Jingjing Chen,Xiaoming Wang
Jingjing Chen
The maintenance of peripheral tolerance depends on various regulatory mechanisms. Thus, the breakdown of self-tolerance leads to the development of autoimmunity. Although the pathogenesis of autoimmune diseases is complex, they are primaril...
Convergence and divergence of B cell responses in two HIV-1 Env immunizations in Rhesus macaques [0.03%]
两种HIV-1包膜免疫在恒河猴B细胞反应的汇聚和发散
Jenna M DeLuca,Maria Blasi,Taylor J McGee et al.
Jenna M DeLuca et al.
Background: Sequential multivalent immunizations are used to counter diversity in rapidly mutating viruses. Here, we evaluated the effect of HIV-1 immunogen formats on the binding profile of memory B-cells elicited in two...
Li Y Drake,Kimberly E Stelzig,Ana M Hernandez-Botero et al.
Li Y Drake et al.
Introduction: Asthma demonstrates a strong sex bias. B cells play critical roles in the pathogenesis of allergic inflammation, including allergen-specific immunoglobulin production. The sex-specific responses of B cell su...
Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses [0.03%]
狼疮淋巴管功能障碍导致皮肤光敏感和淋巴结B细胞反应
Mir J Howlader,William G Ambler,Madhavi Latha S Chalasani et al.
Mir J Howlader et al.
Patients with systemic lupus erythematosus (SLE) are photosensitive, developing skin inflammation with even ambient ultraviolet radiation (UVR), and this cutaneous photosensitivity can be associated with UVR-induced flares of systemic disea...
BA.1 breakthrough infection elicits distinct antibody and memory B cell responses in vaccinated-only versus hybrid immunity individuals [0.03%]
疫苗接种者和杂交免疫者对抗BA.1的抗体和记忆B细胞反应的差异性
Carla Saade,Timothée Bruel,Lou-Léna Vrignaud et al.
Carla Saade et al.
Immune memory is influenced by the frequency and type of antigenic challenges. Here, we performed a cross-sectional comparison of immune parameters following a BA.1 breakthrough infection in individuals with prior hybrid immunity (conferred...
Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infection [0.03%]
表型异质性通过疫苗和感染的重复暴露定义B细胞对SARS-CoV-2的反应
Lela Kardava,James Lim,Clarisa M Buckner et al.
Lela Kardava et al.
Long-lived humoral memory is key to durable immunity against pathogens yet remains challenging to define due to heterogeneity among antigen-reactive B cells. We addressed this gap through longitudinal sampling over the course of severe acut...
Coordinated Regulation of Extrafollicular B Cell Responses by IL-12 and IFNγ [0.03%]
IL-12和IFNγ对额外滤泡B细胞反应的协同调节作用
Rebecca A Elsner,Mark J Shlomchik
Rebecca A Elsner
Upon activation, B cells undergo either the germinal center (GC) or extrafollicular (EF) response. While GC are known to generate high-affinity memory B cells and long-lived plasma cells, the role of the EF response is less well understood....
Recall vaccination increases detectable B-cell reactivity in persons with multiple sclerosis treated with ocrelizumab [0.03%]
加强免疫接种可增加奥瑞珠单抗治疗的多发性硬化症患者体内B细胞反应性
Lucia Moiola,Alessandra Mandelli,Maciej Tarkowski et al.
Lucia Moiola et al.
Background: Utility of repeated boosts of anti-SARS-CoV-2 vaccination in persons with MS (pwMS) treated with ocrelizumab is questioned. Objective: ...
Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic [0.03%]
新冠疫情暴发三年后SARS-CoV-2的抗体B细胞反应可持续多年
Luis M Molinos-Albert,Rocío Rubio,Carla Martín-Pérez et al.
Luis M Molinos-Albert et al.
Immune memory is essential for the effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. In the current context of the pandemic, with a diminished vaccine efficacy against emerging variants, it remains c...
Minor Splicing Factor RNPC3 Is Essential for the Germinal Center B Cell Response [0.03%]
次要剪接因子RNPC3对生发中心B细胞反应是必不可少的
Jing Wang,Gui-Xin Ruan,Yuxing Li et al.
Jing Wang et al.
Germinal center (GC) response ensures the generation of diverse and high-affinity antibodies during the T cell-dependent (TD) immune response. This process is controlled by coordinated transcriptional and posttranscriptional gene regulatory...
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