Prenatal efavirenz exposure is independently associated with maternal, but not fetal CYP2B6 genotype [0.03%]
孕前暴露于依非韦伦与母体和胎儿细胞色素P450 2B6基因型的独立关系无关
Oluwasegun Eniayewu,Abdulafeez Akinloye,Babajide Shenkoya et al.
Oluwasegun Eniayewu et al.
Objectives: Understanding the influence of fetal and maternal genetics on prenatal drug exposure could potentially improve benefit-risk evaluation. In this study, we investigated the impact of two functional polymorphisms...
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy [0.03%]
临床药理遗传学实施联盟关于CYP2B6基因型和美沙酮治疗的指南
Katherine M Robinson,Seenae Eum,Zeruesenay Desta et al.
Katherine M Robinson et al.
Methadone is a mu (μ) opioid receptor agonist used clinically in adults and children to manage opioid use disorder, neonatal abstinence syndrome, and acute and chronic pain. It is typically marketed as a racemic mixture of R- and S-enantio...
Influence of CYP2B6 Genotype on Methadone Dosage in Patients from the Methadone Maintenance Treatment (MMT) Program in Pereira, Colombia [0.03%]
哥伦比亚佩雷拉美沙酮维持治疗患者的CYP2B6基因型对美沙酮剂量的影响研究
Carlos Isaza,Oscar Mauricio Castaño-Ramírez,Juan Pablo Vélez et al.
Carlos Isaza et al.
Methadone treatment reduces the use of heroin and withdrawal symptoms; however, methadone is an expensive medication with a narrow safety margin. We compared the retention rates, persistence of heroin use, and quality of life of a group of ...
Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants [0.03%]
基于生理的药代动力学模型确定CYP2B6基因型对儿童、母亲和母乳喂养婴儿中的依法韦浓度的影响
Xian Pan,Karen Rowland Yeo
Xian Pan
The antiretroviral drug efavirenz remains widely used in children and mothers during breastfeeding in tuberculosis-endemic areas. Evaluating the safety of efavirenz during breastfeeding requires an understanding of its pharmacokinetics (PKs...
Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study [0.03%]
乌干达高病毒血症的艾滋病毒感染产妇中的CYP2B6基因型与依非韦伦耐药性：巢式横断面研究
Allan Buzibye,Kara Wools-Kaloustian,Adeniyi Olagunju et al.
Allan Buzibye et al.
Background: We investigated the association between CYP2B6 polymorphisms and efavirenz drug resistance among women living with HIV who started on antiretroviral therapy during pregnancy and with high viremia during post-p...
CYP3A and CYP2B6 Genotype Predicts Glucose Metabolism Disorder among HIV Patients on Long-Term Efavirenz-Based ART: A Case-Control Study [0.03%]
基于依非韦伦的抗病毒治疗艾滋病患者糖代谢紊乱的病例对照研究及CYP3A和CYP2B6基因多态性的影响预测作用分析
Wondmagegn Tamiru Tadesse,Eulambius Mathias Mlugu,Workineh Shibeshi et al.
Wondmagegn Tamiru Tadesse et al.
Long-term antiretroviral treatment (cART) increases the risk of glucose metabolism disorders (GMDs). Genetic variation in drug-metabolizing enzymes and transporters may influence susceptibility to cART-associated GMDs. We conducted a case-c...
Corrigendum to: CYP2B6 Genotype and Weight Gain Differences Between Dolutegravir and Efavirenz [0.03%]
对CYP2B6基因型和拉替拉韦与依非韦伦体重变化差异的更正注释
Rulan Griesel,Gary Maartens,Maxwell Chirehwa et al.
Rulan Griesel et al.
Impact of CYP2B6 genotype, tuberculosis therapy, and formulation on efavirenz pharmacokinetics in infants and children under 40 months of age [0.03%]
CYC2B6基因型，结核病治疗和剂型对小于40月龄的婴儿和儿童依非韦伦药代动力学的影响
Mina Nikanjam,Lana Tran,Ellen G Chadwick et al.
Mina Nikanjam et al.
Objective: Dosing efavirenz (EFV) in children less than 3 years of age is challenging due to large variability in drug levels. This study evaluated differences in pharmacokinetics with tuberculosis (TB) therapy, formulati...
CYP2B6 Genotype and Weight Gain Differences Between Dolutegravir and Efavirenz [0.03%]
CYP2B6基因型与多替拉韦和依非韦伦之间的体重增加差异
Rulan Griesel,Gary Maartens,Maxwell Chirehwa et al.
Rulan Griesel et al.
Background: Dolutegravir is associated with more weight gain than efavirenz. Loss-of-function polymorphisms in CYP2B6 result in higher efavirenz concentrations, which we hypothesized would impair weight gain among people ...
Retention of polybrominated diphenyl ethers and hydroxylated metabolites in paired human serum and milk in relation to CYP2B6 genotype [0.03%]
CYP2B6基因型受试者人乳和血清中多溴二苯醚及其羟基代谢物的蓄积研究
Deena M Butryn,Lai-Har Chi,Michael S Gross et al.
Deena M Butryn et al.
Polybrominated diphenyl ethers (PBDEs) and their hydroxylated metabolites (OH-BDEs) are endocrine disrupting compounds prevalent in human serum and breast milk. Retention of PBDEs and OH-BDEs in humans may be affected by differences in PBDE...
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