Polygonatum sibiricum polysaccharide ameliorates neurotoxicity in Alzheimer disease mice by inhibiting endoplasmic reticulum stress and lipid raft formation through AMPK/GSK3β/Nrf2 pathway [0.03%]
Polygonatum sibiricum多糖通过AMPK/GSK3β/Nrf2信号通路抑制内质网应激和脂筏形成缓解阿尔茨海默病小鼠神经毒性作用
Shixing Wu,Wei Liu,Changying Zhang
Shixing Wu
Background: Polygonatum sibiricum polysaccharide (PSP) is known for its anti-inflammatory and cognitive improvement effects. However, its potential to alleviate neurotoxicity in Alzheimer's diseafse (AD) has not been thor...
OTUD1 inhibits macrophage ferroptosis via regulation of AMPK and GSK3β/β-catenin signaling pathways exerting protective effects in sepsis-induced acute lung injury [0.03%]
溶酶体Cathepsin B通过激活AMPK和GSK3β/β-catenin信号通路抑制巨噬细胞铁死亡从而在脓毒症诱导的急性肺损伤中发挥保护作用
Qian Wang,Huifan Liu,Min Yuan et al.
Qian Wang et al.
Sepsis is a life-threatening organ dysfunction caused by dysregulated inflammatory and immune responses to infection. Its global incidence and mortality remain high, posing a severe threat to public health. Acute lung injury (ALI) is a comm...
Norboldine improves cognitive impairment and pathological features in Alzheimer's disease by activating AMPK/GSK3β/Nrf2 signaling pathway [0.03%]
norboldine通过激活ampk/gsk3β/nrf2信号通路改善阿尔茨海默病的认知障碍和病理特征
Yuqing Zeng,Li Xiong,Hao Tang et al.
Yuqing Zeng et al.
Ethnopharmacological relevance: Lindera aggregata (Sims) Kosterm is a common traditional herb that has multiple bioactivities. Radix Linderae (LR), the dry roots of Lindera aggregata (Sims) Kosterm, is a traditional Chine...
Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway [0.03%]
通过调节AMPK/GSK3β(丝氨酸9)/Nrf2信号通路缓解认知功能障碍和神经毒性的作用机制研究
Jinfeng Sun,Liwei Li,Li Xiong et al.
Jinfeng Sun et al.
Alzheimer's disease (AD) stands as the predominant age-related neurodegenerative disorder, for which efficacious treatment remains elusive. An auspicious avenue for this disease lies in natural compounds sourced from tranditional medicine a...
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling [0.03%]
茶黄素通过调节PKA/LKB1/AMPK/GSK3β信号通路并增强Nrf2信号而抑制肝星状细胞活化
Guangwen Shu,Hui Sun,Tiantian Zhang et al.
Guangwen Shu et al.
Activation of hepatic stellate cells (HSCs) constitutes a crucial etiological factor leading to liver fibrosis. Theaflavine (TF) is a characteristic bioactive compound in fermented tea. Here, we found that TF attenuated the activation of LX...
AMPK targets a proto-oncogene TPD52 (isoform 3) expression and its interaction with LKB1 suppress AMPK-GSK3β signaling axis in prostate cancer [0.03%]
AMPK靶向原癌基因TPD52（异构体3）的表达及其与LKB1的相互作用抑制前列腺癌中的AMPK-GSK3β信号轴
Priyanka Khilar,K K Sruthi,Sakkarai Mohamed Asha Parveen et al.
Priyanka Khilar et al.
Tumor protein D52 (TPD52) is a proto-oncogene overexpressed in prostate cancer (PCa) due to gene amplification and it is involved in the cancer progression of many cancers including PCa. However, the molecular mechanisms underlying the role...
Empagliflozin inhibits excessive autophagy through the AMPK/GSK3β signalling pathway in diabetic cardiomyopathy [0.03%]
恩格列净通过AMPK/GSK3β信号通路抑制糖尿病心肌病中过度的自噬过程
Rosalinda Madonna,Stefania Moscato,Maria Concetta Cufaro et al.
Rosalinda Madonna et al.
Aims: Sodium-glucose cotransporter 2 inhibitors have beneficial effects on heart failure and cardiovascular mortality in diabetic and non-diabetic patients, with unclear mechanisms. Autophagy is a cardioprotective mechani...
Bromelain ameliorates D-galactosamine-induced acute liver injury: role of SIRT1/LKB1/AMPK, GSK3β/Nrf2 and NF-κB p65/TNF-α/caspase-8, -9 signalling pathways [0.03%]
菠萝蛋白酶改善D-半乳糖胺诱导的急性肝损伤：SIRT1/LKB1/AMPK，GSK3β/Nrf2和NF-κB p65/TNF-α/caspase-8，-9信号通路的作用
Manar A Didamoony,Ahmed M Atwa,Enas A Abd El-Haleim et al.
Manar A Didamoony et al.
Objectives: The present research focused on estimating, for the first time, the potential protective effects of bromelain against D-galactosamine-induced acute liver injury in rats as well as identifying the possible unde...
Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK/GSK3β axis [0.03%]
香草素通过激活AMPK/GSK3β轴阻断Nrf2核输出信号保护小鼠肾脏氧化损伤
Bai-Cheng Kuang,Zhi-Heng Wang,Shuai-Heng Hou et al.
Bai-Cheng Kuang et al.
Disrupted redox homeostasis contributes to renal ischemia-reperfusion (IR) injury. Abundant natural products can activate nuclear factor erythroid-2-related factor 2 (Nrf2), thereby providing therapeutic benefits. Methyl eugenol (ME), an an...
CB2R Attenuates Intervertebral Disc Degeneration by Delaying Nucleus Pulposus Cell Senescence through AMPK/GSK3β Pathway [0.03%]
CB2受体通过AMPK/GSK3β信号通路延缓髓核细胞衰老而缓解椎间盘退变
Jiacheng Du,Menglei Xu,Fanchen Kong et al.
Jiacheng Du et al.
Nucleus pulposus (NP) cell (NPC) senescence is one of the main causes of intervertebral disc degeneration (IVDD). However, the underlying mechanism of NPC senescence is still unclear. The cannabinoid type 2 receptor (CB2R) is a member of th...
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