19F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans [0.03%]
基于19F qNMR的SARSCoV-2-3CL蛋白酶抑制剂simnotrelvir(SIM0417)的人体药代动力学、代谢和物质平衡研究
Ze-Yu Wang,Yong-Mei Ren,Shu-Wei Hu et al.
Ze-Yu Wang et al.
Simnotrelvir (SIM0417), an inhibitor of the 3CL protease of SARS-CoV-2, has been identified as a CYP3A sensitive substrate. This study investigated the pharmacokinetics, metabolism, and mass balance of simnotrelvir following a single oral d...
A 19F-qNMR-Guided Mathematical Model for G Protein-Coupled Receptor Signaling [0.03%]
基于19F-qNMR引导的G蛋白偶联受体信号转导数学模型
Jesús Giraldo,Jesper J Madsen,Xudong Wang et al.
Jesús Giraldo et al.
G protein-coupled receptors (GPCRs) exhibit a wide range of pharmacological efficacies, yet the molecular mechanisms responsible for the differential efficacies in response to various ligands remain poorly understood. This lack of understan...
Multiphase Drug Distribution and Exchange in Oil-in-Water Nanoemulsion Revealed by High-Resolution 19F qNMR [0.03%]
高分辨率19F qNMR揭示油包水型纳米乳剂中药物的多相分布及交换现象
Deyun Wang,Jin H Park,Jiwen Zheng et al.
Deyun Wang et al.
An oil-in-water (o/w) nanoemulsion (NE), composed of oil globules, stabilized by a surfactant, and dispersed in an aqueous phase, is increasingly developed in complex drug formulation. Kinetically stable NEs are used to formulate hydrophobi...