Synthesis, structure, DNA docking, pharmacokinetics/ADMET, Hirshfeld surface analysis, and antimicrobial studies on biphenyl appended pyrrolidine complexes [0.03%]
联苯基吡咯烷配合物的合成、结构、DNA相互作用、药代动力学/ADMET、Hirshfeld表面分析及抗菌活性研究
Koyal Pattanaik,Popuri Sureshbabu,Elanseralathan Sujitha et al.
Koyal Pattanaik et al.
Biphenyl anchored pyrrolidine complexes [MLCl2], [where M = Co (1), Ni (2), Cu (3) and Zn (4); L = 6-(2-(pyrrolidin-1-yl)ethyl)-6,7-dihydro-5H-dibenzo[c,e]azepine] were synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI...
Jiayu Wang,Hehan Wei,Bin Xia
Jiayu Wang
Structural dynamics of the wild-type p53 DNA-binding domain and hotspot mutants reveal oncogenic conformational shifts [0.03%]
野生型p53DNA结合域及其热点突变体的结构动力学揭示了致癌构象转换
Ziqian Zhao,Gang Wang,Xiaoxiao Wu et al.
Ziqian Zhao et al.
The tumor suppressor protein p53, widely known for the potency and diversity of its functions, acts as a critical barrier to tumorigenesis. Mutations in p53, particularly within its DNA-binding domain (DBD), compromise its tumor suppressing...
Phosphorylation of the protamine-like protein from baculovirus affects its DNA binding and virus propagation [0.03%]
杆状病毒类精胺蛋白的磷酸化影响其DNA结合及病毒增殖功能
Qian Cheng,Siqi Zhu,Yanrong Lv et al.
Qian Cheng et al.
Viral DNA-binding proteins, a type of protamine-like protein, pack the viral genome and promote late viral gene expression. In baculovirus Autographa californica multiple nucleopolyhedrovirus, DNA-binding protein P6.9 plays a crucial role i...
Single-stranded DNA binding proteins are essential components of the architectural LDB1 protein complex [0.03%]
单链DNA结合蛋白是结构蛋白LDB1复合物的重要组成部分
Xiaokang Wang,Nicholas G Aboreden,Ying Cai et al.
Xiaokang Wang et al.
Transcriptional enhancers are brought into proximity with promoters via chromatin looping. The architectural transcription cofactor LDB1 facilitates spatial connectivity among enhancers and promoters but whether this occurs through simple d...
Syntheses of benzothiazole amidoximes and arylimidamides and evaluation of their ADME and DNA binding properties and activity against Trypanosoma brucei [0.03%]
苯并噻唑肟胺和芳基咪胺的合成及其ADME、DNA结合性质和对抗布氏锥虫活性的研究
Valentina Rep Kaulić,Martina Piškor,Sanja Koštrun et al.
Valentina Rep Kaulić et al.
Novel 6-amidoxime- and 6-arylimidamide-substituted benzothiazoles were synthesised to investigate their activity against Trypanosoma brucei, the causative agent of African trypanosomiasis. Benzothiazole amidoxime 12b, with diethylaminoethyl...
OptimDase: An Algorithm for Predicting DNA Binding Sites with Combined Feature Encoding [0.03%]
基于组合特征编码的DNA结合位点预测算法OptimDase
Zhendong Liu,Jun S Liu,Dongqing Wei et al.
Zhendong Liu et al.
Identifying DNA binding sites remains a critical task in bioinformatics, with applications ranging from gene regulation studies to drug design. Although progress has been made in computational techniques, we still face challenges such as da...
Selective engineering of condensation properties of single-stranded DNA binding (SSB) protein via its intrinsically disordered linker region [0.03%]
通过单链DNA结合（SSB）蛋白内在无序的连接区域选择性工程化凝聚特性
Péter Ecsédi,Dávid Érfalvy,Zoltán J Kovács et al.
Péter Ecsédi et al.
Single-stranded DNA binding (SSB) proteins are essential components of genome metabolism in both bacteria and eukaryotes. Recently demonstrated condensation propensities have placed SSB functions in a new context regarding the organization ...
A role for pH dynamics regulating transcription factor DNA-binding selectivity [0.03%]
pH动力学在调节转录因子DNA结合选择性中的作用
Kyle P Kisor,Diego Garrido Ruiz,Matthew P Jacobson et al.
Kyle P Kisor et al.
Intracellular pH (pHi) dynamics regulates diverse cell processes such as proliferation, dysplasia, and differentiation, often mediated by the protonation state of a functionally critical histidine residue in endogenous pH sensing proteins. ...
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