Blockade of colon cancer metastasis via single and double silencing of PCSK7/ PCSK9: enhanced T cells cytotoxicity in mouse and human [0.03%]
通过单个和双个沉默PCSK7 / PCARK9阻断结肠癌转移：小鼠和人类的T细胞细胞毒性增强
Chloé Porcheron,Mailys Le Devehat,Anna Roubtsova et al.
Chloé Porcheron et al.
We also estimated the cell surface expression of checkpoint proteins in CD4+ and CD8+ T cells from healthy human subjects in which PCSK7 expression was silenced by CRISPR Cas9 gRNA knockdown.
Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission [0.03%]
Envelope基因的缺失通过改变Spike定位和增加细胞间传播来减弱新型冠状病毒的感染
Hannah L Fischer,Christopher Kline,W Paul Duprex et al.
Hannah L Fischer et al.
Electron and immunofluorescence microscopy and virology assays showed that ΔE SARS-CoV-2 increased cell surface expression of Spike (S) glycoprotein, leading to reduced S incorporation into ΔE SARS-CoV-2 particles and promotion of increased cell-to-cell transmission that evades neutralizing antibody
Neutrophils in the Bone Marrow Express DEC205, Guiding Their Migration to Inflamed Tissues [0.03%]
骨髓中的中性粒细胞表达DEC205指导它们迁移到炎症组织
Shiying Jin,Xuan Lei,Sonali Singh et al.
Shiying Jin et al.
Analysis of cell surface expression of DEC205 in neutrophils at different maturation stages and anatomical locations revealed its downregulation upon in vitro activation and during tissue infiltration, such as in skin inflammation and thioglycolate-induced peritonitis.
Philipp M Hagemann,Angelique N Kenyon,Alfredo Cabrera-Orefice et al.
Philipp M Hagemann et al.
Deficiency of CD151 decreased cell surface expression of alpha integrin subunits L (ITGAL) and M (ITGAM), and impaired ICAM-1-mediated cell spreading.
NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors [0.03%]
NECTIN4在非小细胞肺癌细胞中调节CD155的细胞表面表达并诱导PD-1抑制剂耐药性
Shun Mizusaki,Yasuto Yoneshima,Eiji Iwama et al.
Shun Mizusaki et al.
In this study, we demonstrated that NECTIN4 regulated the cell surface expression and stabilization of CD155 by interacting and co-localizing with CD155 on the cell surface.
Fever-range temperature alters continual efferocytosis mediated by mouse pro-inflammatory macrophages [0.03%]
发热范围的温度改变小胶质细胞介导的连续性促炎反应摄取作用
Mathieu Vetter,Melissa Maraux,Francis Bonnefoy et al.
Mathieu Vetter et al.
As this gene encodes a protease that sheds the efferocytic receptor Mer, we determined cell surface expression of Mer and quantified soluble Mer in the culture supernatants of pro-inflammatory macrophages exposed to febrile temperature.
CLN-619, a MICA/B monoclonal antibody that promotes innate immune cell-mediated antitumor activity [0.03%]
一种MICA/B单克隆抗体CLN-619可促进天然免疫细胞的抗肿瘤活性
Kerry A Whalen,Catherine C Henry,Naveen K Mehta et al.
Kerry A Whalen et al.
CLN-619 increased the level of cell surface expression of MICA/B and concomitantly decreased the levels of soluble MICA/B in cell culture assays. Treatment of cancer cell lines with CLN-619 induced antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis.
Ex Vivo Overactivation of Lymphocyte Subsets in Fibrotic Hypersensitivity Pneumonitis Is Blunted by a Sphingosine-1-Phosphate Receptor Ligand [0.03%]
纤维化过敏性肺炎中淋巴细胞亚群的体外过度活化被鞘氨醇-1-磷酸受体配体抑制
Olivier Courtemanche,Carole-Ann Huppé,Pascale Blais-Lecours et al.
Olivier Courtemanche et al.
In isolated B cells stimulated with a TLR9 ligand, ozanimod reduced cell surface expression of CD69, CD86, and CD40, as well as TNF and IL-6 accumulation in supernatant.
2'-FL in Dairy Matrices Attenuates Allergic Symptoms in Mice by Reducing BLG Hypersensitivity and Modulating Gut Microecology [0.03%]
2'-岩藻糖基乳糖通过降低BLG过敏并调节肠道微生态减轻小鼠过敏症状研究——以 dairy matrices 为载体
Xintong Chen,Fan Yang,Tianliang Bai et al.
Xintong Chen et al.
Both 2'-FL-β-LG sensitization and oral 2'-FL intervention reduced allergic symptoms, specific antibodies (IgE, IgG, and IgG2a), inflammatory cytokine levels, and intestinal damage. 2'-FL also shifted T-cell differentiation, reduced cell surface expression of DC receptors, and enhanced gut microbial diversity
LGALS3BP antibody-drug conjugate enhances tumor-infiltrating lymphocytes and synergizes with immunotherapy to restrain neuroblastoma growth [0.03%]
lgals3bp抗体-药物偶联物可增强肿瘤浸润淋巴细胞并协同免疫疗法抑制神经母细胞瘤生长
Ilaria Cela,Emily Capone,Asia Pece et al.
Ilaria Cela et al.
Moreover, we show that in the syngeneic NXS2 neuroblastoma model, DM4 treatment induces cell surface expression of ICD markers calreticulin, HSP70, and HSP90, and an increased PD-L1 expression in vitro, followed by enhanced tumor-infiltrating lymphocytes in vivo.
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