,Sunakshi Bassi et al.
Addison Gearhart et al.
Mean dP/dtic is a quantitative measurement of ventricular function that can be obtained noninvasively by echocardiography. In adults with mitral regurgitation (MR), it has been shown to be a more sensitive predictor of postoperative left ve...
[A Case of Long-Term Survival with Tumor Resection and DOX plus DTIC Therapy for Desmoid Tumor after FAP Surgery] [0.03%]
术后DA方案化疗结合手术治疗一例低度恶性(desmoid)肿瘤长期存活病例报告
Takashi Takeda,Katsuki Danno,Shiki Fujino et al.
Takashi Takeda et al.
The patient is a 22-year-old, female. She had a family history of familial adenomatous polyposis(FAP)and a prophylactic total colorectal resection was performed for FAP at age of 18. She presented with fever and abdominal distention and pal...
Case Reports
Gan to kagaku ryoho. Cancer & chemotherapy. 2023 Mar;50(3):401-403. DOI: 2023
CD47-mediated DTIC-loaded chitosan oligosaccharide-grafted nGO for synergistic chemo-photothermal therapy against malignant melanoma [0.03%]
用于协同治疗恶性黑色素瘤的CD47介导的DTIC负载式壳聚糖寡糖接枝氮化硼纳米片材料
Xiaozhen Zhan,Wanqing Teng,Kai Sun et al.
Xiaozhen Zhan et al.
Nano-graphene oxide (nGO), an effective drug nanocarrier, is used for simultaneous photothermal therapy (PTT) and near-infrared fluorescence imaging. Dacarbazine (DTIC) is used in the treatment of melanoma with limited clinical efficacy. PT...
Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients [0.03%]
抗原特异性及肽疫苗接种前DTIC治疗不同地塑造黑色素瘤患者的免疫检查点表达模式、抗肿瘤功能和TCR库
Belinda Palermo,Ornella Franzese,Cosmo Di Donna et al.
Belinda Palermo et al.
We have recently described that DNA-damage inducing drug DTIC, administered before peptide (Melan-A and gp100)-vaccination, improves anti-tumor CD8+ Melan-A-specific T-cell functionality, enlarges the Melan-A+ TCR repertoire and impacts the...
Ira Kantrowitz-Gordon,Karen Hays,Olumide Kayode et al.
Ira Kantrowitz-Gordon et al.
Purpose: The purpose of this report is to describe, for the first time, the pharmacokinetics of dacarbazine (DTIC) and its metabolites [5-[3-methyl-triazen-1-yl]-imidazole-4-carboxamide (MTIC), 5-[3-hydroxymethyl-3-methyl...
The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model [0.03%]
携带HF10溶瘤HSV的小鼠黑色素瘤模型中与DTIC联合治疗的疗效研究
Rui Tanaka,Fumi Goshima,Shinichi Esaki et al.
Rui Tanaka et al.
Advanced melanoma has long been treated with chemotherapy using cytotoxic agents like dacarbazine (DTIC), but overall survival rates with these drugs have been generally low. Recently, immunoregulatory monoclonal antibodies and molecularly ...
Sequential Combination Chemotherapy of Dacarbazine (DTIC) with Carboplatin and Paclitaxel for Patients with Metastatic Mucosal Melanoma of Nasal Cavity and Paranasal Sinuses [0.03%]
达卡巴嗪与卡铂和紫杉醇序贯联合化疗治疗鼻腔和副鼻窦黏膜恶性黑色素瘤转移患者的疗效观察
W Omata,A Tsutsumida,K Namikawa et al.
W Omata et al.
By the recent introduction of molecular targeting drugs against BRAF mutation and immune checkpoint inhibitors, the prognosis of patients with melanoma in advanced stage is now improving, but still in the minority. Mucosal melanoma lacks th...
Low dose DTIC is effective and safe in pretreated patients with well differentiated neuroendocrine tumors [0.03%]
低剂量DTIC用于治疗经其他药物治疗过的类癌等神经内分泌肿瘤患者有效且安全
Daniela Mueller,Sebastian Krug,Moushumee Majumder et al.
Daniela Mueller et al.
Background: Streptozocin (STZ) based chemotherapy is recommended for patients with metastatic pancreatic neuroendocrine tumors (pNET). Temozolomide as mono- or combination therapy has been suggested to be a promising alte...
DR5 mAb-conjugated, DTIC-loaded immuno-nanoparticles effectively and specifically kill malignant melanoma cells in vivo [0.03%]
一种新型免疫纳米颗粒通过特异性结合恶性黑色素瘤细胞的DR5抗原，高效诱导肿瘤细胞凋亡
Baoyue Ding,Wei Zhang,Xin Wu et al.
Baoyue Ding et al.
We combined chemo- and immunotherapies by constructing dual therapeutic function immuno-nanoparticles (NPs) consisting of death receptor 5 monoclonal antibody (DR5 mAb)-conjugated nanoparticles loaded with dacarbazine (DTIC) (DTIC-NPs-DR5 m...
Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma [0.03%]
BRAF和NRAS低表达与DTIC治疗转移性黑色素瘤的临床疗效及预后相关
Einar Birkeland,Christian Busch,Elisabet Ognedal Berge et al.
Einar Birkeland et al.
Metastatic melanoma is characterized by a poor response to chemotherapy. Furthermore, there is a lack of established predictive and prognostic markers. In this single institution study, we correlated mutation status and expression levels of...
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