CRISPR/Cas9-Mediated Overexpression of HGF Potentiates Tarim Red Deer Antler MSCs into Osteogenic Differentiation [0.03%]
CRISPR/Cas9介导的HGF过表达促进塔里木马鹿角基质细胞成骨分化
Yujiao Qi,Xiaodong Jia,Chuan Lin et al.
Yujiao Qi et al.
Previous studies conducted by our research groups have demonstrated that the HGF/c-Met signaling pathway promotes the proliferation and migration of MSCs in the antlers of Tarim red deer. However, the role and mechanism of this gene in the ...
CRISPR/Cas9 TCR-Edited NKp30 CAR T Cells Exhibit Superior Anti-Tumor Immunity to B7H6-Expressing Leukemia and Melanoma [0.03%]
CRISPR/Cas9编辑的TCR-NKp30 CAR T细胞对B7H6阳性白血病和黑色素瘤具有更好的抗肿瘤作用
Sedigheh Givi,Benedikt J Lohnes,Saber Ebrahimi et al.
Sedigheh Givi et al.
Chimeric antigen receptor (CAR) T-cell therapy directed to CD19 and B-cell maturation antigen has revolutionized treatment of B-cell leukemia and lymphoma, and multiple myeloma. However, identifying suitable targets for acute myeloid leukem...
CRISPR/Cas9-Mediated TARDBP Knockout Reduces Triacylglycerol Content and Key Milk Fat Metabolism Gene Expression in MAC-T Cells [0.03%]
基于CRISPR/Cas9的TARDBP基因敲除降低MAC-T细胞三酰甘油含量和关键乳脂肪代谢基因表达的研究
Yaran Zhang,Qinglan Zhang,Yaping Gao et al.
Yaran Zhang et al.
TARDBP mediates milk fat secretion in mice by binding to UG-rich sequences in the 3' untranslated region (UTR) of BTN1A1 and XDH mRNA and enhancing their mRNA stability. However, its role in bovine milk lipid metabolism remains unclear. To ...
Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice [0.03%]
利用定制的CRISPR-Cas9碱基编辑器治疗小鼠重度血管疾病的研究
Christiano R R Alves,Sabyasachi Das,Vijai Krishnan et al.
Christiano R R Alves et al.
Pathogenic missense mutations in the alpha actin isotype 2 (ACTA2) gene cause multisystemic smooth muscle dysfunction syndrome (MSMDS), a genetic vasculopathy that is associated with stroke, aortic dissection and death in childhood. Here we...
Potential of recombinant avian adeno-associated virus as a viral vector for CRISPR/Cas9 delivery to avian cells [0.03%]
重组禽腺相关病毒作为CRISPR / Cas9载体递送至禽细胞的潜能
Takumi Terada,Sodai Fujii,Nanako Yamanishi et al.
Takumi Terada et al.
While genome editing has been established in chickens, where cultured primordial germ cell (PGC) systems are available, the implementation of genome editing remains a major challenge in many other birds due to the lack of robust PGC culture...
Stem cell and CRISPR/Cas9 gene editing technology in Alzheimer's disease therapy: from basic research to clinical innovation [0.03%]
阿尔茨海默病治疗中的干细胞和CRISPR/Cas9基因编辑技术：从基础研究到临床创新
Cong He,Baojiang Chen,Ciai Yan et al.
Cong He et al.
Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by Aβ plaques, tau protein neuronal fiber tangles, and neuroinflammation, poses a significant global health problem, and current therapies focus on the sympto...
CRISPR/Cas9-mediated editing of COQ4 in induced pluripotent stem cells: A model for investigating COQ4-associated human coenzyme Q10 deficiency [0.03%]
基于COQ4基因 iPSC 的 CRISPR/Cas9 基因编辑：建立人类辅酶 Q10 缺乏症模型
Sonja Herbrich,Haribaskar Ramachandran,Annette Seibt et al.
Sonja Herbrich et al.
Pathogenic variants in the gene COQ4 cause primary coenzyme Q10 deficiency, which is associated with symptoms ranging from early epileptic encephalopathy up to adult-onset ataxia-spasticity spectrum disease. We genetically modified commerci...
Reduced Susceptibility to Phytophthora in Non-Transgenic Cacao Progeny Through CRISPR-Cas9 Mediated TcNPR3 Mutagenesis [0.03%]
通过CRISPR-Cas9介导的TcNPR3突变降低非转基因可可后代对疫病霉菌的敏感性
Mark J Guiltinan,Lena Landherr,Siela N Maximova et al.
Mark J Guiltinan et al.
Black pod disease, caused by a complex of Phytophthora species, poses a severe threat to global cacao production. This study explores the use of CRISPR-Cas9 genome editing to reduce disease susceptibility in Theobroma cacao L. by targeting ...
Correction: CRISPR/Cas9 editing of CBP80 enhances drought tolerance in potato (Solanum tuberosum) [0.03%]
CRISPR/Cas9编辑CBP80可增强马铃薯的抗旱性(Solanum tuberosum) corrections
C A Decima Oneto,G A Massa,L Echarte et al.
C A Decima Oneto et al.
[This corrects the article DOI: 10.3389/fpls.2025.1598947.]. Keywords: abiotic stress; abscisic acid; cap bi...
Published Erratum
Frontiers in plant science. 2025 Aug 22:16:1674362. DOI:10.3389/fpls.2025.1674362 2025
Multiple Lignocellulosic Inhibitor-Tolerant Saccharomyces cerevisiae Strains Developed by Evolutionary Engineering and CRISPR/Cas9 Gene Editing Technology [0.03%]
利用进化工程和CRISPR/Cas9基因编辑技术获得的多种耐 lignocellulose 抑制剂酿酒酵母菌株
Guangyu Chen,Yule Shan,Jiao Wang et al.
Guangyu Chen et al.
Through evolutionary engineering strategies, scientists have successfully cultivated multiple strains of Saccharomyces cerevisiae with enhanced tolerance, demonstrating significant potential in improving S. cerevisiae resistance. In this st...
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