Distribution of Genetic Determinants Associated with CRISPR-Cas Systems and Resistance to Antibiotics in the Genomes of Archaea and Bacteria [0.03%]
古菌和细菌基因组中与CRISPR-Cas系统及抗生素抗性相关的遗传决定因子的分布
Laura Antequera-Zambrano,Ángel Parra-Sánchez,Lenin González-Paz et al.
Laura Antequera-Zambrano et al.
The CRISPR-Cas system represents an adaptive immune mechanism found across diverse Archaea and Bacteria, allowing them to defend against invading genetic elements such as viruses and plasmids. Despite its broad distribution, the prevalence ...
SELECT: high-precision genome editing strategy via integration of CRISPR-Cas and DNA damage response for cross-species applications [0.03%]
基于CRISPR-Cas和DNA损伤反应的跨物种应用高精度基因组编辑策略SELECT操作符：基于CRISPR-Cas和DNA损伤反应的跨物种应用高精度基因组编辑策略
Xiaohang Liu,Huiping Tan,Junyan Wang et al.
Xiaohang Liu et al.
CRISPR-based methods enable genome modifications for diverse applications but often face challenges, such as inconsistent efficiencies, reduced performance in iterative modifications, and difficulties generating high-quality datasets for hi...
END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes [0.03%]
末端核酸酶：针对多种超修饰噬菌体基因组的抗噬菌体防御系统
Wearn-Xin Yee,Yan-Jiun Lee,Timothy A Klein et al.
Wearn-Xin Yee et al.
Prokaryotes carry clusters of phage defense systems in "defense islands" that have been extensively exploited bioinformatically and experimentally for discovery of immune functions. However, little effort has been dedicated to determining w...
Audrey Leprince,Sylvain Moineau
Audrey Leprince
Bacteria have evolved a wide range of defense systems to combat phage infections. In the cheese industry, lactic acid bacteria (LAB) used for milk fermentation continuously face threats from phages. Therefore, selecting or developing indust...
CRISPR-Cas Dynamics in Carbapenem-Resistant and Carbapenem-Susceptible Klebsiella pneumoniae Clinical Isolates from a Croatian Tertiary Hospital [0.03%]
克罗地亚一家三级医院临床分离的碳青霉烯耐药和敏感肺炎克雷伯菌的CRISPR-Cas动态变化
Ivana Jurić,Marko Jelić,Manda Markanović et al.
Ivana Jurić et al.
(1) Background: CRISPR-Cas systems provide adaptive immunity against mobile genetic elements (MGEs) carrying antimicrobial resistance (AMR) genes. Carbapenem-resistant (CR) Klebsiella pneumoniae is a major public health concern, and the rol...
The Use of CRISPR-Cas Systems for Viral Detection: A Bibliometric Analysis and Systematic Review [0.03%]
用于病毒检测的CRISPR-Cas系统 bibliometric分析和系统综述
Othmane Jeddoub,Nadia Touil,Omar Nyabi et al.
Othmane Jeddoub et al.
Viral infections impose a significant burden on global public health and the economy. This study examines the current state of CRISPR-Cas system research, focusing on their applications in viral detection and their evolution over recent yea...
Artificial Intelligence in CRISPR-Cas Systems: A Review of Tool Applications [0.03%]
基于CRISPR-Cas系统的工具应用人工智能研究进展综述
Srija Khammampalli,Vaibhav Vindal
Srija Khammampalli
Genetic engineering is a method used to alter an organism's DNA, which could entail altering a base pair, removing a section of DNA, or introducing a new DNA segment. Over time, genetic engineering has progressed from basic cloning for rese...
[Development of a miniaturized CRISPR/Cas gene editing tool for human gut Bacteroides] [0.03%]
开发一种用于人类肠道细菌菌的小型CRISPR/Cas基因编辑工具
Yiwen Zhan,Linggang Zheng,Juntao Shen et al.
Yiwen Zhan et al.
: Bacteroides, as one of the most abundant and diverse genera in the human gut, is regarded as a window into the study of gut microbiota-host interactions. Currently, CRISPR/Cas-based gene editing systems targeting Bacteroides have been wid...
Oxidative stress elicited by phage infection induces Staphylococcal type III-A CRISPR-Cas system [0.03%]
由噬菌体感染引起的氧化应激诱导金黄色葡萄球菌III-A型CRISPR-Cas系统
Yang Li,Changbin Zhao,Yingqian Cao et al.
Yang Li et al.
In prokaryotes, the CRISPR-Cas system provides immunity to invading mobile genetic elements, but its expression is commonly repressed in the absence of phage infection to prevent autoimmunity. How bacteria senses phage infection and activat...
Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations [0.03%]
提高特异性、精确性、可及性、灵活性和安全性以克服传统CRISPR/Cas编辑挑战并推动未来创新
Muna Alariqi,Mohamed Ramadan,Lu Yu et al.
Muna Alariqi et al.
Derived from the bacterial immune system, CRISPR/Cas9 induces DSBs at specific DNA sequences, which are repaired by the cell's endogenous mechanisms, leading to gene insertions, deletions, or substitutions. Despite its transformative potent...
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