Astrocytic HIF-1α/VEGF induces endothelial PI3K/Akt activation to accelerate post-ischemic angiogenesis upon LCN2 inhibition [0.03%]
LCN2抑制通过星形胶质细胞HIF-1α/VEGF诱导内皮PI3K/Akt活化从而加速缺血后血管新生
Ning Tian,Xiaoxia Li,Yanlin Jiang et al.
Ning Tian et al.
Therapeutic angiogenesis represents a pivotal yet underexplored avenue for functional recovery following cerebral ischemia. Although lipocalin-2 (LCN2) participates in neuropathological processes, its cell-type-specific regulation of post-i...
P2RX4 promotes hepatocellular carcinoma progression via calcium-mediated PI3K/AKT activation and immune remodeling [0.03%]
P2RX4通过钙介导的PI3K/AKT活化和免疫重塑促进肝癌进展
Jianrong Wang,Yanmei Gu,Ze Niu et al.
Jianrong Wang et al.
Background: Hepatocellular carcinoma (HCC) is frequently identified at advanced stages. This constrains therapeutic options and results in poor prognosis. P2RX4 is an ATP-gated ion channel that modulates calcium influx. I...
Dual oncogenic roles of TPD52 and TPD52L2 in gastric cancer progression via PI3K/AKT activation and immunosuppressive microenvironment remodeling [0.03%]
TPD52和TPD52L2通过激活PI3K/AKT和重塑免疫抑制微环境在胃癌进展中的双重致癌作用
Hailong Li,Xiaqing Gao,Shuangming Guo et al.
Hailong Li et al.
Aim: TPD52 (tumor protein D52) and TPD52L2 (tumor protein D52-like 2), members of the TPD52 gene family, have been implicated in multiple malignancies. However, their roles in gastric cancer (GC) remain elusive. Herein, w...
Corrigendum to "SKP2 contributes to AKT activation by ubiquitination degradation of PHLPP1, impedes autophagy, and facilitates the survival of thyroid carcinoma" [Molecules and Cells Volume 46, Issue 6, June 2023, 360-373] [0.03%]
关于“SKP2通过泛素化降解PHLPP1促进Akt激活、抑制自噬并促进甲状腺癌细胞生存”的勘误[Molecules and Cells第46卷，第6期，2023年6月，360-373页]
Yuan Shao,Wanli Ren,Hao Dai et al.
Yuan Shao et al.
Published Erratum
Molecules and cells. 2025 Sep 16:100266. DOI:10.1016/j.mocell.2025.100266 2025
Typhimurium- mediated FAK-AKT activation and lysosome inhibition [0.03%]
订正：巨噬细胞通过下调NEDD9来对抗伤寒沙门氏菌介导的FAK-AKT活化和溶酶体抑制作用
Julia Fischer,Lisa Rusyn,Frederike Krus et al.
Julia Fischer et al.
Published Erratum
Cell death & disease. 2025 Aug 29;16(1):658. DOI:10.1038/s41419-025-07919-z 2025
Puerarin alleviates cerebral ischemia/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K/Akt activation [0.03%]
葛根素通过DNA去甲基化介导的PI3K/Akt激活缓解脑缺血再灌注损伤所致神经元氧化应激和凋亡
Guanfeng Xu,Jie Zhang,Chongyu Shao et al.
Guanfeng Xu et al.
Background: Cerebral ischemia stroke (CIS) is a multifactorial and heterogeneous neurological disorder characterized by high mortality rate and longterm cognitive deficits. Puerarin (Pue) exhibits neuroprotective properti...
Mechanistic Insights into AKT1/GSK3β/CD36 Axis Regulation in ZLY06-Induced Hepatic Lipid Metabolism Dysfunction and Protective Intervention via AKT Activation Strategies [0.03%]
ZLY06诱导的肝脏脂代谢紊乱中AKT1/GSK3β/CD36轴调控机制及Akt激活干预效应研究
Xiaotong Cai,Yuqing Sun,Qin Zhang et al.
Xiaotong Cai et al.
The safety of compounds, particularly hepatotoxicity, is a critical focus in drug development. The novel PPARβ/γ dual agonist ZLY06, a candidate compound for the treatment of metabolic syndrome, exhibited significant hepatotoxic effects i...
FTO-mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer [0.03%]
肺鳞癌中FTO介导的IGFBP3 mRNA去甲基化调控及其对IMP3-P体-AKT信号轴的影响研究
Haiyang Wang,Hui Peng,Zhenzhen Zhang et al.
Haiyang Wang et al.
Lung cancer remains one of the leading causes of cancer-related deaths worldwide, and a growing body of evidence suggests that RNA modifications, including methylation, play a critical role in its progression. In this study, we investigated...
Correction: THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer [0.03%]
纠正：THBS2+癌症相关成纤维细胞通过COL8A1介导的PI3K/AKT活化促进结直肠癌上皮间质转化导致奥沙利铂耐药性
Xing Zhou,Jiashu Han,Anning Zuo et al.
Xing Zhou et al.
Published Erratum
Molecular cancer. 2025 Jun 26;24(1):184. DOI:10.1186/s12943-025-02388-6 2025
Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy [0.03%]
沉默PIM1可抑制ENO1诱导的AKT活化并在脊髓损伤诱发的骨骼肌萎缩期间抑制原纤维形成
Xiao Yu,Jiang Cao,Binyu Wang et al.
Xiao Yu et al.
Spinal cord injury (SCI) induces rapid and extensive skeletal muscle atrophy. During skeletal muscle atrophy, numerous extracellular matrix (ECM) and fibroblasts accumulate, impairing muscle function. The pro-viral Integration site for molo...
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