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Nadia Leen,Antoin de Weijer,Marco Boks et al. Nadia Leen et al.
Background: During military deployment, stress regulation is vital to protect against the development of anxiety and trauma-related symptoms. Brain endocannabinoids play an important role in stress regulation and previous...
Wenping Zhao,Qi Lan,Mingzhu Zhou et al. Wenping Zhao et al.
Corticotropin-releasing hormone receptor 1 (CRHR1), a hormone receptor essential to the activation of HPA axis and the subsequent release of cortisol, plays critical roles in emotional and behavioral responses relevant to attachment. Howeve...
Malek Zihlif,Osama H Abusara,Walid Al-Qerem et al. Malek Zihlif et al.
Objectives: Rhinitis is classified into several types with allergic rhinitis (AR) being the most common. AR is among the inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), in which cor...
Nenad Jaksic,Emina Šabić Džananović,Branka Aukst Margetic et al. Nenad Jaksic et al.
Background: Posttraumatic stress disorder (PTSD) is a highly frequent and disabling psychiatric condition among war-affected populations. The FK506-binding protein 5 (FKBP5) gene and the corticotropin-releasing hormone re...
Birgit Ludwig,Klemens Kienesberger,Laura Carlberg et al. Birgit Ludwig et al.
Background: Previous studies have shown that the hypothalamus-pituitary-adrenal-axis (HPA-axis) is closely involved in the development of affective disorders. Given that early life events are also linked to dysregulation of the same system,...
Jared Lessard,E Alison Holman Jared Lessard
Objective: Stressful life events experienced during childhood and as an adult negatively impact mental and physical health over the life span. This study examined polymorphisms from 2 hypothalamic-pituitary-adrenal axis-r...
Jessica Ezzell Hunter,Mary Leslie,Gloria Novak et al. Jessica Ezzell Hunter et al.
The fragile X mental retardation gene, FMR1, contains a polymorphic CGG repeat in the 5'-untranslated region of exon 1. Once unstable, this repeat is capable of expansion across generations. Women who carry a premutation allele (55-199 repe...
Neeraj Sharma,Shally Awasthi,Subha R Phadke et al. Neeraj Sharma et al.
Aims: With the rapid advances in molecular techniques, various methods for genotyping single-nucleotide polymorphisms (SNPs) are available. Still, the search for easy, robust, and less costly techniques continues. We wish...
Woo J Kim,Seung S Sheen,Tae-Hyung Kim et al. Woo J Kim et al.
Background and objective: Inhaled corticosteroids are used to treat COPD and asthma. An association between sequence variants in the corticotrophin-releasing hormone receptor 1 (CRHR1) gene and improved lung function in a...
Terreia S Jones,Sue C Kaste,Wei Liu et al. Terreia S Jones et al.
Purpose: Corticosteroids are a critical component of therapy for acute lymphoblastic leukemia (ALL) but are associated with late effects, such as osteoporosis. Risk factors remain poorly defined. Because CRHR1 polymorphis...
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