High expression of CCL3/CCL4/CCL5/CCR5 promotes exhausted CD8+ T cells terminal differentiation and is associated with poor prognosis in pediatric B-ALL patients [0.03%]
CCL3/CCL4/CCL5/CCR5高表达促进儿童B-急淋患者耗竭性CD8+T细胞向终末分化并与预后不良相关
Jiamian Zheng,Yupei Zhang,Xueting Peng et al.
Jiamian Zheng et al.
This study aims to identify differentially upregulated ligand-receptor interactions between B-ALL cells and exhausted CD8+ T cells and to develop a multivariate Cox regression model for predicting the overall survival of pediatric B-ALL pat...
Immunogenomic characteristics and prognostic implications of terminally exhausted CD8+ T cells in colorectal cancers [0.03%]
结直肠癌中终末耗竭CD8+T细胞的免疫组学特征及其预后意义
Ji-Ae Lee,Hye Eun Park,Dae-Won Lee et al.
Ji-Ae Lee et al.
Introduction: T-cell exhaustion is a major mechanism of immune evasion. Recently, the therapeutic and prognostic implications of progenitor exhausted T cells (Tpex) and terminally exhausted T cells (Ttex) have been explor...
Blocking Tim-3 enhances CD8+ T cell activity to inhibit hepatocellular carcinoma recurrence post-radiofrequency ablation [0.03%]
阻断Tim-3可增强CD8+T细胞活性以抑制射频消融后肝癌复发
Na Wu,Xinru Pei,Weiguo Cai et al.
Na Wu et al.
Background: Incomplete radiofrequency ablation (iRFA) for hepatocellular carcinoma (HCC) during radiofrequency ablation (RFA) may result in rapid progression of residual tumors and resistance to anti-PD-1 therapy. Researc...
Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27 [0.03%]
HLA-B27介导的人类白细胞抗原-B27相关脊柱关节炎中NKG2C+CD8+T细胞增龄相关的增强胞毒作用机制研究
Kunhai Tang,Xiaobei Ma,Jian Gao et al.
Kunhai Tang et al.
Background: This study aims to explore the common mechanisms between aging and the pathogenesis of ankylosing spondylitis (AS) and to identify potential therapeutic targets. ...
Identification of biomarkers associated with exhausted CD8 + T cells in the tumor microenvironment of intrahepatic cholangiocarcinoma based on Mendelian randomization and bioinformatics analysis [0.03%]
基于孟德尔随机化和生物信息学分析鉴定与肿瘤微环境中耗竭性CD8⁺T细胞相关的生物标志物
LiuXing Feng,Quan Yuan,Hao Yu et al.
LiuXing Feng et al.
Intrahepatic cholangiocarcinoma (iCCA) represents a growing health concern due to its increasing incidence and poor prognosis, highlighting the urgent need for biomarkers and therapeutic targets. This study utilized BayesPrism deconvolution...
Regulatory T cells define affinity thresholds for CD8+ T cell tumor infiltration [0.03%]
调节性T细胞确定CD8+t细胞肿瘤浸润的亲和力阈值
Mona O Mohsen,Romano Josi,Sanjana V Marar et al.
Mona O Mohsen et al.
TCR repertoires against tumors lack high-affinity TCRs and are further suppressed by Tregs. We hypothesized that Treg depletion enhances the antitumor efficacy of low-affinity T cells. Using the weak agonistic peptide A4Y derived from LCMV ...
Antiangiogenic therapy combined with immune checkpoint blockade mediates CCR7+CD8+ T-cell entry into HCC through high endothelial venules [0.03%]
抗血管生成与免疫检查点抑制剂联合治疗可促进CCR7+CD8+T细胞通过高内皮微静脉进入肝癌组织
Lu Tang,Yingwen Hou,Tian Di et al.
Lu Tang et al.
Background aims: Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality in China. Anti-angiogenic drugs (AADs) plus immune checkpoint blockade (ICB) combination therapy shows considerable promise for H...
SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway [0.03%]
SLC4A10通过MAPK通路抑制CD8⁺T细胞IFN-γ/GZMB水平而妨碍动脉粥样硬化形成
Bo Chen,Lei Zhu,Xueguang Lin et al.
Bo Chen et al.
Background and aims: CD8+ T cell subpopulations participate in the formation of atherosclerotic plaques through activation or exhaustion. Yet, it is unclear which specific subset it critically involved. The SLC4A10+ CD8+ ...
Marina Seady,Aaron J Johnson
Marina Seady
Blood-brain barrier (BBB) disruption is a hallmark of many neurological diseases. It is known that proinflammatory cytokines can disrupt tight junctions between endothelial cells of the BBB, allowing larger molecules to penetrate the brain....
Generation and functional analysis of melanoma antigen-specific CD8+ T cells derived from S/MAR vector-transfected human induced pluripotent stem cells [0.03%]
由S/MAR载体转染的人诱导多能干细胞衍生的黑色素瘤抗原特异性CD8+t细胞的生成及功能分析
Juliane Poelchen,Sandra Pardo,Daniel Novak et al.
Juliane Poelchen et al.
Melanoma accounts for the majority of all skin cancer-related deaths with rising incidence rates. Adoptive cell therapies (ACT) with tumor antigen-specific CD8+ T cells derived from human-induced pluripotent stem cells (hiPSCs) might offer ...
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