First-in-human PET imaging and evaluation of melanin-targeted [18F]DMPY2 in malignant melanoma patients [0.03%]
恶性黑色素瘤患者中针对黑色素的正电子发射断层扫描成像以及[18F]DMPY2的首次人体评估研究
Yi Yang,Ming Zhou,Shuang Zhao et al.
Yi Yang et al.
Aim: Early diagnosis and accurate malignant melanoma (MM) staging are significant and decisive in clinical practice. [18F]DMPY2 is a promising PET tracer in vivo with high affinity and selectivity for melanin. The study aims to investigate ...
Combined Melanin-Targeted Radionuclide Therapy and Immunotherapy in Pigmented Advanced Malignant Melanoma [0.03%]
黑色素靶向核素治疗联合免疫治疗在色素恶性黑色素瘤中的应用
Hongyan Feng,Zhengyuan Hong,Lihong Bu
Hongyan Feng
The benzamide analogue 131I-N-(2-(diethylamino)ethyl)-5-(iodo-131I) picolinamide (131I-5-IPN) was developed for targeted radionuclide therapy (TRNT) of pigmented melanoma and showed good pharmacokinetics and a high melanin-binding affinity....
Development of 99mTc-labeled melanin-targeted probes for SPECT imaging of melanoma [0.03%]
99mTc标记的黑色素 targeted探针的制备及其体内外评价
Ji Tao,Rui Cao,Zhe Lei et al.
Ji Tao et al.
Purpose: Melanoma is a highly aggressive skin cancer with poor prognosis, highlighting the need for early detection. This study aims to develop a 99mTc-labeled single photon emission computed tomography (SPECT) probe targ...
A Novel Melanin-Targeted 18F-PFPN Positron Emission Tomography Imaging for Diagnosing Ocular and Orbital Melanoma [0.03%]
一种新型黑色素靶向18F-PFPN正电子发射断层扫描成像技术在眼和眶部黑色素瘤诊断中的应用
Yiyan Wang,Xinghua Wang,Jie Zhang et al.
Yiyan Wang et al.
Objective: 18F-N-(2-(Diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy) picolinamide (18F-PFPN) is a novel positron emission tomography (PET) probe designed to specifically targets melanin. This study aimed to eva...
miR-181a/b-5p negatively regulates keratinocytes proliferation by targeting MELK [0.03%]
miR-181a/b-5p通过靶向MELK抑制角质形成细胞增殖
Mutian Niu,Mingzhao Li,Xiaomei Fan et al.
Mutian Niu et al.
Accumulating evidence indicates that microRNAs (miRNAs) have a vital effect on the pathogenesis of psoriasis. This study is conducted to investigate the potential involvement of miR-181a-5p and miR-181b-5p in the proliferation of HaCaT kera...
Melanin-Targeting Radiotracers and Their Preclinical, Translational, and Clinical Status: From Past to Future [0.03%]
黑色素靶向放射性示踪剂及其临床前、转化和临床现状：从过去到现在及未来展望
Xiao Zhang,Zhaoguo Lin,Yuan Feng et al.
Xiao Zhang et al.
Melanin is one of the representative biomarkers of malignant melanoma and a potential target for diagnosis and therapy. With advancements in chemistry and radiolabeling technologies, promising strides have been made to synthesize radiolabel...
Melanin-targeted [18F]-PFPN PET imaging may shed light for clear cell sarcoma [0.03%]
黑色素靶向[18F]-PFPN PET显像有望促进透明细胞肉瘤的诊疗
Xiao Zhang,Fei Kang,Huaiyuan Zheng et al.
Xiao Zhang et al.
Purpose: Intracytoplasmic melanin pigment is a characteristic of clear cell sarcoma (CCS), which is a particularly deadly type of soft-tissue sarcoma. [18F]-N-(2-(diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)...
A Theranostic Approach to Imaging and Treating Melanoma with 203Pb/212Pb-Labeled Antibody Targeting Melanin [0.03%]
一种新的肿瘤诊疗法：用标记抗体针对黑色素影像和治疗黑色素瘤
Rubin Jiao,Kevin J H Allen,Mackenzie E Malo et al.
Rubin Jiao et al.
Metastatic melanoma is a deadly disease that claims thousands of lives each year despite the introduction of several immunotherapeutic agents into the clinic over the past decade, inspiring the development of novel therapeutics and the expl...
Melanin-targeted [18F]-PFPN PET imaging for prognosticating patients with melanoma [0.03%]
黑色素靶向[18F]-PFPN-PET显像对恶性黑色素瘤患者的预后判断价值
Xiao Zhang,Zhaoguo Lin,Mengting Li et al.
Xiao Zhang et al.
Purpose: Positron emission tomography (PET) using [18F]-PFPN, a melanin-targeted imaging tracer, has excellent diagnostic performance in patients with melanoma. This study aimed to investigate its value in prognostication...
Kevin J H Allen,Mackenzie E Malo,Rubin Jiao et al.
Kevin J H Allen et al.
Nearly 100,000 individuals are expected to be diagnosed with melanoma in the United States in 2022. Treatment options for late-stage metastatic disease up until the 2010s were few and offered only slight improvement to the overall survival....
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