An alternative mechanism by which If1 prevents ATP hydrolysis by the ATP synthase subcomplex in S. cerevisiae [0.03%]
酿酒酵母中If1通过另一种机制防止ATP合酶亚复合物发生ATP水解反应
Orane Lerouley,Isabelle Larrieu,Tom Louis Ducrocq et al.
Orane Lerouley et al.
The mitochondrial F1F0-ATP synthase is crucial for maintaining the ATP/ADP balance which is critical for cell metabolism, ion homeostasis and cell proliferation. This enzyme, conserved across evolution, is found in the mitochondria or chlor...
Showing the Bonds-A Subtle but Important Difference in Figure Design that May Alleviate Student Confusion about ATP Hydrolysis [0.03%]
展示键的差异——图设计中一个微妙但重要的不同可能有助于缓解学生对ATP水解的困惑
Crystal Uminski,Shreya Sujith,Aneesh Nallani et al.
Crystal Uminski et al.
A misconception among biology students is that breaking bonds in adenosine triphosphate (ATP) releases energy. This misconception may be related to imprecise representations of chemical bonding in common diagrams of ATP hydrolysis. We inter...
Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain [0.03%]
BiP的Hsp70二聚体结合结构域的ATP水解机制
Guillaume Mas,Sebastian Hiller
Guillaume Mas
The 70 kDa heat shock protein (Hsp70) family of molecular chaperones ensures protein biogenesis and homeostasis, driven by ATP hydrolysis. Here, we introduce in-cyclo NMR, an experimental setup that combines high-resolution NMR spectroscopy...
BLF1 Affects ATP Hydrolysis Catalyzed by Native and Mutated eIF4A1 and eIF4A2 Proteins [0.03%]
BLF1影响eIF4A1和eIF4A2野生及突变型蛋白催化的ATP水解反应
Min An,Xin Cheng,Yu Zhang et al.
Min An et al.
Burkholderia lethal factor 1 (BLF1), a toxin derived from Burkholderia pseudomallei, reacts with eukaryotic initiation factor (eIF) 4A to inhibit protein synthesis. eIF4A1 and eIF4A2 are involved in translation initiation and share over 90%...
Symmetric stimulation of Hsp90 catalyzed ATP hydrolysis through enhanced active site gate dynamics [0.03%]
通过增强活性位点门动力学对Hsp90催化的ATP水解进行对称刺激
Breanna Magnan,Thomas Dumont,Suad Rashid et al.
Breanna Magnan et al.
Heat shock protein 90 (Hsp90) is a vital molecular chaperone that is essential for activating a diverse array of regulatory proteins through an ATP-dependent clamping cycle. The Hsp90 clamping cycle is driven by large-amplitude conformation...
Solution AFM imaging and coarse-grained molecular modeling of yeast condensin structural variation coupled to the ATP hydrolysis cycle [0.03%]
酵母凝聚素结构变异的溶液AFM成像及与ATP水解周期耦合的粗粒分子建模
Hiroki Koide,Noriyuki Kodera,Shoji Takada et al.
Hiroki Koide et al.
Condensin is a protein complex that regulates chromatin structural changes during mitosis. It varies the molecular conformation through the ATP hydrolysis cycle and extrudes DNA loops into its ring-like structure as a molecular motor. Conde...
In vivo nucleotide excision repair by mycobacterial UvrD1 requires ATP hydrolysis but does not depend on cysteine disulfide-mediated dimerization and DNA unwinding [0.03%]
支原体UvrD1在体内的核苷酸切除修复需要ATP水解，但不需要半胱氨酸二硫化物介导的二聚化和DNA解旋功能
Garrett M Warren,Stewart Shuman
Garrett M Warren
Mycobacterial UvrD1 is an SF1-type ATPase that participates in nucleotide excision repair (NER). UvrD1 consists of N-terminal ATPase and C-terminal Tudor domains. The monomeric UvrD1 characterized originally displays vigorous DNA-dependent ...
Structural insights into chromatin remodeling by ISWI during active ATP hydrolysis [0.03%]
ISWI染色质重塑过程中ATP水解活跃时期的结构见解
Youyang Sia,Han Pan,Kangjing Chen et al.
Youyang Sia et al.
Chromatin remodelers utilize the energy of adenosine triphosphate (ATP) hydrolysis to slide nucleosomes, regulating chromatin structure and gene activity in cells. In this work, we report structures of imitation switch (ISWI) bound to the n...
Dynamic conformations of the P. furiosus MR-DNA complex link Mre11 nuclease activity to DNA-stimulated Rad50 ATP hydrolysis [0.03%]
Pyrococcus furiosus MR-DNA复合物的动态构象将Mre11核酸酶活性与DNA刺激的Rad50 ATP水解联系起来
Marella D Canny,Mahtab Beikzadeh,Navneet Kaur et al.
Marella D Canny et al.
The MRE11-RAD50-NBS1/Xrs2 (MRN/X) protein complex has essential roles in the repair of damaged DNA. The current understanding of the conformational landscape of the core MR complex comes from various structural studies. However, given the h...
Visual representations of energy and chemical bonding in biology and chemistry textbooks: A case study of ATP hydrolysis [0.03%]
生物和化学教科书中能量和化学键的可视化表示：以ATP水解为例的研究
Mingyu Yang,Bryan C Armpriest,L Kate Wright et al.
Mingyu Yang et al.
Energy is a crosscutting concept in science, but college students often perceive a mismatch between how their biology and chemistry courses discuss the topic. The challenge of reconciling these disciplinary differences can promote faulty re...
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