ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice [0.03%]
ABCA1缺乏导致小鼠SREBP2途径的组织特异性失调
Yoshio Yamauchi,Sumiko Abe-Dohmae,Noriyuki Iwamoto et al.
Yoshio Yamauchi et al.
ABCA1 plays an essential role in the formation of high-density lipoprotein (HDL), and its mutations cause Tangier disease (TD), a familial HDL deficiency. In addition to the disappearance of HDL, TD patients exhibit cholesterol deposition i...
Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids [0.03%]
肝细胞ABCA1缺陷与HDL鞘脂减少有关
Alaa Othman,Mingxia Liu,Heiko Bode et al.
Alaa Othman et al.
ATP binding cassette transporter A1 (ABCA1) limits the formation of high density lipoproteins (HDL) as genetic loss of ABCA1 function causes virtual HDL deficiency in patients with Tangier disease. Mice with a hepatocyte-specific ABCA1 knoc...
Waqas A Malick,Ernst J Schaefer,Robert A Hegele et al.
Waqas A Malick et al.
ATP-binding cassette transporter A1 (ABCA1) deficiency results in very low high-density lipoprotein cholesterol levels. Complete ABCA1 deficiency, or Tangier disease, is characterized by premature atherosclerotic cardiovascular disease, yel...
ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease [0.03%]
ABCA1缺陷通过APE1/IRF1轴促进糖尿病肾病中足细胞焦亡倾向性
Marie Ito,Gloria Michelle Ducasa,Judith David Molina et al.
Marie Ito et al.
Decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution have been described in podocytes in diabetic kidney disease (DKD). To investigate a link between these pathways, ...
Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy [0.03%]
ABCA1缺乏诱发的星形胶质细胞功能障碍导致视神经病变
Youichi Shinozaki,Alex Leung,Kazuhiko Namekata et al.
Youichi Shinozaki et al.
Astrocyte abnormalities have received great attention for their association with various diseases in the brain but not so much in the eye. Recent independent genome-wide association studies of glaucoma, optic neuropathy characterized by ret...
Administration of Downstream ApoE Attenuates the Adverse Effect of Brain ABCA1 Deficiency on Stroke [0.03%]
脑缺ABCA1小鼠模型中APOE下游调控减弱了中风的不良影响
Xiaohui Wang,Rongwen Li,Alex Zacharek et al.
Xiaohui Wang et al.
The ATP-binding cassette transporter member A1 (ABCA1) and apolipoprotein E (ApoE) are major cholesterol transporters that play important roles in cholesterol homeostasis in the brain. Previous research demonstrated that specific deletion o...
Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion [0.03%]
肝ABCA1缺乏与载脂蛋白B分泌转运迟缓及VLDL甘油三酯分泌增加有关
Mingxia Liu,Soonkyu Chung,Gregory S Shelness et al.
Mingxia Liu et al.
ATP binding cassette transporter A1 (ABCA1) is a membrane transporter that facilitates nascent HDL formation. Tangier disease subjects with complete ABCA1 deficiency have
ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice [0.03%]
ABCA1缺乏影响小鼠的基础认知缺陷和树突密度
Nicholas F Fitz,Alexis Y Carter,Victor Tapias et al.
Nicholas F Fitz et al.
ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins and regulates the generation of high density lipoproteins. Previously, we have shown that lack of Abca1 significantly increases amyloid de...
Abca1 deficiency protects the heart against myocardial infarction-induced injury [0.03%]
ABCA1缺陷对心肌梗死所致心脏损伤的保护作用
Mieke C Louwe,Bart Lammers,Miguel A Frias et al.
Mieke C Louwe et al.
Background and aims: We explored the role of ATP-binding cassette transporter A1 (Abca1), in post-myocardial infarction (MI) cardiac injury. Methods: ...
ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice [0.03%]
ABCA1缺乏和细胞胆固醇积累增加小鼠的胰岛淀粉样变性
Nadeeja Wijesekara,Achint Kaur,Clara Westwell-Roper et al.
Nadeeja Wijesekara et al.
Aims/hypothesis: Islet amyloid, a pathological feature of type 2 diabetes, forms from the aggregation of islet amyloid polypeptide (IAPP), a beta cell peptide that is produced and co-secreted with insulin. Cholesterol reg...
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