TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy [0.03%]
用于多柔比星致肾病的超声引导诊疗的特异性靶向TRPC6的糖皮质激素纳米气泡
Lin Wu,Yang Liu,Ziqi Fu et al.
Lin Wu et al.
Background: Glucocorticoid (GC) intolerance and systemic toxicity pose significant challenges in the treatment of primary nephrotic syndrome (PNS), underscoring the urgent need for targeted therapies that maximize efficac...
Brain peptides modified exosome-mediated drug delivery system for adriamycin-induced nephropathy treatment [0.03%]
脑肽修饰的外泌体介导的阿霉素肾病治疗递药系统
Lishan Tan,Huisong Zhou,Zhiwei Lai et al.
Lishan Tan et al.
Mitigation of adriamycin (ADR)-induced nephropathy remains a significant challenge in clinical management. Brain-targeted administration of losartan demonstrates comparable nephroprotective effects at a 1:500 concentration relative to gavag...
NAT10 mediates TLR2 to promote podocyte senescence in adriamycin-induced nephropathy [0.03%]
NAT10介导TLR2促进阿霉素诱导的肾病中足细胞衰老
Mingyang Hu,Linxiao Lv,Yuqi Lei et al.
Mingyang Hu et al.
N-acetyltransferase 10 (NAT10) is involved in regulating senescence. However, its role in glomerular diseases remains unclear. Therefore, this study aims to investigate the mechanisms by which NAT10 influences senescence and damage in an ad...
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy [0.03%]
烟酰胺改善了阿霉素诱导的肾病中的足细胞损伤和蛋白尿
Kei Takahashi,Emiko Sato,Seiko Yamakoshi et al.
Kei Takahashi et al.
Podocytes are key components of the glomerular filtration barrier, and their injury leads to proteinuria, chronic kidney disease (CKD), and nephrotic syndrome. Effective treatments for these conditions are not well established, and preventi...
SA4503 Mitigates Adriamycin-Induced Nephropathy via Sigma-1 Receptor in Animal and Cell-Based Models [0.03%]
SA4503通过Sigma-1受体在动物和细胞模型中减轻阿霉素诱导的肾病
Hideaki Tagashira,Shinsuke Chida,Md Shenuarin Bhuiyan et al.
Hideaki Tagashira et al.
Background/Objectives: The Sigma-1 receptor (Sigmar1), an intracellular chaperone protein, is ubiquitously expressed throughout the body, but its role in peripheral organs, such as the kidneys, remains unclear. Here, we investigated the pro...
Plantaginis Herba attenuates adriamycin-induced nephropathy: Molecular mechanism insights by integrated transcriptomic and experimental validation [0.03%]
丹参防治阿霉素肾病的机制研究：整合转录组和实验验证
Beibei Zhang,Mengnan Zeng,Ru Wang et al.
Beibei Zhang et al.
Ethnopharmacological relevance: The Chinese herbal Plantaginis Herba (PL) is one of the most widely used plants for both medicinal and dietary purposes. Plantaginis Herba is the main medicine used in a traditional Chinese...
Rostellularia procumbens (L) Nees. extract attenuates adriamycin-induced nephropathy by maintaining mitochondrial dynamics balance via SIRT1/PGC-1α signaling pathway activation [0.03%]
通过激活SIRT1/PGC-1α信号通路维持线粒体动力学平衡百喜草提取物对阿霉素肾病的保护作用
Zhongzhu Ai,Dongfeng Yuan,Ruotong Dong et al.
Zhongzhu Ai et al.
Ethnopharmacological relevance: Rostellularia procumbens (L) Nees. (R. procumbens) is a classical Chinese herbal medicine that has been used for effective treatment of kidney disease for nearly a thousand years in China. ...
Stem Cells Derived From Human Deciduous Exfoliated Teeth Ameliorate Adriamycin-Induced Nephropathy In Rats By Modulating The Th17/Treg Balance [0.03%]
人乳牙干细胞通过调节Th17/Treg平衡来改善阿霉素诱导的大鼠肾病
Yuyang Dai,Borui Tang,Xiuli Zhao
Yuyang Dai
Objective: This study aimed to explore the therapeutic potential of stem cells derived from human exfoliated deciduous teeth (SHEDs) in INS using an adriamycin-induced nephropathy (AN) rat model.
Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin-Induced Nephropathy Model Rat by 1H NMR and MS-Based Untargeted Metabolomics Analysis [0.03%]
基于~(1)H NMR和非靶向代谢组学的MS分析 investigation into潜在的物质基础与机制英文标题翻译成中文：黄芪抗阿霉素致肾病模型大鼠的作用及潜在的物质基础与机制研究
Aiping Li,Ben Li,Ting Cui et al.
Aiping Li et al.
Astragali Radix (AR) is one of the monarch drugs of Fangji Huangqi decoction and has the effects of inducing diuresis to alleviate edema, tonifying and strengthening the body. However, there is a paucity of research regarding the effective ...
Adriamycin-induced nephropathy models: elucidating CKD pathophysiology and advancing therapeutic strategies [0.03%]
阿霉素肾病模型：阐明CKD发病机制及推进治疗策略
Masaki Watanabe,Hayato R Takimoto,Nobuya Sasaki
Masaki Watanabe
The Adriamycin-induced nephropathy (AN) model plays a crucial role in advancing our understanding of and research on chronic kidney disease (CKD). This review outlines methodologies for generating AN models in mice and rats, discusses their...
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